Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386606009> ?p ?o ?g. }
- W4386606009 endingPage "4120" @default.
- W4386606009 startingPage "4109" @default.
- W4386606009 abstract "The occurrence, progression, and prognosis of colorectal cancer (CRC) are regulated by EGFR-mediated signaling pathways. However, the relationship between the core genes (KRAS/NRAS/BRAF/PIK3CA) status in the signaling pathways and clinicopathological characteristics of CRC patients in Hakka population remains controversial.Patients were genotyped for KRAS (codons 12, 13, 61, 117, and 146), NRAS (codons 12, 61, 117, and 146), BRAF (codons 600), and PIK3CA (codons 542, 545 and 1047) mutations. Clinical records were collected, and clinicopathological characteristic associations were analyzed together with mutations of studied genes.Four hundred and eight patients (256 men and 152 women) were included in the analysis. At least one mutation in the four genes was detected in 216 (52.9%) patients, while none was detected in 192 (47.1%) patients. KRAS, NRAS, BRAF, and PIK3CA mutation status were detected in 190 (46.6%), 11 (2.7%), 10 (2.5%), 34 (8.3%) samples, respectively. KRAS exon 2 had the highest proportion (62.5%). Age, tumor site, tumor size, lymphovascular invasion, and perineural invasion were not associated with gene mutations. KRAS mutations (adjusted OR 1.675, 95% CI 1.017-2.760, P=0.043) and NRAS mutations (adjusted OR 5.183, 95% CI 1.239-21.687, P=0.024) appeared more frequently in patients with distant metastasis. BRAF mutations (adjusted OR 7.224, 95% CI 1.356-38.488, P=0.021) and PIK3CA mutations (adjusted OR 3.811, 95% CI 1.268-11.455, P=0.017) associated with poorly differentiated tumor.KRAS/NRAS mutations are associated with distant metastasis and BRAF/PIK3CA mutations are associated with poor tumor differentiation in CRC. And the results provided a better understanding between clinicopathological characteristics and gene mutations in CRC patients." @default.
- W4386606009 created "2023-09-12" @default.
- W4386606009 creator A5005149399 @default.
- W4386606009 creator A5023632317 @default.
- W4386606009 creator A5037795734 @default.
- W4386606009 creator A5062758299 @default.
- W4386606009 creator A5081743397 @default.
- W4386606009 date "2023-09-01" @default.
- W4386606009 modified "2023-09-27" @default.
- W4386606009 title "KRAS/NRAS Mutations Associated with Distant Metastasis and BRAF/PIK3CA Mutations Associated with Poor Tumor Differentiation in Colorectal Cancer" @default.
- W4386606009 cites W1597604324 @default.
- W4386606009 cites W1955219914 @default.
- W4386606009 cites W1965905026 @default.
- W4386606009 cites W2027689431 @default.
- W4386606009 cites W2029503777 @default.
- W4386606009 cites W2032033547 @default.
- W4386606009 cites W2045403704 @default.
- W4386606009 cites W2095692554 @default.
- W4386606009 cites W2113677807 @default.
- W4386606009 cites W2161097769 @default.
- W4386606009 cites W2164311019 @default.
- W4386606009 cites W2164523473 @default.
- W4386606009 cites W2187184853 @default.
- W4386606009 cites W2234879572 @default.
- W4386606009 cites W2462265227 @default.
- W4386606009 cites W2476010038 @default.
- W4386606009 cites W2502940265 @default.
- W4386606009 cites W2560322684 @default.
- W4386606009 cites W2560449737 @default.
- W4386606009 cites W2604001476 @default.
- W4386606009 cites W2604121843 @default.
- W4386606009 cites W2790369287 @default.
- W4386606009 cites W2801104655 @default.
- W4386606009 cites W2801169819 @default.
- W4386606009 cites W2809048816 @default.
- W4386606009 cites W2897665819 @default.
- W4386606009 cites W2912893085 @default.
- W4386606009 cites W2946647961 @default.
- W4386606009 cites W2956064581 @default.
- W4386606009 cites W2969669738 @default.
- W4386606009 cites W2971457693 @default.
- W4386606009 cites W2975605747 @default.
- W4386606009 cites W2981521201 @default.
- W4386606009 cites W2999771324 @default.
- W4386606009 cites W3006558781 @default.
- W4386606009 cites W3006586009 @default.
- W4386606009 cites W3008957287 @default.
- W4386606009 cites W3011481749 @default.
- W4386606009 cites W3013347515 @default.
- W4386606009 cites W3031994575 @default.
- W4386606009 cites W3040071259 @default.
- W4386606009 cites W3045897752 @default.
- W4386606009 cites W3047106569 @default.
- W4386606009 cites W3084415647 @default.
- W4386606009 cites W3093420565 @default.
- W4386606009 cites W3093764876 @default.
- W4386606009 cites W3111923637 @default.
- W4386606009 cites W3128494146 @default.
- W4386606009 cites W3128646645 @default.
- W4386606009 cites W3130224122 @default.
- W4386606009 cites W3130724250 @default.
- W4386606009 cites W3134553072 @default.
- W4386606009 cites W3135442043 @default.
- W4386606009 cites W3138059369 @default.
- W4386606009 cites W3139760916 @default.
- W4386606009 cites W3139883958 @default.
- W4386606009 cites W3157859847 @default.
- W4386606009 cites W3159930939 @default.
- W4386606009 cites W3160519118 @default.
- W4386606009 cites W3164754201 @default.
- W4386606009 cites W3165092845 @default.
- W4386606009 cites W3177008359 @default.
- W4386606009 cites W3206043227 @default.
- W4386606009 cites W3211488171 @default.
- W4386606009 cites W4200470336 @default.
- W4386606009 cites W4206839818 @default.
- W4386606009 cites W4211168195 @default.
- W4386606009 cites W4211260961 @default.
- W4386606009 cites W4282978269 @default.
- W4386606009 cites W4290466964 @default.
- W4386606009 cites W4296345592 @default.
- W4386606009 cites W4311970733 @default.
- W4386606009 doi "https://doi.org/10.2147/ijgm.s428580" @default.
- W4386606009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37720173" @default.
- W4386606009 hasPublicationYear "2023" @default.
- W4386606009 type Work @default.
- W4386606009 citedByCount "0" @default.
- W4386606009 crossrefType "journal-article" @default.
- W4386606009 hasAuthorship W4386606009A5005149399 @default.
- W4386606009 hasAuthorship W4386606009A5023632317 @default.
- W4386606009 hasAuthorship W4386606009A5037795734 @default.
- W4386606009 hasAuthorship W4386606009A5062758299 @default.
- W4386606009 hasAuthorship W4386606009A5081743397 @default.
- W4386606009 hasBestOaLocation W43866060091 @default.
- W4386606009 hasConcept C104317684 @default.
- W4386606009 hasConcept C121608353 @default.
- W4386606009 hasConcept C126322002 @default.
- W4386606009 hasConcept C143998085 @default.