Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386586118> ?p ?o ?g. }
- W4386586118 endingPage "110897" @default.
- W4386586118 startingPage "110897" @default.
- W4386586118 abstract "Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver disorders and accompanied by multiple metabolic dysfunctions. Although excessive lipid accumulation in hepatocytes has been identified as a crucial mediator of NAFLD development, the underlying mechanisms are very complicated and remain largely unknown. In this study, we reported that upregulated expression of the seven in absentia homolog 1 (Siah1) in the liver exacerbated NAFLD progression. Conversely, Siah1 downregulation markedly alleviated the high fat diet-induced accumulation of hepatic fat and expression of genes related to lipid metabolism in vitro and in vivo. The mechanistic study revealed that Siah1 interacted with sterol carrier protein 2 (Scp2) and promotes its ubiquitination and degradation, suggesting that Siah1 is an important activator of Scp2 ubiquitination in the context of NAFLD. Our results demonstrated that Siah1 regulated the lipid accumulation in NAFLD by interacting with Scp2. Thus, this study presents Siah1 as a promising therapeutic target in the development of NAFLD." @default.
- W4386586118 created "2023-09-11" @default.
- W4386586118 creator A5002119595 @default.
- W4386586118 creator A5011073256 @default.
- W4386586118 creator A5024424242 @default.
- W4386586118 creator A5028075867 @default.
- W4386586118 creator A5030943918 @default.
- W4386586118 creator A5034868438 @default.
- W4386586118 creator A5037270097 @default.
- W4386586118 creator A5041249812 @default.
- W4386586118 creator A5042282225 @default.
- W4386586118 creator A5089081998 @default.
- W4386586118 creator A5089346348 @default.
- W4386586118 date "2023-11-01" @default.
- W4386586118 modified "2023-10-18" @default.
- W4386586118 title "E3 ubiquitin ligase Siah1 aggravates NAFLD through Scp2 ubiquitination" @default.
- W4386586118 cites W1975742878 @default.
- W4386586118 cites W2060205727 @default.
- W4386586118 cites W2069364461 @default.
- W4386586118 cites W2118231738 @default.
- W4386586118 cites W2140672690 @default.
- W4386586118 cites W2204688218 @default.
- W4386586118 cites W2582107239 @default.
- W4386586118 cites W2593873315 @default.
- W4386586118 cites W2745765928 @default.
- W4386586118 cites W2756601401 @default.
- W4386586118 cites W2782042415 @default.
- W4386586118 cites W2793230148 @default.
- W4386586118 cites W2941033601 @default.
- W4386586118 cites W3012883032 @default.
- W4386586118 cites W3027610925 @default.
- W4386586118 cites W3082613976 @default.
- W4386586118 cites W3102906690 @default.
- W4386586118 cites W3131606909 @default.
- W4386586118 cites W3154213543 @default.
- W4386586118 cites W3154897461 @default.
- W4386586118 cites W3170394737 @default.
- W4386586118 cites W3179827971 @default.
- W4386586118 cites W3180573026 @default.
- W4386586118 cites W3201074151 @default.
- W4386586118 cites W3203386040 @default.
- W4386586118 cites W4220666621 @default.
- W4386586118 cites W4221028476 @default.
- W4386586118 doi "https://doi.org/10.1016/j.intimp.2023.110897" @default.
- W4386586118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37696143" @default.
- W4386586118 hasPublicationYear "2023" @default.
- W4386586118 type Work @default.
- W4386586118 citedByCount "0" @default.
- W4386586118 crossrefType "journal-article" @default.
- W4386586118 hasAuthorship W4386586118A5002119595 @default.
- W4386586118 hasAuthorship W4386586118A5011073256 @default.
- W4386586118 hasAuthorship W4386586118A5024424242 @default.
- W4386586118 hasAuthorship W4386586118A5028075867 @default.
- W4386586118 hasAuthorship W4386586118A5030943918 @default.
- W4386586118 hasAuthorship W4386586118A5034868438 @default.
- W4386586118 hasAuthorship W4386586118A5037270097 @default.
- W4386586118 hasAuthorship W4386586118A5041249812 @default.
- W4386586118 hasAuthorship W4386586118A5042282225 @default.
- W4386586118 hasAuthorship W4386586118A5089081998 @default.
- W4386586118 hasAuthorship W4386586118A5089346348 @default.
- W4386586118 hasConcept C104317684 @default.
- W4386586118 hasConcept C126322002 @default.
- W4386586118 hasConcept C127561419 @default.
- W4386586118 hasConcept C134018914 @default.
- W4386586118 hasConcept C134459356 @default.
- W4386586118 hasConcept C25602115 @default.
- W4386586118 hasConcept C2776954865 @default.
- W4386586118 hasConcept C2778772119 @default.
- W4386586118 hasConcept C2779134260 @default.
- W4386586118 hasConcept C4733338 @default.
- W4386586118 hasConcept C55493867 @default.
- W4386586118 hasConcept C71924100 @default.
- W4386586118 hasConcept C86803240 @default.
- W4386586118 hasConceptScore W4386586118C104317684 @default.
- W4386586118 hasConceptScore W4386586118C126322002 @default.
- W4386586118 hasConceptScore W4386586118C127561419 @default.
- W4386586118 hasConceptScore W4386586118C134018914 @default.
- W4386586118 hasConceptScore W4386586118C134459356 @default.
- W4386586118 hasConceptScore W4386586118C25602115 @default.
- W4386586118 hasConceptScore W4386586118C2776954865 @default.
- W4386586118 hasConceptScore W4386586118C2778772119 @default.
- W4386586118 hasConceptScore W4386586118C2779134260 @default.
- W4386586118 hasConceptScore W4386586118C4733338 @default.
- W4386586118 hasConceptScore W4386586118C55493867 @default.
- W4386586118 hasConceptScore W4386586118C71924100 @default.
- W4386586118 hasConceptScore W4386586118C86803240 @default.
- W4386586118 hasLocation W43865861181 @default.
- W4386586118 hasLocation W43865861182 @default.
- W4386586118 hasOpenAccess W4386586118 @default.
- W4386586118 hasPrimaryLocation W43865861181 @default.
- W4386586118 hasRelatedWork W2007249806 @default.
- W4386586118 hasRelatedWork W2017565084 @default.
- W4386586118 hasRelatedWork W2043590168 @default.
- W4386586118 hasRelatedWork W2094494461 @default.
- W4386586118 hasRelatedWork W2102368462 @default.
- W4386586118 hasRelatedWork W2112492009 @default.
- W4386586118 hasRelatedWork W3110810129 @default.
- W4386586118 hasRelatedWork W3156524163 @default.