Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386601044> ?p ?o ?g. }
- W4386601044 endingPage "3376.e11" @default.
- W4386601044 startingPage "3360" @default.
- W4386601044 abstract "Aging is associated with progressive phenotypic changes. Virtually all cellular phenotypes are produced by proteins, and their structural alterations can lead to age-related diseases. However, we still lack comprehensive knowledge of proteins undergoing structural-functional changes during cellular aging and their contributions to age-related phenotypes. Here, we conducted proteome-wide analysis of early age-related protein structural changes in budding yeast using limited proteolysis-mass spectrometry (LiP-MS). The results, compiled in online ProtAge catalog, unraveled age-related functional changes in regulators of translation, protein folding, and amino acid metabolism. Mechanistically, we found that folded glutamate synthase Glt1 polymerizes into supramolecular self-assemblies during aging, causing breakdown of cellular amino acid homeostasis. Inhibiting Glt1 polymerization by mutating the polymerization interface restored amino acid levels in aged cells, attenuated mitochondrial dysfunction, and led to lifespan extension. Altogether, this comprehensive map of protein structural changes enables identifying mechanisms of age-related phenotypes and offers opportunities for their reversal." @default.
- W4386601044 created "2023-09-12" @default.
- W4386601044 creator A5002109405 @default.
- W4386601044 creator A5002575793 @default.
- W4386601044 creator A5003394011 @default.
- W4386601044 creator A5007075265 @default.
- W4386601044 creator A5007270321 @default.
- W4386601044 creator A5009921084 @default.
- W4386601044 creator A5016827825 @default.
- W4386601044 creator A5018575502 @default.
- W4386601044 creator A5019343237 @default.
- W4386601044 creator A5021192161 @default.
- W4386601044 creator A5025896431 @default.
- W4386601044 creator A5026135455 @default.
- W4386601044 creator A5030987435 @default.
- W4386601044 creator A5031677399 @default.
- W4386601044 creator A5037584322 @default.
- W4386601044 creator A5038897453 @default.
- W4386601044 creator A5047982892 @default.
- W4386601044 creator A5052175889 @default.
- W4386601044 creator A5064498279 @default.
- W4386601044 creator A5065479324 @default.
- W4386601044 creator A5069742339 @default.
- W4386601044 creator A5073719214 @default.
- W4386601044 creator A5084914720 @default.
- W4386601044 creator A5089549351 @default.
- W4386601044 date "2023-09-01" @default.
- W4386601044 modified "2023-10-18" @default.
- W4386601044 title "Global analysis of aging-related protein structural changes uncovers enzyme-polymerization-based control of longevity" @default.
- W4386601044 cites W1179276624 @default.
- W4386601044 cites W1568630971 @default.
- W4386601044 cites W1607969426 @default.
- W4386601044 cites W1962225963 @default.
- W4386601044 cites W1964895626 @default.
- W4386601044 cites W1967960279 @default.
- W4386601044 cites W1977496944 @default.
- W4386601044 cites W1981747529 @default.
- W4386601044 cites W1981840094 @default.
- W4386601044 cites W1982185581 @default.
- W4386601044 cites W1988291043 @default.
- W4386601044 cites W1993009001 @default.
- W4386601044 cites W1995790874 @default.
- W4386601044 cites W2003516452 @default.
- W4386601044 cites W2013947447 @default.
- W4386601044 cites W2014810706 @default.
- W4386601044 cites W2015115860 @default.
- W4386601044 cites W2016819009 @default.
- W4386601044 cites W2017529721 @default.
- W4386601044 cites W2017783166 @default.
- W4386601044 cites W2041786202 @default.
- W4386601044 cites W2042838776 @default.
- W4386601044 cites W2043694037 @default.
- W4386601044 cites W2046866726 @default.
- W4386601044 cites W2074467340 @default.
- W4386601044 cites W2076945013 @default.
- W4386601044 cites W2082143788 @default.
- W4386601044 cites W2089145020 @default.
- W4386601044 cites W2105375182 @default.
- W4386601044 cites W2108584575 @default.
- W4386601044 cites W2114370367 @default.
- W4386601044 cites W2115998813 @default.
- W4386601044 cites W2119420834 @default.
- W4386601044 cites W2122289467 @default.
- W4386601044 cites W2126519916 @default.
- W4386601044 cites W2126525177 @default.
- W4386601044 cites W2129178024 @default.
- W4386601044 cites W2129888458 @default.
- W4386601044 cites W2135636602 @default.
- W4386601044 cites W2140948740 @default.
- W4386601044 cites W2142437744 @default.
- W4386601044 cites W2142604092 @default.
- W4386601044 cites W2146503498 @default.
- W4386601044 cites W2146721676 @default.
- W4386601044 cites W2147984622 @default.
- W4386601044 cites W2152231829 @default.
- W4386601044 cites W2154046032 @default.
- W4386601044 cites W2154164675 @default.
- W4386601044 cites W2160897547 @default.
- W4386601044 cites W2164709221 @default.
- W4386601044 cites W2169805130 @default.
- W4386601044 cites W2170392103 @default.
- W4386601044 cites W2186330137 @default.
- W4386601044 cites W2189788457 @default.
- W4386601044 cites W2236156346 @default.
- W4386601044 cites W2329017376 @default.
- W4386601044 cites W2469060224 @default.
- W4386601044 cites W2470958832 @default.
- W4386601044 cites W2517275410 @default.
- W4386601044 cites W2565783117 @default.
- W4386601044 cites W2565793933 @default.
- W4386601044 cites W2590059905 @default.
- W4386601044 cites W2595193911 @default.
- W4386601044 cites W2613629789 @default.
- W4386601044 cites W2708317524 @default.
- W4386601044 cites W2734356283 @default.
- W4386601044 cites W2741175162 @default.
- W4386601044 cites W2749545656 @default.
- W4386601044 cites W2765107589 @default.