Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386601430> ?p ?o ?g. }
- W4386601430 endingPage "2498" @default.
- W4386601430 startingPage "2498" @default.
- W4386601430 abstract "Obesity is a serious chronic disease and an independent risk factor for the new onset and progression of chronic kidney disease (CKD). CKD prevalence is expected to increase, at least partly due to the continuous rise in the prevalence of obesity. The concept of obesity-related kidney disease (OKD) has been introduced to describe the still incompletely understood interplay between obesity, CKD, and other cardiometabolic conditions, including risk factors for OKD and cardiovascular disease, such as diabetes and hypertension. Current therapeutics target obesity and CKD individually. Non-pharmacological interventions play a major part, but the efficacy and clinical applicability of lifestyle changes and metabolic surgery remain debatable, because the strategies do not benefit everyone, and it remains questionable whether lifestyle changes can be sustained in the long term. Pharmacological interventions, such as sodium-glucose co-transporter 2 inhibitors and the non-steroidal mineralocorticoid receptor antagonist finerenone, provide kidney protection but have limited or no impact on body weight. Medicines based on glucagon-like peptide-1 (GLP-1) induce clinically relevant weight loss and may also offer kidney benefits. An urgent medical need remains for investigations to better understand the intertwined pathophysiologies in OKD, paving the way for the best possible therapeutic strategies in this increasingly prevalent disease complex." @default.
- W4386601430 created "2023-09-12" @default.
- W4386601430 creator A5031624913 @default.
- W4386601430 creator A5037459678 @default.
- W4386601430 creator A5038074967 @default.
- W4386601430 creator A5069378108 @default.
- W4386601430 creator A5090783212 @default.
- W4386601430 date "2023-09-09" @default.
- W4386601430 modified "2023-10-17" @default.
- W4386601430 title "Obesity-Related Kidney Disease: Current Understanding and Future Perspectives" @default.
- W4386601430 cites W1769943683 @default.
- W4386601430 cites W1967094568 @default.
- W4386601430 cites W1977314871 @default.
- W4386601430 cites W1989400130 @default.
- W4386601430 cites W1992123574 @default.
- W4386601430 cites W1994651976 @default.
- W4386601430 cites W2004206534 @default.
- W4386601430 cites W2007684928 @default.
- W4386601430 cites W2023005022 @default.
- W4386601430 cites W2034258292 @default.
- W4386601430 cites W2037142399 @default.
- W4386601430 cites W2038650801 @default.
- W4386601430 cites W2038961236 @default.
- W4386601430 cites W2051846093 @default.
- W4386601430 cites W2063868657 @default.
- W4386601430 cites W2073394239 @default.
- W4386601430 cites W2081415617 @default.
- W4386601430 cites W2091142003 @default.
- W4386601430 cites W2111346120 @default.
- W4386601430 cites W2113507924 @default.
- W4386601430 cites W2114614037 @default.
- W4386601430 cites W2121622684 @default.
- W4386601430 cites W2123931921 @default.
- W4386601430 cites W2125854867 @default.
- W4386601430 cites W2130492862 @default.
- W4386601430 cites W2136417592 @default.
- W4386601430 cites W2141720478 @default.
- W4386601430 cites W2146264128 @default.
- W4386601430 cites W2292633092 @default.
- W4386601430 cites W2306940576 @default.
- W4386601430 cites W2333284976 @default.
- W4386601430 cites W2345368448 @default.
- W4386601430 cites W2394582105 @default.
- W4386601430 cites W2404306813 @default.
- W4386601430 cites W2415080161 @default.
- W4386601430 cites W2425644022 @default.
- W4386601430 cites W2519510391 @default.
- W4386601430 cites W2521343666 @default.
- W4386601430 cites W2528280726 @default.
- W4386601430 cites W2571040143 @default.
- W4386601430 cites W2581895415 @default.
- W4386601430 cites W2587125180 @default.
- W4386601430 cites W2588237306 @default.
- W4386601430 cites W2611213971 @default.
- W4386601430 cites W2754041380 @default.
- W4386601430 cites W2782974118 @default.
- W4386601430 cites W2785189031 @default.
- W4386601430 cites W2808915250 @default.
- W4386601430 cites W2825161255 @default.
- W4386601430 cites W2883368448 @default.
- W4386601430 cites W2883371150 @default.
- W4386601430 cites W2895752892 @default.
- W4386601430 cites W2897257410 @default.
- W4386601430 cites W2897849508 @default.
- W4386601430 cites W2899067744 @default.
- W4386601430 cites W2900749595 @default.
- W4386601430 cites W2901979245 @default.
- W4386601430 cites W2905206992 @default.
- W4386601430 cites W2910107074 @default.
- W4386601430 cites W2911721172 @default.
- W4386601430 cites W2939222610 @default.
- W4386601430 cites W2941131660 @default.
- W4386601430 cites W2942253286 @default.
- W4386601430 cites W2948612418 @default.
- W4386601430 cites W2954049377 @default.
- W4386601430 cites W2959363312 @default.
- W4386601430 cites W2968513998 @default.
- W4386601430 cites W2971051718 @default.
- W4386601430 cites W2978840913 @default.
- W4386601430 cites W2989595227 @default.
- W4386601430 cites W2993908729 @default.
- W4386601430 cites W3003844726 @default.
- W4386601430 cites W3007322974 @default.
- W4386601430 cites W3008074101 @default.
- W4386601430 cites W3008279587 @default.
- W4386601430 cites W3017135149 @default.
- W4386601430 cites W3029187477 @default.
- W4386601430 cites W3045841176 @default.
- W4386601430 cites W3088173406 @default.
- W4386601430 cites W3092068238 @default.
- W4386601430 cites W3093042356 @default.
- W4386601430 cites W3094429645 @default.
- W4386601430 cites W3096289954 @default.
- W4386601430 cites W3097384753 @default.
- W4386601430 cites W3102435759 @default.
- W4386601430 cites W3105770573 @default.
- W4386601430 cites W3112405194 @default.
- W4386601430 cites W3113130781 @default.