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- W4386601361 abstract "<p>CD8<sup>+</sup> T cells mediate a robust anti-PDT response and transfer antitumor activity. <b>A,</b> In mice bearing AB12 tumors, administration of CD8<sup>+</sup>-depleting antibodies prior to PDT (<i>n</i> = 13) impeded tumor response compared with mice treated with isotype control prior to PDT (<i>n</i> = 12; <i>P</i> < 0.001). The median time of tumor growth to the 400 mm<sup>3</sup> endpoint was 4–5 days in mice treated with CD8<sup>+</sup>-depleting antibodies (<i>n</i> = 9) or isotype (<i>n</i> = 3) in the absence of PDT. <b>B,</b> T cells were isolated from the spleens of naïve mice, tumored mice, or mice whose tumors were treated with PDT or TI/PDT and transferred alongside AB12 cells into recipient mice. T cells isolated from the spleen of mice bearing tumors generated growth delays in recipient mice compared with the T cells isolated from the naïve group; this growth delay was maintained when the T cells were alternatively harvested from PDT or TI/PDT treated mice relative to the naïve group. <i>n</i> = 5 recipient mice per group.</p>" @default.
- W4386601361 created "2023-09-12" @default.
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- W4386601361 date "2023-09-11" @default.
- W4386601361 modified "2023-10-18" @default.
- W4386601361 title "FIGURE 4 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy" @default.
- W4386601361 doi "https://doi.org/10.1158/2767-9764.24119253.v1" @default.
- W4386601361 hasPublicationYear "2023" @default.
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