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- W4386592806 abstract "Abstract: The pervasiveness and mortality associated with methamphetamine abuse has doubled during the past decade suggesting a possible worldwide substance use crisis. Epitomizing the pathophysiology and toxicology of methamphetamine abuse proclaims severe signs and symptoms of neurotoxic and neurobehavioral manifestations in both humans and animals. Most importantly, chronic use of this drug enhances the probability of developing neurodegenerative diseases manifolds. Parkinson’s disease is one such neurological disorder, which significantly and evidently not only shares a number of toxic pathogenic mechanisms induced by methamphetamine exposure but is also interlinked both structurally andgenetically. Methamphetamine-induced neurodegeneration involves altered dopamine homeostasis that promotes the aggregation of α-synuclein protofibrils in the dopaminergic neurons and drives these neurons to make them more vulnerable to degeneration as recognized in Parkinson’s disease. Moreover, the pathologic mechanisms such as mitochondrial dysfunction, oxidative stress, neuroinflammation and decreased neurogenesis detected in methamphetamine abusers dramatically resemble to what is observed in Parkinson’s disease cases. Therefore, the present review comprehensively cumulates a holistic illustration of various genetic and molecular mechanisms putting across the notion of how methamphetamine administration and intoxication might lead to Parkinson’s disease-like pathology and Parkinsonism." @default.
- W4386592806 created "2023-09-12" @default.
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- W4386592806 date "2023-09-07" @default.
- W4386592806 modified "2023-09-30" @default.
- W4386592806 title "The common denominators of Parkinson’s disease pathogenesis and methamphetamine abuse" @default.
- W4386592806 doi "https://doi.org/10.2174/1570159x21666230907151226" @default.
- W4386592806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37691228" @default.
- W4386592806 hasPublicationYear "2023" @default.
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