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- W4386575360 endingPage "115799" @default.
- W4386575360 startingPage "115799" @default.
- W4386575360 abstract "Histone demethylation is a kind of epigenetic modification mediated by a variety of enzymes and participates in regulating multiple physiological and pathological events. Lysine-specific demethylase 7A is a kind of α-ketoglutarate- and Fe(II)-dependent demethylase belonging to the PHF2/8 subfamily of the JmjC demethylases. KDM7A is mainly localized in the nucleus and contributes to transcriptional activation via removing mono- and di-methyl groups from the lysine residues 9 and 27 of Histone H3. Mounting studies support that KDM7A is not only necessary for normal embryonic, neural, and skeletal development, but also associated with cancer, inflammation, osteoporosis, and other diseases. Herein, the structure of KDM7A is described by comparing the similarities and differences of its amino acid sequences of KDM7A and other Histone demethylases; the functions of KDM7A in homeostasis and dyshomeostasis are summarized via documenting its content and related signaling; the currently known KDM7A-specific inhibitors and their structural relationship are listed based on their structure optimization and pharmacological activities; and the challenges and opportunities in exploring functions and developing targeted agents of KDM7A are also prospected via presenting encountered problems and potential solutions, which will provide an insight in functional exploration and drug discovery for KDM7A-related diseases." @default.
- W4386575360 created "2023-09-10" @default.
- W4386575360 creator A5029688473 @default.
- W4386575360 creator A5030441807 @default.
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- W4386575360 creator A5088665887 @default.
- W4386575360 creator A5089901727 @default.
- W4386575360 date "2023-10-01" @default.
- W4386575360 modified "2023-10-17" @default.
- W4386575360 title "Lysine-specific demethylase 7A (KDM7A): A potential target for disease therapy" @default.
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