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- W4386593087 abstract "Abstract Background Vasopressor plays a crucial role in septic shock. However, the time for vasopressor initiation remains controversial. We conducted a systematic review and meta-analysis to explore its initiation timing for septic shock patients. Methods PubMed, Cochrane Library, Embase, and Web of Sciences were searched from inception to July 12 nd , 2023 for relevant studies. Primary outcome was short-term mortality. Meta-analysis was performed using Stata 15.0. Results Twenty-three studies were assessed, including 2 RCTs and 21 cohort studies. The early group resulted in lower short-term mortality than the late group [OR (95%CI) =0.775 (0.673, 0.893), p = 0.000, I2 = 67.8%]. The significance existed in the norepinephrine and vasopressin in sub-group analysis. No significant difference was considered in the association between each hour’s vasopressor delay and mortality [OR (95%CI) =1.02 (0.99, 1.051), p = 0.195, I2 = 57.5%]. The early group had an earlier achievement of target MAP ( p < 0.001), shorter vasopressor use duration ( p < 0.001), lower serum lactate level at 24 h (p = 0.003), lower incidence of kidney injury ( p = 0.001) and RRT use ( p = 0.022), longer ventilation-free days to 28 days ( p < 0.001). Conclusions Early initiation of vasopressor (1-6 h within septic shock onset) would be more beneficial to septic shock patients. The conclusion needs to be further validated by more well-designed RCTs." @default.
- W4386593087 created "2023-09-12" @default.
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- W4386593087 date "2023-09-04" @default.
- W4386593087 modified "2023-10-14" @default.
- W4386593087 title "Initiation timing of vasopressor in patients with septic shock: a systematic review and meta-analysis" @default.
- W4386593087 doi "https://doi.org/10.1097/shk.0000000000002214" @default.
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- W4386593087 hasPublicationYear "2023" @default.
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