Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386590314> ?p ?o ?g. }
- W4386590314 abstract "Herein, we have developed a drug-loaded matrix metalloproteinase (MMP)-responsive micellar nanoparticle (NP) intended for minimally invasive intravenous injection during the acute phase of myocardial infarction (MI) and prolonged retention in the heart for small-molecule drug delivery. Peptide-polymer amphiphiles (PPAs) bearing a small-molecule MMP inhibitor (MMPi), PD166793, were synthesized via ring-opening metathesis polymerization (ROMP) and formulated into spherical micelles by transitioning to aqueous solution. The resulting micellar NPs underwent MMP-induced aggregation, demonstrating enzyme responsiveness. Using a rat MI model, we observed that these NPs were capable of successfully extravasating into the infarcted region of the heart where they were retained due to the active, enzyme-mediated targeting, remaining detectable after 1 week post administration without increasing macrophage recruitment. Furthermore, in vitro studies show that these NPs demonstrated successful drug release following MMP treatment and maintained drug bioactivity as evidenced by comparable MMP inhibition to free MMPi. This work establishes a targeted NP platform for delivering small-molecule therapeutics to the heart after MI, opening possibilities for myocardial infarction treatment." @default.
- W4386590314 created "2023-09-11" @default.
- W4386590314 creator A5002186656 @default.
- W4386590314 creator A5012058861 @default.
- W4386590314 creator A5015322580 @default.
- W4386590314 creator A5076257090 @default.
- W4386590314 creator A5077694463 @default.
- W4386590314 creator A5084206681 @default.
- W4386590314 date "2023-09-11" @default.
- W4386590314 modified "2023-10-17" @default.
- W4386590314 title "Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to Acute Myocardial Infarction" @default.
- W4386590314 cites W111180501 @default.
- W4386590314 cites W1480124154 @default.
- W4386590314 cites W16158435 @default.
- W4386590314 cites W1968099944 @default.
- W4386590314 cites W1977111128 @default.
- W4386590314 cites W1977660216 @default.
- W4386590314 cites W1982808845 @default.
- W4386590314 cites W1986463666 @default.
- W4386590314 cites W2002898375 @default.
- W4386590314 cites W2036876430 @default.
- W4386590314 cites W2052650371 @default.
- W4386590314 cites W2067437696 @default.
- W4386590314 cites W2070580079 @default.
- W4386590314 cites W2076393481 @default.
- W4386590314 cites W2089557457 @default.
- W4386590314 cites W2093552166 @default.
- W4386590314 cites W2097105593 @default.
- W4386590314 cites W2110634891 @default.
- W4386590314 cites W2113339066 @default.
- W4386590314 cites W2117272739 @default.
- W4386590314 cites W2119024270 @default.
- W4386590314 cites W2141228550 @default.
- W4386590314 cites W2148075660 @default.
- W4386590314 cites W2150560481 @default.
- W4386590314 cites W2152040897 @default.
- W4386590314 cites W2157571064 @default.
- W4386590314 cites W2161866878 @default.
- W4386590314 cites W2172114461 @default.
- W4386590314 cites W2320613810 @default.
- W4386590314 cites W2596947530 @default.
- W4386590314 cites W2737907188 @default.
- W4386590314 cites W2776694463 @default.
- W4386590314 cites W2859532917 @default.
- W4386590314 cites W2913705661 @default.
- W4386590314 cites W2928131335 @default.
- W4386590314 cites W2935357358 @default.
- W4386590314 cites W2982624278 @default.
- W4386590314 cites W2995663437 @default.
- W4386590314 cites W3001060215 @default.
- W4386590314 cites W3110742188 @default.
- W4386590314 cites W3170322213 @default.
- W4386590314 doi "https://doi.org/10.1021/acs.biomac.3c00421" @default.
- W4386590314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37695847" @default.
- W4386590314 hasPublicationYear "2023" @default.
- W4386590314 type Work @default.
- W4386590314 citedByCount "0" @default.
- W4386590314 crossrefType "journal-article" @default.
- W4386590314 hasAuthorship W4386590314A5002186656 @default.
- W4386590314 hasAuthorship W4386590314A5012058861 @default.
- W4386590314 hasAuthorship W4386590314A5015322580 @default.
- W4386590314 hasAuthorship W4386590314A5076257090 @default.
- W4386590314 hasAuthorship W4386590314A5077694463 @default.
- W4386590314 hasAuthorship W4386590314A5084206681 @default.
- W4386590314 hasBestOaLocation W43865903141 @default.
- W4386590314 hasConcept C109523444 @default.
- W4386590314 hasConcept C11268172 @default.
- W4386590314 hasConcept C12554922 @default.
- W4386590314 hasConcept C126511603 @default.
- W4386590314 hasConcept C164705383 @default.
- W4386590314 hasConcept C178790620 @default.
- W4386590314 hasConcept C184651966 @default.
- W4386590314 hasConcept C185592680 @default.
- W4386590314 hasConcept C202751555 @default.
- W4386590314 hasConcept C2779820397 @default.
- W4386590314 hasConcept C2780035454 @default.
- W4386590314 hasConcept C500558357 @default.
- W4386590314 hasConcept C55493867 @default.
- W4386590314 hasConcept C71924100 @default.
- W4386590314 hasConcept C86803240 @default.
- W4386590314 hasConcept C98274493 @default.
- W4386590314 hasConceptScore W4386590314C109523444 @default.
- W4386590314 hasConceptScore W4386590314C11268172 @default.
- W4386590314 hasConceptScore W4386590314C12554922 @default.
- W4386590314 hasConceptScore W4386590314C126511603 @default.
- W4386590314 hasConceptScore W4386590314C164705383 @default.
- W4386590314 hasConceptScore W4386590314C178790620 @default.
- W4386590314 hasConceptScore W4386590314C184651966 @default.
- W4386590314 hasConceptScore W4386590314C185592680 @default.
- W4386590314 hasConceptScore W4386590314C202751555 @default.
- W4386590314 hasConceptScore W4386590314C2779820397 @default.
- W4386590314 hasConceptScore W4386590314C2780035454 @default.
- W4386590314 hasConceptScore W4386590314C500558357 @default.
- W4386590314 hasConceptScore W4386590314C55493867 @default.
- W4386590314 hasConceptScore W4386590314C71924100 @default.
- W4386590314 hasConceptScore W4386590314C86803240 @default.
- W4386590314 hasConceptScore W4386590314C98274493 @default.
- W4386590314 hasFunder F4320337338 @default.
- W4386590314 hasLocation W43865903141 @default.
- W4386590314 hasLocation W43865903142 @default.