FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386600012> ?p ?o ?g. }

• W4386600012 endingPage "360" @default.
• W4386600012 startingPage "359" @default.
• W4386600012 abstract "Metabolic bone disease in chronic neurological disorders remains an active area of research now. Parkinson’s disease (PD) is one of the commonest neurological disorders, characterized by tremors, rigidity, and slowness of movement and is associated with significant morbidity in the advanced stages. On the other hand, osteoporosis, which is characterized by low bone mineral density (BMD) (≤2.5 T-score and Z-score), a surrogate marker of decreased bone strength, is another chronic condition common among the elderly population. These two conditions can go hand in hand in the elderly population and confer a significant risk of fragility fracture and morbidity. PD is associated with a significant risk of lower BMD at all the sites (femoral neck, lumbar spine, and total hip region) in a recently performed meta-analysis.[1] PD patients have consistently increased fracture risk at different sites, such as vertebral and hip fractures, compared to controls.[2,3] Apart from low BMD, the propensity to repeated falls, decreased muscle strength, low vitamin D levels, and drugs like levodopa can play an important role in the fracture occurrence in PD.[4] All these factors often are present in tandem with PD patients, making them vulnerable to osteoporotic fractures. Moreover, PD by itself can increase fracture risk in a BMD-independent manner.[5] Thus, it is essential to look for additional factors beyond BMD. A study by Schini and colleagues also suggested to include PD as an independent factor in the Fracture risk assessment (FRAX) score calculations. The lowering of BMD in PD is often evident at an early stage of the disease,[3,6] but the outcomes are not conclusive to provide evidence-based recommendations on early screening for osteoporosis in all patients with PD. In this context, it is interesting to see if newer tools like trabecular bone score (TBS) adds to the diagnosis of osteoporosis in PD. TBS is a relatively new tool which uses pixel-to-pixel variation in the gray area level in the lumbar spine image derived from dual-energy X-ray absorptiometry. It gives a better idea about the skeletal textur, is an indirect indicator of bone microarchitectures, and improves the fracture prediction independent of BMD measurements.[7] In this issue of this journal, the study by Sooragonda BG, et al. has explored the difference in BMD, TBS along with hip structural analysis in male PD patients compared to healthy controls (ref, current study[8]). The interesting finding is lower TBS in PD patients despite no significant difference in BMD as compared to controls. This study also found a lower trend of TBS in severe PD but did not reach statistical significance, possibly due to a low sample size. Thus, the study explored a new tool (TBS) in a relatively understudied area of osteoporosis in men that too in a vulnerable group of PD patients. This study further consolidated the finding of low vitamin D in PD patients with severe disease. However, this certainly does not explain the finding of the low TBS in this population. BMD data in PD has always been conflicting and BMD seldom reflects the microarchitectural deterioration in neurological disease, for which TBS can be a useful adjunct. However, as discussed earlier, many factors other than bone-related parameters are involved in the pathogenesis of osteoporosis and fracture in PD; fracture data is certainly required. It would be very much interesting to see the fracture prevalence in the PD group as compared to controls and whether this correlates with low TBS. Moreover, a longitudinal follow-up of this cohort is warranted to gain further insight if low TBS can predict incident fracture in PD population. Moreover, if we want to provide good quality of life to PD patients, the fracture has to be prevented. Whether medications bisphosphonates will have any role? This remains an interesting point to ponder and whether low TBS at baseline can be a guide for therapeutic intervention? Possibly, we need multiprong strategies including strict fall prevention measure, improvement in muscle strength through structured exercise programs including adequate vitamin D supplementation. There is an ongoing randomized clinical trial going on the impact of bisphosphonates (zoledronic acid) in PD patients, which might provide evidence for therapeutic intervention in PD patients.[9] Having said that, bone strength and bone quality measurement should be considered in PD patients, preferably at an early stage to prevent fracture and ongoing search should continue to have a reasonable predictive tool or model for clinical use." @default.
