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• W4386593239 abstract "Cytochrome c oxidase (CcO) is a large membrane-bound hemeprotein that catalyzes the reduction of dioxygen to water. Unlike classical dioxygen binding hemeproteins with a heme b group in their active sites, CcO has a unique binuclear center (BNC) composed of a copper atom (CuB) and a heme a3 iron, where O2 binds and is reduced to water. CO is a versatile O2 surrogate in ligand binding and escape reactions. Previous time-resolved spectroscopic studies of the CO complexes of bovine CcO (bCcO) revealed that photolyzing CO from the heme a3 iron leads to a metastable intermediate (CuB-CO), where CO is bound to CuB, before it escapes out of the BNC. Here, with a pump-probe based time-resolved serial femtosecond X-ray crystallography, we detected a geminate photoproduct of the bCcO-CO complex, where CO is dissociated from the heme a3 iron and moved to a temporary binding site midway between the CuB and the heme a3 iron, while the locations of the two metal centers and the conformation of Helix-X, housing the proximal histidine ligand of the heme a3 iron, remain in the CO complex state. This new structure, combined with other reported structures of bCcO, allows for a clearer definition of the ligand dissociation trajectory as well as the associated protein dynamics." @default.
• W4386593239 created "2023-09-12" @default.
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• W4386593239 date "2023-09-11" @default.
• W4386593239 modified "2023-10-15" @default.
• W4386593239 title "Detection of a Geminate Photoproduct of Bovine Cytochrome <i>c</i> Oxidase by Time-Resolved Serial Femtosecond Crystallography" @default.
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• W4386593239 doi "https://doi.org/10.1021/jacs.3c07803" @default.
• W4386593239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37695261" @default.
• W4386593239 hasPublicationYear "2023" @default.
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