Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386574494> ?p ?o ?g. }
- W4386574494 abstract "Abstract Sarpagine alkaloids offer signicant opportunities in drug discovery, yet the efficient total syntheses and diverse structural modifications of these natural products remain highly challenging due to the architectural complexity. Here we show a homo-Mannich reaction of cyclopropanol with imines generated via a Bischler-Napieralski reaction enables a protecting-group-free, redox economic, four-step access to the tetracyclic sarpagine core from L -tryptophan esters. Based on this advancement, diversified syntheses of sarpagine alkaloids and analogues are achieved in a short synthetic route. The systematic anticancer evaluation indicates that natural products vellosimine and N a -methyl vellosimine possess modest anticancer activity. Intensive structural optimization of these lead molecules and exploration of the structure−activity relationship lead to the identification of analogue 15ai with an allene unit showing a tenfold improvement in anticancer activities. Further mechanism studies indicate compound 15ai exertes antiproliferation effects by inducing ferroptosis, which is an appealing non-apoptotic cell death form that may provide new solutions in future cancer therapies." @default.
- W4386574494 created "2023-09-10" @default.
- W4386574494 creator A5017525793 @default.
- W4386574494 creator A5035368082 @default.
- W4386574494 creator A5046891661 @default.
- W4386574494 creator A5058333725 @default.
- W4386574494 creator A5058435392 @default.
- W4386574494 creator A5065864391 @default.
- W4386574494 creator A5069321096 @default.
- W4386574494 creator A5087890252 @default.
- W4386574494 date "2023-09-09" @default.
- W4386574494 modified "2023-09-28" @default.
- W4386574494 title "A Bischler-Napieralski and homo-Mannich sequence enables diversified syntheses of sarpagine alkaloids and analogues" @default.
- W4386574494 cites W1973741554 @default.
- W4386574494 cites W2004279451 @default.
- W4386574494 cites W2004343827 @default.
- W4386574494 cites W2018504556 @default.
- W4386574494 cites W2038048189 @default.
- W4386574494 cites W2060742794 @default.
- W4386574494 cites W2061326043 @default.
- W4386574494 cites W2072037631 @default.
- W4386574494 cites W2091222088 @default.
- W4386574494 cites W2102924538 @default.
- W4386574494 cites W2143012335 @default.
- W4386574494 cites W2153034135 @default.
- W4386574494 cites W2156485663 @default.
- W4386574494 cites W2156922387 @default.
- W4386574494 cites W2164049537 @default.
- W4386574494 cites W2164851208 @default.
- W4386574494 cites W2176378800 @default.
- W4386574494 cites W2318849814 @default.
- W4386574494 cites W2324404869 @default.
- W4386574494 cites W2324611410 @default.
- W4386574494 cites W2492849394 @default.
- W4386574494 cites W2526216986 @default.
- W4386574494 cites W2553207120 @default.
- W4386574494 cites W2791080979 @default.
- W4386574494 cites W2800527376 @default.
- W4386574494 cites W2900540320 @default.
- W4386574494 cites W2916432747 @default.
- W4386574494 cites W2918205503 @default.
- W4386574494 cites W2945478689 @default.
- W4386574494 cites W2952029787 @default.
- W4386574494 cites W2952057843 @default.
- W4386574494 cites W2952691817 @default.
- W4386574494 cites W3007737477 @default.
- W4386574494 cites W3045989894 @default.
- W4386574494 cites W3087582521 @default.
- W4386574494 cites W3089846392 @default.
- W4386574494 cites W3093912291 @default.
- W4386574494 cites W3150709095 @default.
- W4386574494 cites W3163145088 @default.
- W4386574494 cites W3168324724 @default.
- W4386574494 cites W3208325945 @default.
- W4386574494 cites W3214500018 @default.
- W4386574494 cites W4205504438 @default.
- W4386574494 cites W4210748568 @default.
- W4386574494 cites W4212765632 @default.
- W4386574494 cites W4221112683 @default.
- W4386574494 cites W4254866804 @default.
- W4386574494 cites W4280577060 @default.
- W4386574494 cites W4281285383 @default.
- W4386574494 doi "https://doi.org/10.1038/s41467-023-41268-9" @default.
- W4386574494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37689783" @default.
- W4386574494 hasPublicationYear "2023" @default.
- W4386574494 type Work @default.
- W4386574494 citedByCount "0" @default.
- W4386574494 crossrefType "journal-article" @default.
- W4386574494 hasAuthorship W4386574494A5017525793 @default.
- W4386574494 hasAuthorship W4386574494A5035368082 @default.
- W4386574494 hasAuthorship W4386574494A5046891661 @default.
- W4386574494 hasAuthorship W4386574494A5058333725 @default.
- W4386574494 hasAuthorship W4386574494A5058435392 @default.
- W4386574494 hasAuthorship W4386574494A5065864391 @default.
- W4386574494 hasAuthorship W4386574494A5069321096 @default.
- W4386574494 hasAuthorship W4386574494A5087890252 @default.
- W4386574494 hasBestOaLocation W43865744941 @default.
- W4386574494 hasConcept C161790260 @default.
- W4386574494 hasConcept C185592680 @default.
- W4386574494 hasConcept C21951064 @default.
- W4386574494 hasConcept C2778652500 @default.
- W4386574494 hasConcept C2780640045 @default.
- W4386574494 hasConcept C55493867 @default.
- W4386574494 hasConcept C70721500 @default.
- W4386574494 hasConcept C71240020 @default.
- W4386574494 hasConcept C74187038 @default.
- W4386574494 hasConcept C86803240 @default.
- W4386574494 hasConceptScore W4386574494C161790260 @default.
- W4386574494 hasConceptScore W4386574494C185592680 @default.
- W4386574494 hasConceptScore W4386574494C21951064 @default.
- W4386574494 hasConceptScore W4386574494C2778652500 @default.
- W4386574494 hasConceptScore W4386574494C2780640045 @default.
- W4386574494 hasConceptScore W4386574494C55493867 @default.
- W4386574494 hasConceptScore W4386574494C70721500 @default.
- W4386574494 hasConceptScore W4386574494C71240020 @default.
- W4386574494 hasConceptScore W4386574494C74187038 @default.
- W4386574494 hasConceptScore W4386574494C86803240 @default.
- W4386574494 hasIssue "1" @default.
- W4386574494 hasLocation W43865744941 @default.
- W4386574494 hasLocation W43865744942 @default.