Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386593287> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4386593287 abstract "Abstract Objective This study aimed to investigate whether St. Thomas’ Hospital No. 2 solution (STH2) is equally effective in both young and aged aquaporin-7-knockout (AQP7-KO) mice and the mechanisms by which the intra-myocardial adenosine triphosphate (ATP) content is altered during ischemia without aquaporin-7. Methods In study 1, isolated hearts of male wild-type (WT) and AQP7-KO mice (< 12 weeks old) were Langendorff perfused with 5-min STH2 prior to a 20-min global ischemia (GI) or 25-min GI without STH2. Similarly, in Study 2, hearts from WT and AQP7-KO mice (≥ 24 weeks old) were subjected to 2-min STH2 infusion prior to GI. In study 3, intra-myocardial ATP content was compared before (sham) and after (control or STH2) ischemia in mature WT and AQP7-KO mice. Results In study 1, troponin T levels (ng/g wet weight) of WT and AQP7-KO hearts were significantly lower in the STH2 groups (75.6 ± 45.9 and 80.2 ± 52.2, respectively) than in the GI groups (934.0 ± 341.1 and 1089.3 ± 182.5, respectively). In Study 2, troponin T levels in aged WT and AQP7-KO mice were 566.5 ± 550.0 and 547.8 ± 594.3, respectively ( p = 0.9561). In Study 3, ATP levels (μmol/g protein) in the sham, control, and STH2 AQP7-KO mice groups were 4.45, 2.57, and 3.37, respectively( p = 0.0005). Conclusions The present study revealed the cardio-protective efficacy of STH2 in an experimental model of isolated AQP7-KO young and aged murine hearts. Further, STH2 preserved intra-myocardial ATP during ischemia with Krebs–Henseleit buffer perfusion in the Langendorff setting." @default.
- W4386593287 created "2023-09-12" @default.
- W4386593287 creator A5009901528 @default.
- W4386593287 creator A5017430491 @default.
- W4386593287 creator A5030460869 @default.
- W4386593287 creator A5056079558 @default.
- W4386593287 date "2023-09-11" @default.
- W4386593287 modified "2023-10-12" @default.
- W4386593287 title "Cardioprotective effect of St. Thomas’ Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice" @default.
- W4386593287 cites W1527760132 @default.
- W4386593287 cites W1968550558 @default.
- W4386593287 cites W1971028967 @default.
- W4386593287 cites W2025130873 @default.
- W4386593287 cites W2036863463 @default.
- W4386593287 cites W2082801139 @default.
- W4386593287 cites W2083987985 @default.
- W4386593287 cites W2092435498 @default.
- W4386593287 cites W2096493061 @default.
- W4386593287 cites W2125866590 @default.
- W4386593287 cites W2126806931 @default.
- W4386593287 cites W2128606426 @default.
- W4386593287 cites W2558579535 @default.
- W4386593287 cites W2594512066 @default.
- W4386593287 cites W2766786653 @default.
- W4386593287 cites W2807820262 @default.
- W4386593287 cites W2942497014 @default.
- W4386593287 cites W2982825219 @default.
- W4386593287 cites W3038613158 @default.
- W4386593287 cites W3116662049 @default.
- W4386593287 cites W3165446547 @default.
- W4386593287 cites W4210986025 @default.
- W4386593287 doi "https://doi.org/10.1007/s11748-023-01975-y" @default.
- W4386593287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37691043" @default.
- W4386593287 hasPublicationYear "2023" @default.
- W4386593287 type Work @default.
- W4386593287 citedByCount "0" @default.
- W4386593287 crossrefType "journal-article" @default.
- W4386593287 hasAuthorship W4386593287A5009901528 @default.
- W4386593287 hasAuthorship W4386593287A5017430491 @default.
- W4386593287 hasAuthorship W4386593287A5030460869 @default.
- W4386593287 hasAuthorship W4386593287A5056079558 @default.
- W4386593287 hasBestOaLocation W43865932871 @default.
- W4386593287 hasConcept C115725540 @default.
- W4386593287 hasConcept C126322002 @default.
- W4386593287 hasConcept C134018914 @default.
- W4386593287 hasConcept C144469398 @default.
- W4386593287 hasConcept C154280991 @default.
- W4386593287 hasConcept C185592680 @default.
- W4386593287 hasConcept C36036425 @default.
- W4386593287 hasConcept C42407357 @default.
- W4386593287 hasConcept C500558357 @default.
- W4386593287 hasConcept C541997718 @default.
- W4386593287 hasConcept C71924100 @default.
- W4386593287 hasConceptScore W4386593287C115725540 @default.
- W4386593287 hasConceptScore W4386593287C126322002 @default.
- W4386593287 hasConceptScore W4386593287C134018914 @default.
- W4386593287 hasConceptScore W4386593287C144469398 @default.
- W4386593287 hasConceptScore W4386593287C154280991 @default.
- W4386593287 hasConceptScore W4386593287C185592680 @default.
- W4386593287 hasConceptScore W4386593287C36036425 @default.
- W4386593287 hasConceptScore W4386593287C42407357 @default.
- W4386593287 hasConceptScore W4386593287C500558357 @default.
- W4386593287 hasConceptScore W4386593287C541997718 @default.
- W4386593287 hasConceptScore W4386593287C71924100 @default.
- W4386593287 hasLocation W43865932871 @default.
- W4386593287 hasLocation W43865932872 @default.
- W4386593287 hasOpenAccess W4386593287 @default.
- W4386593287 hasPrimaryLocation W43865932871 @default.
- W4386593287 hasRelatedWork W1738724831 @default.
- W4386593287 hasRelatedWork W1748839846 @default.
- W4386593287 hasRelatedWork W1970792979 @default.
- W4386593287 hasRelatedWork W1999689773 @default.
- W4386593287 hasRelatedWork W2021082817 @default.
- W4386593287 hasRelatedWork W2053747907 @default.
- W4386593287 hasRelatedWork W2409687048 @default.
- W4386593287 hasRelatedWork W2748952813 @default.
- W4386593287 hasRelatedWork W3004814566 @default.
- W4386593287 hasRelatedWork W73810079 @default.
- W4386593287 isParatext "false" @default.
- W4386593287 isRetracted "false" @default.
- W4386593287 workType "article" @default.