Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386596810> ?p ?o ?g. }
- W4386596810 abstract "Abstract Fibrous networks constructed from high aspect ratio protein building blocks are ubiquitous in nature. Despite this ubiquity, the functional advantage of such building blocks over globular proteins is not understood. To answer this question, we engineered hydrogel network building blocks with varying numbers of protein L domains to control the aspect ratio. The mechanical and structural properties of photochemically crosslinked protein L networks were then characterised using shear rheology and small angle neutron scattering. We show that aspect ratio is a crucial property that defines network architecture and mechanics, by shifting the formation from translationally diffusion dominated to rotationally diffusion dominated. Additionally, we demonstrate that a similar transition is observed in the model living system: fibrin blood clot networks. The functional advantages of this transition are increased mechanical strength and the rapid assembly of homogenous networks above a critical protein concentration, crucial for in vivo biological processes such as blood clotting. In addition, manipulating aspect ratio also provides a parameter in the design of future bio-mimetic and bio-inspired materials." @default.
- W4386596810 created "2023-09-12" @default.
- W4386596810 creator A5008277035 @default.
- W4386596810 creator A5019584549 @default.
- W4386596810 creator A5023183800 @default.
- W4386596810 creator A5028176645 @default.
- W4386596810 creator A5041373558 @default.
- W4386596810 creator A5041622745 @default.
- W4386596810 creator A5064731858 @default.
- W4386596810 creator A5072031026 @default.
- W4386596810 creator A5085201520 @default.
- W4386596810 creator A5086174439 @default.
- W4386596810 creator A5090457828 @default.
- W4386596810 date "2023-09-11" @default.
- W4386596810 modified "2023-09-28" @default.
- W4386596810 title "Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks" @default.
- W4386596810 cites W1494873915 @default.
- W4386596810 cites W177879061 @default.
- W4386596810 cites W1825294361 @default.
- W4386596810 cites W1907490470 @default.
- W4386596810 cites W1913497435 @default.
- W4386596810 cites W1972282939 @default.
- W4386596810 cites W1974379786 @default.
- W4386596810 cites W1976570489 @default.
- W4386596810 cites W1982883570 @default.
- W4386596810 cites W1985324105 @default.
- W4386596810 cites W1988052143 @default.
- W4386596810 cites W2016667239 @default.
- W4386596810 cites W2019560744 @default.
- W4386596810 cites W2023108847 @default.
- W4386596810 cites W2035066110 @default.
- W4386596810 cites W2047803126 @default.
- W4386596810 cites W2050410320 @default.
- W4386596810 cites W2054828583 @default.
- W4386596810 cites W2057852412 @default.
- W4386596810 cites W2058498396 @default.
- W4386596810 cites W2066823554 @default.
- W4386596810 cites W2068607701 @default.
- W4386596810 cites W2070403068 @default.
- W4386596810 cites W2070537485 @default.
- W4386596810 cites W2076245490 @default.
- W4386596810 cites W2094687997 @default.
- W4386596810 cites W2099014270 @default.
- W4386596810 cites W2101287554 @default.
- W4386596810 cites W2105743928 @default.
- W4386596810 cites W2106246537 @default.
- W4386596810 cites W2109013102 @default.
- W4386596810 cites W2120877547 @default.
- W4386596810 cites W2132237810 @default.
- W4386596810 cites W2135131858 @default.
- W4386596810 cites W2154036638 @default.
- W4386596810 cites W2154114211 @default.
- W4386596810 cites W2154399150 @default.
- W4386596810 cites W2160253662 @default.
- W4386596810 cites W2163802608 @default.
- W4386596810 cites W2338438098 @default.
- W4386596810 cites W2515269884 @default.
- W4386596810 cites W2564804316 @default.
- W4386596810 cites W2572149156 @default.
- W4386596810 cites W2593123705 @default.
- W4386596810 cites W2749081053 @default.
- W4386596810 cites W2765347699 @default.
- W4386596810 cites W2800160491 @default.
- W4386596810 cites W2807130535 @default.
- W4386596810 cites W2807227931 @default.
- W4386596810 cites W2942926972 @default.
- W4386596810 cites W2949754549 @default.
- W4386596810 cites W2951694877 @default.
- W4386596810 cites W2978761657 @default.
- W4386596810 cites W3014790666 @default.
- W4386596810 cites W3035567938 @default.
- W4386596810 cites W3050709087 @default.
- W4386596810 cites W3081601252 @default.
- W4386596810 cites W3132482680 @default.
- W4386596810 cites W3134075574 @default.
- W4386596810 cites W3174269902 @default.
- W4386596810 cites W3194358388 @default.
- W4386596810 cites W4206249603 @default.
- W4386596810 cites W4211237975 @default.
- W4386596810 cites W4213041232 @default.
- W4386596810 cites W4231988980 @default.
- W4386596810 cites W4245280129 @default.
- W4386596810 cites W4250817735 @default.
- W4386596810 cites W4281790889 @default.
- W4386596810 cites W4283323057 @default.
- W4386596810 cites W4292649659 @default.
- W4386596810 cites W4297224604 @default.
- W4386596810 cites W4328022351 @default.
- W4386596810 cites W4381489525 @default.
- W4386596810 doi "https://doi.org/10.1038/s41467-023-40921-7" @default.
- W4386596810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37696784" @default.
- W4386596810 hasPublicationYear "2023" @default.
- W4386596810 type Work @default.
- W4386596810 citedByCount "0" @default.
- W4386596810 crossrefType "journal-article" @default.
- W4386596810 hasAuthorship W4386596810A5008277035 @default.
- W4386596810 hasAuthorship W4386596810A5019584549 @default.
- W4386596810 hasAuthorship W4386596810A5023183800 @default.
- W4386596810 hasAuthorship W4386596810A5028176645 @default.
- W4386596810 hasAuthorship W4386596810A5041373558 @default.