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- W4386600518 abstract "Abstract Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that is generally associated with poor prognosis in affected patients. Unfortunately, recently approved immune checkpoint inhibitors are efficacious in only a subset of patients. A surrogate marker for tumor-specific CD8 + T cells is urgently required to clarify the mechanisms of antitumor immune responses and help prognosticate TNBC patients. Here, we conducted a comparative interrogation of TNBC to evaluate the potential of CD39 as a surrogate marker of tumor-specific T cells. We first used flow cytometry to study more than 12,000 tumor-specific CD8 + T cells within both peripheral blood mononuclear cells and tumor-infiltrating lymphocyte populations in a mouse TNBC model and found that more than 99% of tumor-specific CD8 + T cells were present in the CD39 + subset. Multiplex immunohistochemistry/immunofluorescence staining demonstrated that the proportion of CD39 + CD8 + T cells in human TNBC tumors correlated with improved overall survival. The frequencies of other CD39 + immune infiltrates, such as CD39 + CD68 + macrophages, also correlated with improved OS. Thus CD39 + CD8 + T cells might help predict prognosis in patients with TNBC." @default.
- W4386600518 created "2023-09-12" @default.
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- W4386600518 date "2023-09-11" @default.
- W4386600518 modified "2023-10-03" @default.
- W4386600518 title "The prognostic value of CD39+CD8+ T cells as a potential surrogate marker of tumor-specific T cells in Asian triple-negative breast cancer" @default.
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- W4386600518 doi "https://doi.org/10.21203/rs.3.rs-3336490/v1" @default.
- W4386600518 hasPublicationYear "2023" @default.
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