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- W4386573573 abstract "Double-stranded DNA-specific cytidine deaminase (DddA) base editors hold great promise for applications in bio-medical research, medicine, and biotechnology. Strict sequence preference on spacing region presents a challenge for DddA editors to reach their full potential. To overcome this sequence-context constraint, we analyzed a protein dataset and identified a novel DddAtox homolog from Ruminococcus sp. AF17-6 (RsDddA). We engineered RsDddA for mitochondrial base editing in a mammalian cell line and demonstrated RsDddA-derived cytosine base editors (RsDdCBE) offered a broadened NC sequence compatibility and exhibited robust editing efficiency. Moreover, our results suggest the average frequencies of mitochondrial genome-wide off-target editing arising from RsDdCBE are comparable to canonical DdCBE and its variants." @default.
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- W4386573573 date "2023-12-01" @default.
- W4386573573 modified "2023-10-16" @default.
- W4386573573 title "Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity" @default.
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- W4386573573 doi "https://doi.org/10.1016/j.omtn.2023.09.005" @default.
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