FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386574073> ?p ?o ?g. }

• W4386574073 endingPage "106579" @default.
• W4386574073 startingPage "106579" @default.
• W4386574073 abstract "Cancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The drug efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP), play the crucial roles in this sophisticated battle. In recent decades, researchers try to find potential inhibitors to impede the drug efflux function of above transporters. d-α-Tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS) is a prevalently used excipient in the formulation design. In the present study, the modulatory effects and mechanisms of vitamin E TPGS on the efflux transporters were investigated. And the cancer MDR reversing ability of vitamin E TPGS was evaluated as well. Stable-cloned transporter over-expressed cell lines were used for mechanisms study, while several types of MDR cancer cell lines were adopted as reversing evaluation models. The results exhibited that vitamin E TPGS significantly inhibited the efflux function of P-gp, MRP1, and BCRP under non-cytotoxic concentrations, but not influencing the protein expression levels. Through efflux assay and molecular docking, vitamin E TPGS was found to be an uncompetitive, non-competitive, and competitive inhibitor on chemotherapeutic drug doxorubicin efflux in P-gp, MRP1, and BCRP over-expressing cell lines, respectively. Furthermore, the basal ATPase activity of three transporters were significantly inhibited by vitamin E TPGS at 10 μM. And the cell membrane fluidity of P-gp over-expressing cell line was enhanced by 22.58% with 5 μM vitamin E TPGS treatment, compared to the parental Flp-In™-293 cell line (without P-gp). The resistance reversing ability of vitamin E TPGS was prominent in MCF-7/DOX MDR breast cancer cell line, which over-expressed P-gp, MRP1, and BCRP. These significant results suggested that vitamin E TPGS is a promising modulator on transporters mediated cancer MDR. Vitamin E TPGS is not an inert excipient, but possesses MDR-reversing pharmacological effects, and deserves a re-purposing application on the future combinatorial regimen design for MDR cancer treatment." @default.
• W4386574073 created "2023-09-10" @default.
• W4386574073 creator A5008130838 @default.
• W4386574073 creator A5013938471 @default.
• W4386574073 creator A5020966645 @default.
• W4386574073 creator A5021128888 @default.
• W4386574073 creator A5027296029 @default.
• W4386574073 creator A5028437162 @default.
• W4386574073 date "2023-11-01" @default.
• W4386574073 modified "2023-10-15" @default.
• W4386574073 title "Redefine the role of D-α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance" @default.
• W4386574073 cites W1498108228 @default.
• W4386574073 cites W1515796335 @default.
• W4386574073 cites W1973094544 @default.
• W4386574073 cites W1974652764 @default.
• W4386574073 cites W1987104113 @default.
• W4386574073 cites W1988687570 @default.
• W4386574073 cites W1989335851 @default.
• W4386574073 cites W1999435663 @default.
• W4386574073 cites W2034224323 @default.
• W4386574073 cites W2045128339 @default.
• W4386574073 cites W2060265857 @default.
• W4386574073 cites W2061215349 @default.
• W4386574073 cites W2082177807 @default.
• W4386574073 cites W2098142549 @default.
• W4386574073 cites W2112820588 @default.
• W4386574073 cites W2149994120 @default.
• W4386574073 cites W2157274368 @default.
• W4386574073 cites W2168139227 @default.
• W4386574073 cites W2204945050 @default.
• W4386574073 cites W2256592413 @default.
• W4386574073 cites W2559608386 @default.
• W4386574073 cites W2589923912 @default.
• W4386574073 cites W2619656708 @default.
• W4386574073 cites W2793096195 @default.
• W4386574073 cites W2796451806 @default.
• W4386574073 cites W2896626047 @default.
• W4386574073 cites W2913173637 @default.
• W4386574073 cites W2944725533 @default.
• W4386574073 cites W2946182267 @default.
• W4386574073 cites W2950977232 @default.
• W4386574073 cites W2990802341 @default.
• W4386574073 cites W3003960861 @default.
• W4386574073 cites W3011825793 @default.
• W4386574073 cites W3111214144 @default.
• W4386574073 cites W3116958628 @default.
• W4386574073 cites W3170839452 @default.
• W4386574073 cites W3215306027 @default.
• W4386574073 cites W4200051371 @default.
• W4386574073 cites W4221015171 @default.
• W4386574073 cites W4225123732 @default.
• W4386574073 cites W4225933690 @default.
• W4386574073 cites W4250709808 @default.
• W4386574073 cites W4307903167 @default.
• W4386574073 cites W4308743067 @default.
• W4386574073 cites W4316464333 @default.
• W4386574073 cites W4319216277 @default.
• W4386574073 cites W4321071963 @default.
• W4386574073 cites W4322616926 @default.
• W4386574073 cites W4367838969 @default.
• W4386574073 cites W66407225 @default.
• W4386574073 doi "https://doi.org/10.1016/j.ejps.2023.106579" @default.
• W4386574073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37689120" @default.
• W4386574073 hasPublicationYear "2023" @default.
• W4386574073 type Work @default.
• W4386574073 citedByCount "0" @default.
• W4386574073 crossrefType "journal-article" @default.
• W4386574073 hasAuthorship W4386574073A5008130838 @default.
• W4386574073 hasAuthorship W4386574073A5013938471 @default.
• W4386574073 hasAuthorship W4386574073A5020966645 @default.
• W4386574073 hasAuthorship W4386574073A5021128888 @default.
• W4386574073 hasAuthorship W4386574073A5027296029 @default.
• W4386574073 hasAuthorship W4386574073A5028437162 @default.
• W4386574073 hasBestOaLocation W43865740731 @default.
• W4386574073 hasConcept C104317684 @default.
• W4386574073 hasConcept C114851261 @default.
• W4386574073 hasConcept C121608353 @default.
• W4386574073 hasConcept C133936738 @default.
• W4386574073 hasConcept C149011108 @default.
• W4386574073 hasConcept C185592680 @default.
• W4386574073 hasConcept C200082930 @default.
• W4386574073 hasConcept C2776375370 @default.
• W4386574073 hasConcept C2778707650 @default.
• W4386574073 hasConcept C44312359 @default.
• W4386574073 hasConcept C512196 @default.
• W4386574073 hasConcept C54355233 @default.
• W4386574073 hasConcept C55493867 @default.
• W4386574073 hasConcept C86803240 @default.
• W4386574073 hasConcept C89423630 @default.
• W4386574073 hasConcept C96232424 @default.
• W4386574073 hasConcept C98274493 @default.
• W4386574073 hasConceptScore W4386574073C104317684 @default.
• W4386574073 hasConceptScore W4386574073C114851261 @default.
• W4386574073 hasConceptScore W4386574073C121608353 @default.
• W4386574073 hasConceptScore W4386574073C133936738 @default.
• W4386574073 hasConceptScore W4386574073C149011108 @default.
• W4386574073 hasConceptScore W4386574073C185592680 @default.
• W4386574073 hasConceptScore W4386574073C200082930 @default.

• next