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- W4386586152 endingPage "115458" @default.
- W4386586152 startingPage "115458" @default.
- W4386586152 abstract "The Stimulator of Interferon Genes (STING) is predominantly expressed in immune cells, including macrophages, natural killer cells, dendritic cells, and T cells, functioning as a pattern recognition receptor. STING activation upon detecting cytosolic DNA released from damaged cells initiates downstream pathways, leading to the production of inflammatory cytokines such as IFNs, IL-6, and TNF-α. Dysregulated STING activation has been implicated in inflammatory and metabolic diseases. Ischemia/reperfusion injury (I/RI) is common in stroke, acute myocardial infarction, organ transplantation, and surgeries for certain end-stage diseases. Recent studies suggest that STING could be a novel therapeutic target for I/RI treatment. In this review, we provide a concise overview of the cGAS-STING signaling pathway's general functions and summarize STING's role in I/RI across various organs, including the heart, liver, kidney, and lung. Moreover, we explore potential therapeutic approaches for I/RI by targeting STING." @default.
- W4386586152 created "2023-09-11" @default.
- W4386586152 creator A5014616952 @default.
- W4386586152 creator A5016406653 @default.
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- W4386586152 creator A5075336895 @default.
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- W4386586152 creator A5087610827 @default.
- W4386586152 date "2023-11-01" @default.
- W4386586152 modified "2023-10-18" @default.
- W4386586152 title "Stimulator of interferon genes (STING): Key therapeutic targets in ischemia/reperfusion injury" @default.
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