FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386602783> ?p ?o ?g. }

• W4386602783 abstract "Abstract Neocortical pyramidal neurons are frequently myelinated. Diversity in the topography of axonal myelination in the cerebral cortex has been attributed to a combination of electrophysiological activity, axonal morphology, and neuronal-glial interactions. Previously, we showed that axonal segment length and calibre are critical determinants of fast-spiking interneuron myelination (Stedehouder, J. et al (2019). However, the factors that determine the myelination of individual axonal segments along neocortical pyramidal neurons remain largely unexplored. Here, we used structured illumination microscopy and cell type-specific manipulations to examine the extent to which axonal morphology determines the topography of axonal myelination in mouse neocortical pyramidal neurons. We found that, unlike what was determined for fast-spiking interneurons, the joint combination of axonal calibre and interbranch distance does not predict axonal myelination in pyramidal neurons, rather it provides a minimum threshold for myelination; pyramidal neurons with an axon calibre and interbranch distance lower than 0.24 µm and 19 µm, respectively, are almost never myelinated. Moreover, we further confirmed that these findings in mice also extend to human neocortical pyramidal cell myelination, suggesting that this mechanism is evolutionarily conserved. Taken together, our findings suggest that axonal morphology is highly deterministic of the topography and cell-type specificity of neocortical myelination." @default.
• W4386602783 created "2023-09-12" @default.
• W4386602783 creator A5012878863 @default.
• W4386602783 creator A5014398858 @default.
• W4386602783 creator A5019701642 @default.
• W4386602783 creator A5021185824 @default.
• W4386602783 creator A5039382714 @default.
• W4386602783 creator A5053357834 @default.
• W4386602783 creator A5057815349 @default.
• W4386602783 creator A5058650247 @default.
• W4386602783 creator A5063092847 @default.
• W4386602783 creator A5069691714 @default.
• W4386602783 date "2023-09-11" @default.
• W4386602783 modified "2023-09-27" @default.
• W4386602783 title "A minimum threshold for myelination of pyramidal cells in human and mouse neocortex" @default.
• W4386602783 cites W1833609357 @default.
• W4386602783 cites W1842838667 @default.
• W4386602783 cites W1901712533 @default.
• W4386602783 cites W1966880041 @default.
• W4386602783 cites W1971006243 @default.
• W4386602783 cites W1975719696 @default.
• W4386602783 cites W2002764396 @default.
• W4386602783 cites W2019746827 @default.
• W4386602783 cites W2023469980 @default.
• W4386602783 cites W2028563790 @default.
• W4386602783 cites W2041083111 @default.
• W4386602783 cites W2050139274 @default.
• W4386602783 cites W2053632281 @default.
• W4386602783 cites W2078602583 @default.
• W4386602783 cites W2079111057 @default.
• W4386602783 cites W2082326637 @default.
• W4386602783 cites W2091603506 @default.
• W4386602783 cites W2111651545 @default.
• W4386602783 cites W2147225543 @default.
• W4386602783 cites W2157257192 @default.
• W4386602783 cites W2161266571 @default.
• W4386602783 cites W2166990692 @default.
• W4386602783 cites W2255839289 @default.
• W4386602783 cites W2499449813 @default.
• W4386602783 cites W2582474577 @default.
• W4386602783 cites W2744935059 @default.
• W4386602783 cites W2747829385 @default.
• W4386602783 cites W2749489383 @default.
• W4386602783 cites W2769881657 @default.
• W4386602783 cites W2789414311 @default.
• W4386602783 cites W2793201005 @default.
• W4386602783 cites W2796329722 @default.
• W4386602783 cites W2896363115 @default.
• W4386602783 cites W2944786249 @default.
• W4386602783 cites W2955907034 @default.
• W4386602783 cites W2990705119 @default.
• W4386602783 cites W3120392574 @default.
• W4386602783 cites W4255894213 @default.
• W4386602783 doi "https://doi.org/10.1101/2023.09.09.556989" @default.
• W4386602783 hasPublicationYear "2023" @default.
• W4386602783 type Work @default.
• W4386602783 citedByCount "0" @default.
• W4386602783 crossrefType "posted-content" @default.
• W4386602783 hasAuthorship W4386602783A5012878863 @default.
• W4386602783 hasAuthorship W4386602783A5014398858 @default.
• W4386602783 hasAuthorship W4386602783A5019701642 @default.
• W4386602783 hasAuthorship W4386602783A5021185824 @default.
• W4386602783 hasAuthorship W4386602783A5039382714 @default.
• W4386602783 hasAuthorship W4386602783A5053357834 @default.
• W4386602783 hasAuthorship W4386602783A5057815349 @default.
• W4386602783 hasAuthorship W4386602783A5058650247 @default.
• W4386602783 hasAuthorship W4386602783A5063092847 @default.
• W4386602783 hasAuthorship W4386602783A5069691714 @default.
• W4386602783 hasBestOaLocation W43866027831 @default.
• W4386602783 hasConcept C105702510 @default.
• W4386602783 hasConcept C169760540 @default.
• W4386602783 hasConcept C17077164 @default.
• W4386602783 hasConcept C185263204 @default.
• W4386602783 hasConcept C2777222312 @default.
• W4386602783 hasConcept C2777348757 @default.
• W4386602783 hasConcept C2778437258 @default.
• W4386602783 hasConcept C2778583998 @default.
• W4386602783 hasConcept C2779296341 @default.
• W4386602783 hasConcept C2779530196 @default.
• W4386602783 hasConcept C2781041448 @default.
• W4386602783 hasConcept C2781161787 @default.
• W4386602783 hasConcept C3020251336 @default.
• W4386602783 hasConcept C529278444 @default.
• W4386602783 hasConcept C86803240 @default.
• W4386602783 hasConceptScore W4386602783C105702510 @default.
• W4386602783 hasConceptScore W4386602783C169760540 @default.
• W4386602783 hasConceptScore W4386602783C17077164 @default.
• W4386602783 hasConceptScore W4386602783C185263204 @default.
• W4386602783 hasConceptScore W4386602783C2777222312 @default.
• W4386602783 hasConceptScore W4386602783C2777348757 @default.
• W4386602783 hasConceptScore W4386602783C2778437258 @default.
• W4386602783 hasConceptScore W4386602783C2778583998 @default.
• W4386602783 hasConceptScore W4386602783C2779296341 @default.
• W4386602783 hasConceptScore W4386602783C2779530196 @default.
• W4386602783 hasConceptScore W4386602783C2781041448 @default.
• W4386602783 hasConceptScore W4386602783C2781161787 @default.
• W4386602783 hasConceptScore W4386602783C3020251336 @default.
• W4386602783 hasConceptScore W4386602783C529278444 @default.
• W4386602783 hasConceptScore W4386602783C86803240 @default.
• W4386602783 hasLocation W43866027831 @default.

• next