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- W4386592250 abstract "Proteins with highly hydrophobic regions or aggregation-prone sequences are typically difficult targets for chemical synthesis at the current stage, as obtaining such type of peptides via solid-phase peptide synthesis requires sophisticated operations. Herein, we report N,O-benzylidene acetal dipeptides (NBDs) as robust and effective building blocks to allow the direct synthesis of difficult peptides and proteins via a kinked backbone strategy. The effectiveness and easy accessibility of NBDs have been well demonstrated in our chemical syntheses of various challenging peptides and proteins, including chemokine, therapeutic hormones, histone, and glycosylated erythropoietin." @default.
- W4386592250 created "2023-09-12" @default.
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- W4386592250 date "2023-09-20" @default.
- W4386592250 modified "2023-10-16" @default.
- W4386592250 title "N,O‐Benzylidene Acetal Dipeptides (NBDs) Enable the Synthesis of Difficult Peptides via a Kinked Backbone Strategy" @default.
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- W4386592250 doi "https://doi.org/10.1002/anie.202310624" @default.
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