Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386606574> ?p ?o ?g. }
- W4386606574 abstract "The tick-borne multisystemic infection caused by Borrelia burgdorferi sensu lato , Lyme borreliosis, or Lyme disease, occurring in temperate regions of the northern hemisphere, continues to spread geographically with the expanding tick population. Despite the rising perceived risk of infection in the population, the clinical diagnosis of Borrelia infection is not always obvious and the most important laboratory test, antibody detection, has limited accuracy in diagnosing active disease. According to international guidelines, the primary serology test, which has a high sensitivity-low specificity, should, be verified using a high specificity confirmation test to improve the specificity. However, this enhancement in specificity comes at the cost of lower sensitivity. This two-step procedure is often omitted in everyday clinical practice. An optimal primary test would be one where no secondary tests for confirmation would be necessary. In the present study, the performance of a novel assay for quantitating IgG1-subclass antibodies to Borrelia C6-peptide was compared to a commercial reference assay of total IgG and IgM antibodies to Borrelia C6-peptide in the setting of a high endemic area for borreliosis. A derivation study on a retrospective clinical material was performed to compare the performance parameters and assess the discriminatory properties of the assays, followed by a prospective validation study. The IgG1-antibody assay achieved comparable summary performance parameters to those of the reference assay. The sensitivity was almost 100% while the specificity was about 50%. In a high-endemic setting, characterized by high background seropositivity of about 50% and disease prevalence of approximately 10%, antibody tests are unable to rule-in active Borrelia infection. The rule-out assessment of the methods revealed that of 1000 patients, 7 – 54 with negative results based on the reference method could have an active Borrelia infection. Such uncertainty was not found for the index test and may help improve the risk classification of patients." @default.
- W4386606574 created "2023-09-12" @default.
- W4386606574 creator A5000787845 @default.
- W4386606574 creator A5011581472 @default.
- W4386606574 creator A5031363562 @default.
- W4386606574 creator A5032060319 @default.
- W4386606574 creator A5035511086 @default.
- W4386606574 creator A5084276982 @default.
- W4386606574 date "2023-09-11" @default.
- W4386606574 modified "2023-09-29" @default.
- W4386606574 title "Diagnostic probability classification in suspected borreliosis by a novel Borrelia C6-peptide IgG1- subclass antibody test" @default.
- W4386606574 cites W1548096328 @default.
- W4386606574 cites W1568084954 @default.
- W4386606574 cites W1593075812 @default.
- W4386606574 cites W1905802871 @default.
- W4386606574 cites W1925274372 @default.
- W4386606574 cites W1932761272 @default.
- W4386606574 cites W1993977065 @default.
- W4386606574 cites W2001373300 @default.
- W4386606574 cites W2035273924 @default.
- W4386606574 cites W2051681038 @default.
- W4386606574 cites W2053139562 @default.
- W4386606574 cites W2067747382 @default.
- W4386606574 cites W2085134195 @default.
- W4386606574 cites W2089403185 @default.
- W4386606574 cites W2090671888 @default.
- W4386606574 cites W2096766244 @default.
- W4386606574 cites W2098112686 @default.
- W4386606574 cites W2118763814 @default.
- W4386606574 cites W2128616785 @default.
- W4386606574 cites W2309534723 @default.
- W4386606574 cites W2413347629 @default.
- W4386606574 cites W2790036875 @default.
- W4386606574 cites W2802485424 @default.
- W4386606574 cites W2968236234 @default.
- W4386606574 cites W3003481921 @default.
- W4386606574 cites W3004357378 @default.
- W4386606574 cites W3016031851 @default.
- W4386606574 cites W3164413118 @default.
- W4386606574 cites W4210462952 @default.
- W4386606574 cites W4210982538 @default.
- W4386606574 cites W4211152344 @default.
- W4386606574 cites W4220687576 @default.
- W4386606574 cites W4232462786 @default.
- W4386606574 cites W4239494812 @default.
- W4386606574 cites W4297476907 @default.
- W4386606574 doi "https://doi.org/10.3389/fcimb.2023.1108115" @default.
- W4386606574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37753485" @default.
- W4386606574 hasPublicationYear "2023" @default.
- W4386606574 type Work @default.
- W4386606574 citedByCount "0" @default.
- W4386606574 crossrefType "journal-article" @default.
- W4386606574 hasAuthorship W4386606574A5000787845 @default.
- W4386606574 hasAuthorship W4386606574A5011581472 @default.
- W4386606574 hasAuthorship W4386606574A5031363562 @default.
- W4386606574 hasAuthorship W4386606574A5032060319 @default.
- W4386606574 hasAuthorship W4386606574A5035511086 @default.
- W4386606574 hasAuthorship W4386606574A5084276982 @default.
- W4386606574 hasBestOaLocation W43866065741 @default.
- W4386606574 hasConcept C159047783 @default.
- W4386606574 hasConcept C159654299 @default.
- W4386606574 hasConcept C203014093 @default.
- W4386606574 hasConcept C2776194381 @default.
- W4386606574 hasConcept C2777553296 @default.
- W4386606574 hasConcept C2779159148 @default.
- W4386606574 hasConcept C2780508971 @default.
- W4386606574 hasConcept C2908647359 @default.
- W4386606574 hasConcept C45189115 @default.
- W4386606574 hasConcept C71924100 @default.
- W4386606574 hasConcept C86803240 @default.
- W4386606574 hasConcept C99454951 @default.
- W4386606574 hasConceptScore W4386606574C159047783 @default.
- W4386606574 hasConceptScore W4386606574C159654299 @default.
- W4386606574 hasConceptScore W4386606574C203014093 @default.
- W4386606574 hasConceptScore W4386606574C2776194381 @default.
- W4386606574 hasConceptScore W4386606574C2777553296 @default.
- W4386606574 hasConceptScore W4386606574C2779159148 @default.
- W4386606574 hasConceptScore W4386606574C2780508971 @default.
- W4386606574 hasConceptScore W4386606574C2908647359 @default.
- W4386606574 hasConceptScore W4386606574C45189115 @default.
- W4386606574 hasConceptScore W4386606574C71924100 @default.
- W4386606574 hasConceptScore W4386606574C86803240 @default.
- W4386606574 hasConceptScore W4386606574C99454951 @default.
- W4386606574 hasLocation W43866065741 @default.
- W4386606574 hasLocation W43866065742 @default.
- W4386606574 hasOpenAccess W4386606574 @default.
- W4386606574 hasPrimaryLocation W43866065741 @default.
- W4386606574 hasRelatedWork W1419558638 @default.
- W4386606574 hasRelatedWork W1978761622 @default.
- W4386606574 hasRelatedWork W2166333863 @default.
- W4386606574 hasRelatedWork W2187858570 @default.
- W4386606574 hasRelatedWork W2344776289 @default.
- W4386606574 hasRelatedWork W2417648762 @default.
- W4386606574 hasRelatedWork W2779289971 @default.
- W4386606574 hasRelatedWork W3143981561 @default.
- W4386606574 hasRelatedWork W3190603120 @default.
- W4386606574 hasRelatedWork W39666760 @default.
- W4386606574 hasVolume "13" @default.
- W4386606574 isParatext "false" @default.
- W4386606574 isRetracted "false" @default.