Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386593002> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4386593002 endingPage "791" @default.
- W4386593002 startingPage "786" @default.
- W4386593002 abstract "Zika virus' neural tropism causes significant neural pathology, particularly in developing fetuses. One of the consistent findings from humans and animal models is that prenatal exposure to Zika virus (ZIKV) causes pathology in the eyes and visual pathways of the brain, although the extent to which this pathology persists over development is not clear. In the present report, we build upon our previous work which demonstrated that full-term rhesus monkey ( Macaca mulatta ) fetuses who were exposed to ZIKV early in gestation had significant pathological abnormalities to the organization of the lateral geniculate nucleus (LGN), a major hub of the visual network. The objective of the present work was to replicate those LGN findings and determine whether such pathology persisted across childhood development. We carried out histological analyses of the LGNs of two juvenile rhesus monkeys who were prenatally exposed to ZIKV and two age-matched controls. Pregnant rhesus monkeys were infected with ZIKV via the intravenous and intra-amniotic routes and tracked across development. Following sacrifice and perfusion, brains were subjected to quantitative neuroanatomical analyses with a focus on the size and structure of the LGN and its composite layers. Early fetal ZIKV exposure resulted in developmental abnormalities within the brains' visual pathway: specifically disorganization, blending of layers, laminar discontinuities, and regions of low cell density within the LGN. These abnormalities were not observed in the control animals. Our findings demonstrate that the ZIKV's damage to the LGN that occurs during fetal development persists into childhood." @default.
- W4386593002 created "2023-09-12" @default.
- W4386593002 creator A5003765957 @default.
- W4386593002 creator A5041678225 @default.
- W4386593002 creator A5051281006 @default.
- W4386593002 creator A5053247451 @default.
- W4386593002 creator A5084723811 @default.
- W4386593002 creator A5087974711 @default.
- W4386593002 date "2023-09-11" @default.
- W4386593002 modified "2023-10-09" @default.
- W4386593002 title "Prenatal Zika virus exposure is associated with lateral geniculate nucleus abnormalities in juvenile rhesus macaques" @default.
- W4386593002 cites W1968165122 @default.
- W4386593002 cites W2024510213 @default.
- W4386593002 cites W2261656626 @default.
- W4386593002 cites W2292422784 @default.
- W4386593002 cites W2311276862 @default.
- W4386593002 cites W2337135418 @default.
- W4386593002 cites W2346484133 @default.
- W4386593002 cites W2356757232 @default.
- W4386593002 cites W2360131028 @default.
- W4386593002 cites W2372368841 @default.
- W4386593002 cites W2395528679 @default.
- W4386593002 cites W2519646798 @default.
- W4386593002 cites W2552937852 @default.
- W4386593002 cites W2582685715 @default.
- W4386593002 cites W2786279130 @default.
- W4386593002 cites W2792457101 @default.
- W4386593002 cites W2795111319 @default.
- W4386593002 cites W2806144513 @default.
- W4386593002 cites W2807967552 @default.
- W4386593002 cites W2957165718 @default.
- W4386593002 cites W2961245124 @default.
- W4386593002 cites W2961388244 @default.
- W4386593002 cites W2995845322 @default.
- W4386593002 cites W3008622993 @default.
- W4386593002 cites W3104878323 @default.
- W4386593002 cites W4221074907 @default.
- W4386593002 cites W4285494343 @default.
- W4386593002 doi "https://doi.org/10.1097/wnr.0000000000001953" @default.
- W4386593002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37695589" @default.
- W4386593002 hasPublicationYear "2023" @default.
- W4386593002 type Work @default.
- W4386593002 citedByCount "0" @default.
- W4386593002 crossrefType "journal-article" @default.
- W4386593002 hasAuthorship W4386593002A5003765957 @default.
- W4386593002 hasAuthorship W4386593002A5041678225 @default.
- W4386593002 hasAuthorship W4386593002A5051281006 @default.
- W4386593002 hasAuthorship W4386593002A5053247451 @default.
- W4386593002 hasAuthorship W4386593002A5084723811 @default.
- W4386593002 hasAuthorship W4386593002A5087974711 @default.
- W4386593002 hasConcept C105702510 @default.
- W4386593002 hasConcept C142724271 @default.
- W4386593002 hasConcept C169760540 @default.
- W4386593002 hasConcept C172680121 @default.
- W4386593002 hasConcept C203014093 @default.
- W4386593002 hasConcept C2522874641 @default.
- W4386593002 hasConcept C2776362945 @default.
- W4386593002 hasConcept C2777053367 @default.
- W4386593002 hasConcept C2777093970 @default.
- W4386593002 hasConcept C2779234561 @default.
- W4386593002 hasConcept C54355233 @default.
- W4386593002 hasConcept C71924100 @default.
- W4386593002 hasConcept C86803240 @default.
- W4386593002 hasConceptScore W4386593002C105702510 @default.
- W4386593002 hasConceptScore W4386593002C142724271 @default.
- W4386593002 hasConceptScore W4386593002C169760540 @default.
- W4386593002 hasConceptScore W4386593002C172680121 @default.
- W4386593002 hasConceptScore W4386593002C203014093 @default.
- W4386593002 hasConceptScore W4386593002C2522874641 @default.
- W4386593002 hasConceptScore W4386593002C2776362945 @default.
- W4386593002 hasConceptScore W4386593002C2777053367 @default.
- W4386593002 hasConceptScore W4386593002C2777093970 @default.
- W4386593002 hasConceptScore W4386593002C2779234561 @default.
- W4386593002 hasConceptScore W4386593002C54355233 @default.
- W4386593002 hasConceptScore W4386593002C71924100 @default.
- W4386593002 hasConceptScore W4386593002C86803240 @default.
- W4386593002 hasIssue "16" @default.
- W4386593002 hasLocation W43865930021 @default.
- W4386593002 hasLocation W43865930022 @default.
- W4386593002 hasOpenAccess W4386593002 @default.
- W4386593002 hasPrimaryLocation W43865930021 @default.
- W4386593002 hasRelatedWork W1996666674 @default.
- W4386593002 hasRelatedWork W2028903898 @default.
- W4386593002 hasRelatedWork W2046134697 @default.
- W4386593002 hasRelatedWork W2047262515 @default.
- W4386593002 hasRelatedWork W2069306062 @default.
- W4386593002 hasRelatedWork W2301148815 @default.
- W4386593002 hasRelatedWork W2793181185 @default.
- W4386593002 hasRelatedWork W2807967552 @default.
- W4386593002 hasRelatedWork W2914968650 @default.
- W4386593002 hasRelatedWork W2998846694 @default.
- W4386593002 hasVolume "34" @default.
- W4386593002 isParatext "false" @default.
- W4386593002 isRetracted "false" @default.
- W4386593002 workType "article" @default.