FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386593357> ?p ?o ?g. }

• W4386593357 endingPage "3400" @default.
• W4386593357 startingPage "3384" @default.
• W4386593357 abstract "Numerous studies have demonstrated that long non-coding RNAs (lncRNAs) play crucial roles in tumor progression. This study aimed to identify lncRNAs associated with overall survival (OS) and progression-free interval (PFI) in prostate cancer (PCa) patients and to elucidate the driving mechanisms and functions of these lncRNAs. We utilized the TCGA database to screen for lncRNAs linked with OS and PFI. KM survival analysis, ROC curve analysis, and Cox survival analysis were employed to assess the prognostic significance of lncRNAs in PCa patients. We conducted a loss-of-function assay to explore the role of lncRNAs in PCa. Correlation analysis was performed to study the relationship between lncRNAs and immune cell infiltration. Lasso regression analysis was performed to screen proteins which might interact with lncRNAs, while rescue experiments verified the integrity of the signaling pathway. LMNTD2-AS1 was found to be the only lncRNA in PCa patients associated with both OS and PFI with significantly elevated levels in PCa. Elevated LMNTD2-AS1 expression was significantly linked to advanced stage, grade, primary treatment outcomes, residual tumors, and Gleason scores in PCa patients. Moreover, multivariate Cox regression analysis revealed that high LMNTD2-AS1 expression independently predicted PFI in PCa patients. The AUC of LMNTD2-AS1 for predicting 3-year OS and 5-year OS in PCa patients was 0.877 and 0.807, respectively, while for 3-year PFI and 5-year PFI it was 0.751 and 0.727, respectively. Overexpression of LMNTD2-AS1 correlated with infiltration of neutrophils, macrophages, pDC, NK CD56bright cells, and other immune cells. Furthermore, FUS and NRF2 are both potential binding proteins and related signaling pathways downstream of LMNTD2-AS1. Functional experiments demonstrated that LMNTD2-AS1 knockdown significantly inhibited migration, invasion, and proliferation of PCa cells while overexpression of FUS was found to rescue the functional inhibition caused by LMNTD2-AS1 knockdown. LMNTD2-AS1 functions as an oncogene in PCa, influencing patient prognosis and the immune microenvironment; it may regulate immune cell infiltration and promote PCa progression by interacting with the NRF2 signaling pathway via FUS binding." @default.
• W4386593357 created "2023-09-12" @default.
• W4386593357 creator A5000171141 @default.
• W4386593357 creator A5009685575 @default.
• W4386593357 creator A5016199726 @default.
• W4386593357 creator A5041217554 @default.
• W4386593357 creator A5044301848 @default.
• W4386593357 creator A5055298988 @default.
• W4386593357 creator A5062353652 @default.
• W4386593357 creator A5063873193 @default.
• W4386593357 date "2023-01-01" @default.
• W4386593357 modified "2023-09-27" @default.
• W4386593357 title "LMNTD2-AS1 regulates immune cell infiltration and promotes prostate cancer progression by targeting FUS to regulate NRF2 signal pathway." @default.
• W4386593357 cites W2087377443 @default.
• W4386593357 cites W2153825225 @default.
• W4386593357 cites W2162547088 @default.
• W4386593357 cites W2275201463 @default.
• W4386593357 cites W2296809607 @default.
• W4386593357 cites W2337738786 @default.
• W4386593357 cites W2528388077 @default.
• W4386593357 cites W2567987817 @default.
• W4386593357 cites W2757754210 @default.
• W4386593357 cites W2765533007 @default.
• W4386593357 cites W2769011958 @default.
• W4386593357 cites W2810578662 @default.
• W4386593357 cites W2912673373 @default.
• W4386593357 cites W2912991678 @default.
• W4386593357 cites W2919633708 @default.
• W4386593357 cites W2946350543 @default.
• W4386593357 cites W2947794261 @default.
• W4386593357 cites W3008672214 @default.
