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- W4386601035 abstract "Abstract Recently, the copper-induced regulated cell death form that depends on mitochondrial respiration was identified as cuproptosis. However, the potential roles of cuproptosis-related genes(CRGs) with tumor prognosis and tumor microenvironment(TME) in colon cancer(CC) patients remain unclear. From four independent databases, we characterized the set of CRGs in 1124 CC samples from the fields of genetic and transcriptional, then evaluated their expression patterns. We identified two CRGclusters, and found distinguishing clinicopathological features, prognosis, and TME cell infiltrating characteristics correlated with CRGs expression. Moreover, a predictable risk score for overall-survival (OS) was established and its predictive capability in CC patients was validated. Subsequently, the nomogram was constructed to improve the risk score's clinical features applicability. The high-risk level, characterized by an increased proportion of mutation burden, microsatellite instability-high (MSI-H), and immune cell infiltration, indicates the potential for immunotherapy response. Our analysis of CRGs in CC demonstrated their potential roles in the tumor-immune-stromal microenvironment, clinicopathological features, and prognosis. These findings may improve our understanding of CRGs in CC and pave a new path for the assessment of prognosis and the development of more effective immunotherapy strategies." @default.
- W4386601035 created "2023-09-12" @default.
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- W4386601035 date "2023-09-11" @default.
- W4386601035 modified "2023-09-29" @default.
- W4386601035 title "Identification and Validation of Cuproptosis-Related Genes in Prognosis and immune microenvironment in colon cancer patients" @default.
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- W4386601035 doi "https://doi.org/10.21203/rs.3.rs-3331236/v1" @default.
- W4386601035 hasPublicationYear "2023" @default.
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