FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386592086> ?p ?o ?g. }

• W4386592086 abstract "Abstract STUDY QUESTION What are the effects of male anxiety and depression on IVF outcomes? SUMMARY ANSWER Men with anxiety had lower final total motile sperm counts (fTMSC) during IVF compared to men without anxiety; however, there were no differences in live birth rates (LBRs). WHAT IS KNOWN ALREADY Studies have shown that male anxiety causes low sperm motility, worse sperm morphology, and increased DNA fragmentation, which are known to be influential factors on fertilization rates and embryo quality during IVF. However, data are lacking on whether there is a direct association between male anxiety and/or depression and IVF outcomes. STUDY DESIGN, SIZE, DURATION This was a survey-based, retrospective cohort study completed at a single, large hospital-affiliated fertility center with 222 respondents who underwent IVF with or without ICSI. The study was conducted between 6 September 2018 and 27 December 2022. PARTICIPANTS/MATERIALS, SETTING, METHODS Male partners of couples who underwent IVF or IVF/ICSI completed a Hospital Anxiety and Depression Scale (HADS) questionnaire. They were separated into two groups for both anxiety (HADS-A ≥ 8 or HADS-A &lt; 8) and depression (HADS-D ≥ 8 or HADS-D &lt; 8). Men with an elevated HADS-A or HADS-D score ≥8 were considered to have anxiety or depression, respectively. The primary outcome was LBR. Secondary outcomes included semen parameters at the time of IVF, cycle outcomes, pregnancy outcomes, and prevalence of erectile dysfunction and low libido. MAIN RESULTS AND THE ROLE OF CHANCE There were a total of 222 respondents, of whom 22.5% had a HADS-A ≥ 8 and 6.5% had a HADS-D ≥ 8. The average age of respondents was 37.38 ± 4.90 years old. Antidepressant use was higher in the respondents with a HADS-A or HADS-D ≥ 8 (P &lt; 0.05). Smoking use was similar between groups for both HADS-A and HADS-D (P &gt; 0.05). When adjusted for male BMI, antidepressant use and smoking, men with a HADS-A or HADS-D ≥ 8 had similar rates of erectile dysfunction (adjusted relative risk (aRR) = 1.12 (95% CI 0.60, 2.06)) and low libido (aRR = 1.70 (95% CI 0.91, 3.15)) compared to those with a HADS-A or HADS-D ≤ 8. Men with a HADS-A ≥ 8 were more likely to have a lower fTMSC on the day of oocyte retrieval (11.8 ≥ 8 vs 20.1 &lt; 8, adjusted ß = −0.66 (95% CI −1.22, −0.10)). However, the LBR per embryo transfer (ET) was similar between the HADS-A groups (43.2% ≥8 vs 45.1% &lt;8, adjusted relative risk = 0.90 (95% CI 0.65, 1.06)). Although depression was uncommon in the entire cohort, the HADS-D groups were clinically similar for fTMSC (18.7 ≥ 8 vs 16.0 &lt; 8) and LBR per ET (46.7% ≥8 vs 45.4% &lt;8). LIMITATIONS, REASONS FOR CAUTION Limitations of our study are the survey-based design, the lack of sperm morphology assessment at the time of IVF, our inability to fully assess the HADS-D ≥ 8 cohort due to the small sample size and the large Caucasian demographic. WIDER IMPLICATIONS OF THE FINDINGS Couples undergoing IVF have an increased likelihood of suffering from anxiety and/or depression. There is currently a debate on whether or not men should be treated with antidepressants while attempting to conceive due to potential detrimental effects on sperm quality. Our study shows that, regardless of antidepressant use, couples with men who did or did not report anxiety and/or depression have similar LBRs when undergoing IVF. Therefore, it is important to assess both partners for mental health and to not withhold treatment due to a concern about a potential impact of antidepressants or anxiety/depression on sperm quality. STUDY FUNDING/COMPETING INTEREST(S) There was no funding to report for this study. Z.W. is a contributing author for UptoDate. S.S.S. is on the advisory board for Ferring Pharmaceuticals. E.G. was a medical consultant for Hall-Matson Esq, Teladoc, and CRICO and is a contributing author for UptoDate. The remaining authors have nothing to report. TRIAL REGISTRATION NUMBER N/A." @default.
• W4386592086 created "2023-09-12" @default.
• W4386592086 creator A5003652664 @default.
• W4386592086 creator A5006596267 @default.
• W4386592086 creator A5029080245 @default.
• W4386592086 creator A5043492719 @default.
• W4386592086 creator A5057166056 @default.
• W4386592086 creator A5072243585 @default.
• W4386592086 date "2023-09-10" @default.
• W4386592086 modified "2023-09-29" @default.
• W4386592086 title "The effects of male anxiety and depression on IVF outcomes" @default.