• W4386600012 created "2023-09-12" @default.
• W4386600012 creator A5005666207 @default.
• W4386600012 creator A5052968867 @default.
• W4386600012 date "2023-01-01" @default.
• W4386600012 modified "2023-09-29" @default.
• W4386600012 title "Osteoporosis in Parkinson’s Disease: In Search of the Best Prediction Tool" @default.
• W4386600012 cites W1963797324 @default.
• W4386600012 cites W2896730812 @default.
• W4386600012 cites W3016584995 @default.
• W4386600012 cites W3022779897 @default.
• W4386600012 cites W3039769869 @default.
• W4386600012 cites W3107349033 @default.
• W4386600012 cites W4312204693 @default.
• W4386600012 cites W4384930134 @default.
• W4386600012 doi "https://doi.org/10.4103/aian.aian_400_23" @default.
• W4386600012 hasPublicationYear "2023" @default.
• W4386600012 type Work @default.
• W4386600012 citedByCount "0" @default.
• W4386600012 crossrefType "journal-article" @default.
• W4386600012 hasAuthorship W4386600012A5005666207 @default.
• W4386600012 hasAuthorship W4386600012A5052968867 @default.
• W4386600012 hasBestOaLocation W43866000121 @default.
• W4386600012 hasConcept C124490489 @default.
• W4386600012 hasConcept C126322002 @default.
• W4386600012 hasConcept C1862650 @default.
• W4386600012 hasConcept C2775854910 @default.
• W4386600012 hasConcept C2776541429 @default.
• W4386600012 hasConcept C2776886416 @default.
• W4386600012 hasConcept C2777083390 @default.
• W4386600012 hasConcept C2777525943 @default.
• W4386600012 hasConcept C2778885795 @default.
• W4386600012 hasConcept C2908647359 @default.
• W4386600012 hasConcept C2994343686 @default.
• W4386600012 hasConcept C71924100 @default.
• W4386600012 hasConcept C99454951 @default.
• W4386600012 hasConceptScore W4386600012C124490489 @default.
• W4386600012 hasConceptScore W4386600012C126322002 @default.
• W4386600012 hasConceptScore W4386600012C1862650 @default.
• W4386600012 hasConceptScore W4386600012C2775854910 @default.
• W4386600012 hasConceptScore W4386600012C2776541429 @default.
• W4386600012 hasConceptScore W4386600012C2776886416 @default.
• W4386600012 hasConceptScore W4386600012C2777083390 @default.
• W4386600012 hasConceptScore W4386600012C2777525943 @default.
• W4386600012 hasConceptScore W4386600012C2778885795 @default.
• W4386600012 hasConceptScore W4386600012C2908647359 @default.
• W4386600012 hasConceptScore W4386600012C2994343686 @default.
• W4386600012 hasConceptScore W4386600012C71924100 @default.
• W4386600012 hasConceptScore W4386600012C99454951 @default.
• W4386600012 hasIssue "4" @default.
• W4386600012 hasLocation W43866000121 @default.
• W4386600012 hasOpenAccess W4386600012 @default.
• W4386600012 hasPrimaryLocation W43866000121 @default.
• W4386600012 hasRelatedWork W2026132755 @default.
• W4386600012 hasRelatedWork W2027977119 @default.
• W4386600012 hasRelatedWork W2053842375 @default.
• W4386600012 hasRelatedWork W2287839548 @default.
• W4386600012 hasRelatedWork W2348327665 @default.
• W4386600012 hasRelatedWork W2412158022 @default.
• W4386600012 hasRelatedWork W2566312653 @default.
• W4386600012 hasRelatedWork W2947117835 @default.
• W4386600012 hasRelatedWork W3040608001 @default.
• W4386600012 hasRelatedWork W4319063456 @default.
• W4386600012 hasVolume "26" @default.
• W4386600012 isParatext "false" @default.
• W4386600012 isRetracted "false" @default.
• W4386600012 workType "article" @default.