Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386573747> ?p ?o ?g. }
- W4386573747 abstract "Abstract Myocardin-related transcription factors (MRTFs) are coactivators of serum response factor (SRF), and thereby regulate cytoskeletal gene expression in response to actin dynamics. MRTFs have also been implicated in heat shock protein ( hsp ) transcription in fly ovaries, but the mechanisms remain unclear. Here we demonstrate that in mammalian cells, MRTFs are dispensable for hsp gene induction. However, the widely used small molecule inhibitors of MRTF/SRF transcription pathway, derived from CCG-1423, efficiently inhibit hsp gene transcription in both fly and mammalian cells also in absence of MRTFs. Quantifying RNA synthesis and RNA polymerase distribution demonstrates that CCG-1423-derived compounds have a genome-wide effect on transcription. Indeed, tracking nascent transcription at nucleotide resolution reveals that CCG-1423-derived compounds reduce RNA polymerase II elongation, and severely dampen the transcriptional response to heat shock. The effects of CCG-1423-derived compounds therefore extend beyond the MRTF/SRF pathway into nascent transcription, opening novel opportunities for their use in transcription research." @default.
- W4386573747 created "2023-09-10" @default.
- W4386573747 creator A5008736422 @default.
- W4386573747 creator A5011142044 @default.
- W4386573747 creator A5019823938 @default.
- W4386573747 creator A5034812233 @default.
- W4386573747 creator A5060662450 @default.
- W4386573747 creator A5080784387 @default.
- W4386573747 creator A5092833128 @default.
- W4386573747 date "2023-09-08" @default.
- W4386573747 modified "2023-09-30" @default.
- W4386573747 title "CCG-1423-derived compounds reduce global RNA synthesis and inhibit transcriptional responses" @default.
- W4386573747 cites W1967487834 @default.
- W4386573747 cites W1985567287 @default.
- W4386573747 cites W1987557442 @default.
- W4386573747 cites W1988605254 @default.
- W4386573747 cites W2000418155 @default.
- W4386573747 cites W2003171404 @default.
- W4386573747 cites W2014182371 @default.
- W4386573747 cites W2021341670 @default.
- W4386573747 cites W2025060557 @default.
- W4386573747 cites W2025082472 @default.
- W4386573747 cites W2036897871 @default.
- W4386573747 cites W2065589175 @default.
- W4386573747 cites W2078190293 @default.
- W4386573747 cites W2078531707 @default.
- W4386573747 cites W2084272633 @default.
- W4386573747 cites W2087654007 @default.
- W4386573747 cites W2093723806 @default.
- W4386573747 cites W2093827499 @default.
- W4386573747 cites W2098977806 @default.
- W4386573747 cites W2114051326 @default.
- W4386573747 cites W2122683221 @default.
- W4386573747 cites W2131200617 @default.
- W4386573747 cites W2143790852 @default.
- W4386573747 cites W2149258710 @default.
- W4386573747 cites W2149650698 @default.
- W4386573747 cites W2170551349 @default.
- W4386573747 cites W2172194140 @default.
- W4386573747 cites W2179438025 @default.
- W4386573747 cites W2298612765 @default.
- W4386573747 cites W2306540679 @default.
- W4386573747 cites W2341539131 @default.
- W4386573747 cites W2405058103 @default.
- W4386573747 cites W2461013690 @default.
- W4386573747 cites W2486890521 @default.
- W4386573747 cites W2498392978 @default.
- W4386573747 cites W2548177822 @default.
- W4386573747 cites W2552668470 @default.
- W4386573747 cites W2554375517 @default.
- W4386573747 cites W2599057690 @default.
- W4386573747 cites W2743018412 @default.
- W4386573747 cites W2755390119 @default.
- W4386573747 cites W2793022688 @default.
- W4386573747 cites W2805385468 @default.
- W4386573747 cites W2896399042 @default.
- W4386573747 cites W2945567049 @default.
- W4386573747 cites W2950111786 @default.
- W4386573747 cites W2967438276 @default.
- W4386573747 cites W3033636830 @default.
- W4386573747 cites W3127787514 @default.
- W4386573747 cites W3143533906 @default.
- W4386573747 cites W3179561651 @default.
- W4386573747 cites W3202461875 @default.
- W4386573747 cites W4220930055 @default.
- W4386573747 cites W4221026014 @default.
- W4386573747 cites W4224236136 @default.
- W4386573747 cites W4226051960 @default.
- W4386573747 cites W4248747409 @default.
- W4386573747 cites W4249138713 @default.
- W4386573747 cites W4280577669 @default.
- W4386573747 cites W4281690804 @default.
- W4386573747 cites W4292230946 @default.
- W4386573747 doi "https://doi.org/10.1101/2023.09.08.556810" @default.
- W4386573747 hasPublicationYear "2023" @default.
- W4386573747 type Work @default.
- W4386573747 citedByCount "0" @default.
- W4386573747 crossrefType "posted-content" @default.
- W4386573747 hasAuthorship W4386573747A5008736422 @default.
- W4386573747 hasAuthorship W4386573747A5011142044 @default.
- W4386573747 hasAuthorship W4386573747A5019823938 @default.
- W4386573747 hasAuthorship W4386573747A5034812233 @default.
- W4386573747 hasAuthorship W4386573747A5060662450 @default.
- W4386573747 hasAuthorship W4386573747A5080784387 @default.
- W4386573747 hasAuthorship W4386573747A5092833128 @default.
- W4386573747 hasBestOaLocation W43865737471 @default.
- W4386573747 hasConcept C101762097 @default.
- W4386573747 hasConcept C104317684 @default.
- W4386573747 hasConcept C138885662 @default.
- W4386573747 hasConcept C150194340 @default.
- W4386573747 hasConcept C153911025 @default.
- W4386573747 hasConcept C179926584 @default.
- W4386573747 hasConcept C185592680 @default.
- W4386573747 hasConcept C41895202 @default.
- W4386573747 hasConcept C55493867 @default.
- W4386573747 hasConcept C64350747 @default.
- W4386573747 hasConcept C67705224 @default.
- W4386573747 hasConcept C69053785 @default.
- W4386573747 hasConcept C86339819 @default.
- W4386573747 hasConcept C86803240 @default.