• W4386592086 cites W124868395 @default.
• W4386592086 cites W1537561049 @default.
• W4386592086 cites W1968960587 @default.
• W4386592086 cites W1987138256 @default.
• W4386592086 cites W1994097253 @default.
• W4386592086 cites W2011152391 @default.
• W4386592086 cites W2018210037 @default.
• W4386592086 cites W2031824320 @default.
• W4386592086 cites W2051400639 @default.
• W4386592086 cites W2063592803 @default.
• W4386592086 cites W2089648137 @default.
• W4386592086 cites W2100217710 @default.
• W4386592086 cites W2118564819 @default.
• W4386592086 cites W2124182468 @default.
• W4386592086 cites W2132448690 @default.
• W4386592086 cites W2149366343 @default.
• W4386592086 cites W2157556026 @default.
• W4386592086 cites W2160331538 @default.
• W4386592086 cites W2236795621 @default.
• W4386592086 cites W2295931084 @default.
• W4386592086 cites W2534051607 @default.
• W4386592086 cites W2550134727 @default.
• W4386592086 cites W2566843902 @default.
• W4386592086 cites W2586833560 @default.
• W4386592086 cites W2587823503 @default.
• W4386592086 cites W2593888814 @default.
• W4386592086 cites W2601095682 @default.
• W4386592086 cites W2778932546 @default.
• W4386592086 cites W2804566355 @default.
• W4386592086 cites W2888225036 @default.
• W4386592086 cites W2891869793 @default.
• W4386592086 cites W2913371964 @default.
• W4386592086 cites W2973140050 @default.
• W4386592086 cites W2973982519 @default.
• W4386592086 cites W2978634365 @default.
• W4386592086 cites W3010344346 @default.
• W4386592086 cites W3040171918 @default.
• W4386592086 cites W3111127730 @default.
• W4386592086 cites W3113347365 @default.
• W4386592086 cites W3125932895 @default.
• W4386592086 cites W3130626218 @default.
• W4386592086 cites W3192373898 @default.
• W4386592086 cites W3206186810 @default.
• W4386592086 cites W4225264645 @default.
• W4386592086 cites W843338726 @default.
• W4386592086 doi "https://doi.org/10.1093/humrep/dead179" @default.
• W4386592086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37690112" @default.
• W4386592086 hasPublicationYear "2023" @default.
• W4386592086 type Work @default.
• W4386592086 citedByCount "0" @default.
• W4386592086 crossrefType "journal-article" @default.
• W4386592086 hasAuthorship W4386592086A5003652664 @default.
• W4386592086 hasAuthorship W4386592086A5006596267 @default.
• W4386592086 hasAuthorship W4386592086A5029080245 @default.
• W4386592086 hasAuthorship W4386592086A5043492719 @default.
• W4386592086 hasAuthorship W4386592086A5057166056 @default.
• W4386592086 hasAuthorship W4386592086A5072243585 @default.
• W4386592086 hasConcept C118552586 @default.
• W4386592086 hasConcept C126322002 @default.
• W4386592086 hasConcept C131872663 @default.
• W4386592086 hasConcept C139719470 @default.
• W4386592086 hasConcept C15744967 @default.
• W4386592086 hasConcept C162324750 @default.
• W4386592086 hasConcept C201903717 @default.
• W4386592086 hasConcept C2776867660 @default.
• W4386592086 hasConcept C2778279030 @default.
• W4386592086 hasConcept C2778739829 @default.
• W4386592086 hasConcept C2779234561 @default.
• W4386592086 hasConcept C2779366285 @default.
• W4386592086 hasConcept C2908647359 @default.
• W4386592086 hasConcept C29456083 @default.
• W4386592086 hasConcept C518429986 @default.
• W4386592086 hasConcept C54355233 @default.
• W4386592086 hasConcept C558461103 @default.
• W4386592086 hasConcept C71924100 @default.
• W4386592086 hasConcept C86803240 @default.
• W4386592086 hasConcept C99454951 @default.
• W4386592086 hasConceptScore W4386592086C118552586 @default.
• W4386592086 hasConceptScore W4386592086C126322002 @default.
• W4386592086 hasConceptScore W4386592086C131872663 @default.
• W4386592086 hasConceptScore W4386592086C139719470 @default.
• W4386592086 hasConceptScore W4386592086C15744967 @default.
• W4386592086 hasConceptScore W4386592086C162324750 @default.
• W4386592086 hasConceptScore W4386592086C201903717 @default.
• W4386592086 hasConceptScore W4386592086C2776867660 @default.
• W4386592086 hasConceptScore W4386592086C2778279030 @default.
• W4386592086 hasConceptScore W4386592086C2778739829 @default.
• W4386592086 hasConceptScore W4386592086C2779234561 @default.
• W4386592086 hasConceptScore W4386592086C2779366285 @default.

• next