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- W4386596056 abstract "Selenium-enriched polysaccharides from Pyracantha fortuneana (SePFP) has many beneficial physiological activities, but how it improves the aging associated abnormal lipid metabolism is still unclear. Therefore, we explored the mechanisms of the regulatory role of SePFP on liver lipid accumulation in aging mice.60 naturally aged C57BL/6J male mice were divided into 6 groups: adult group, aging group (21-month-old mice), aging mice treated with low-, medium- and high-doses of SePFP (SePFP-L, SePFP-M, SePFP-H), and aging mice treated with resveratrol (RSV). SePFP and RSV were administrated daily via oral gavage from 16 to 21 months old. The parameters of energy metabolism were measured in all mice before sacrifice, and liver tissues were collected to determine the levels of metabolism-related enzymes by real-time PCR and Western blot.We found that SePFP significantly reduced the body weight, liver to bodyweight ratio, and white fat to body weight ratio in aging mice. SePFP also down-regulated the triglycerides and cholesterol levels in liver and serum, and decreased respiratory quotient in aging mice. The mechanism of SePFP regulating lipid metabolism was mainly through promoting fatty acid transportation to mitochondria and enhancing mitochondrial β-oxidation and ketone body production.SePFP attenuates liver lipid deposition in aging mice by enhancing hepatic mitochondrial β-oxidation." @default.
- W4386596056 created "2023-09-12" @default.
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- W4386596056 date "2023-01-01" @default.
- W4386596056 modified "2023-10-09" @default.
- W4386596056 title "Selenium-enriched Polysaccharides from <i>Pyracantha fortuneana</i> (SePFP) Ameliorated Hepatic Lipid Accumulation through Enhancing Mitochondrial Fatty Acid β-Oxidation in Aging Mice" @default.
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- W4386596056 doi "https://doi.org/10.5650/jos.ess23065" @default.
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