• W4386593357 cites W3023047081 @default.
• W4386593357 cites W3094829604 @default.
• W4386593357 cites W3179233334 @default.
• W4386593357 cites W3186967626 @default.
• W4386593357 cites W3196895943 @default.
• W4386593357 cites W3199794078 @default.
• W4386593357 cites W4200616585 @default.
• W4386593357 cites W4205918537 @default.
• W4386593357 cites W4289914322 @default.
• W4386593357 cites W4292854306 @default.
• W4386593357 cites W4293490516 @default.
• W4386593357 cites W4306874670 @default.
• W4386593357 cites W4311289013 @default.
• W4386593357 cites W4315754639 @default.
• W4386593357 cites W4361280761 @default.
• W4386593357 cites W4376959262 @default.
• W4386593357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37693143" @default.
• W4386593357 hasPublicationYear "2023" @default.
• W4386593357 type Work @default.
• W4386593357 citedByCount "0" @default.
• W4386593357 crossrefType "journal-article" @default.
• W4386593357 hasAuthorship W4386593357A5000171141 @default.
• W4386593357 hasAuthorship W4386593357A5009685575 @default.
• W4386593357 hasAuthorship W4386593357A5016199726 @default.
• W4386593357 hasAuthorship W4386593357A5041217554 @default.
• W4386593357 hasAuthorship W4386593357A5044301848 @default.
• W4386593357 hasAuthorship W4386593357A5055298988 @default.
• W4386593357 hasAuthorship W4386593357A5062353652 @default.
• W4386593357 hasAuthorship W4386593357A5063873193 @default.
• W4386593357 hasConcept C10515644 @default.
• W4386593357 hasConcept C121332964 @default.
• W4386593357 hasConcept C121608353 @default.
• W4386593357 hasConcept C126322002 @default.
• W4386593357 hasConcept C143998085 @default.
• W4386593357 hasConcept C153400128 @default.
• W4386593357 hasConcept C203014093 @default.
• W4386593357 hasConcept C2780192828 @default.
• W4386593357 hasConcept C502942594 @default.
• W4386593357 hasConcept C50382708 @default.
• W4386593357 hasConcept C71924100 @default.
• W4386593357 hasConcept C86803240 @default.
• W4386593357 hasConcept C8891405 @default.
• W4386593357 hasConcept C97355855 @default.
• W4386593357 hasConceptScore W4386593357C10515644 @default.
• W4386593357 hasConceptScore W4386593357C121332964 @default.
• W4386593357 hasConceptScore W4386593357C121608353 @default.
• W4386593357 hasConceptScore W4386593357C126322002 @default.
• W4386593357 hasConceptScore W4386593357C143998085 @default.
• W4386593357 hasConceptScore W4386593357C153400128 @default.
• W4386593357 hasConceptScore W4386593357C203014093 @default.
• W4386593357 hasConceptScore W4386593357C2780192828 @default.
• W4386593357 hasConceptScore W4386593357C502942594 @default.
• W4386593357 hasConceptScore W4386593357C50382708 @default.
• W4386593357 hasConceptScore W4386593357C71924100 @default.
• W4386593357 hasConceptScore W4386593357C86803240 @default.
• W4386593357 hasConceptScore W4386593357C8891405 @default.
• W4386593357 hasConceptScore W4386593357C97355855 @default.
• W4386593357 hasIssue "8" @default.
• W4386593357 hasLocation W43865933571 @default.
• W4386593357 hasOpenAccess W4386593357 @default.
• W4386593357 hasPrimaryLocation W43865933571 @default.
• W4386593357 hasRelatedWork W2337677096 @default.
• W4386593357 hasRelatedWork W2793295628 @default.
• W4386593357 hasRelatedWork W2896492909 @default.
• W4386593357 hasRelatedWork W2988390324 @default.
• W4386593357 hasRelatedWork W3011827526 @default.
• W4386593357 hasRelatedWork W3012824765 @default.

• next