Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386607218> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4386607218 abstract "Abstract To explore potential metabolomics biomarkers in predicting post-herpetic neuralgia (PHN) induced by herpes zoster (HZ). A total of 90 eligible patients were prospectively enrolled and assigned into an acute pain (ACP) group and a PHN group. Serum samples were collected before clinical intervention to perform metabolomics profiling analyses using gas chromatography mass spectrometry (GC–MS). Key metabolites were identified using partial least squares discriminant analysis (PLS-DA). A binary logistic regression was used to build a combined biomarker model to predict PHN from ACP. The discriminating efficiency of the combined biomarker model was investigated and validated by internal validation. Six metabolites were identified as the key metabolites related to PHN. All these metabolites ( N -Acetyl-5-hydroxytryptaMine, glucose, dehydroascorbic acid, isopropyl-beta- d -thiogalactopyranoside, 1,5-anhydro- d -sorbitol, and glutamic acid) were found elevated in the PHN group. Pathway analyses showed that glucose-alanine cycle, tryptophan metabolism, tyrosine metabolism, lactose degradation, malate-aspartate shuttle were top five metabolic pathways evolved in PHN. The AUC was 0.85 (95% CI 0.76–0.93) for the combined biomarker model, and was 0.91 (95% CI 0.84–1.00) for the internal validation data set to predict PHN. Metabolomics analyses of key metabolites could be used to predict PHN induced by HZ." @default.
- W4386607218 created "2023-09-12" @default.
- W4386607218 creator A5018304214 @default.
- W4386607218 creator A5022708781 @default.
- W4386607218 creator A5036712663 @default.
- W4386607218 creator A5055920402 @default.
- W4386607218 creator A5072984777 @default.
- W4386607218 creator A5076042276 @default.
- W4386607218 date "2023-09-11" @default.
- W4386607218 modified "2023-09-26" @default.
- W4386607218 title "Metabolomics profiling in predicting of post-herpetic neuralgia induced by varicella zoster" @default.
- W4386607218 cites W1966384426 @default.
- W4386607218 cites W1994242014 @default.
- W4386607218 cites W1996252736 @default.
- W4386607218 cites W2002297789 @default.
- W4386607218 cites W2018478972 @default.
- W4386607218 cites W2035593608 @default.
- W4386607218 cites W2040947756 @default.
- W4386607218 cites W2086045680 @default.
- W4386607218 cites W2091183373 @default.
- W4386607218 cites W2123912930 @default.
- W4386607218 cites W2583613500 @default.
- W4386607218 cites W2770900079 @default.
- W4386607218 cites W2788457950 @default.
- W4386607218 cites W2901887035 @default.
- W4386607218 cites W2997936982 @default.
- W4386607218 cites W3027815239 @default.
- W4386607218 cites W3081508393 @default.
- W4386607218 cites W3122229354 @default.
- W4386607218 cites W3143174477 @default.
- W4386607218 cites W3164311002 @default.
- W4386607218 cites W3199620845 @default.
- W4386607218 cites W4206778766 @default.
- W4386607218 cites W4210617213 @default.
- W4386607218 doi "https://doi.org/10.1038/s41598-023-42363-z" @default.
- W4386607218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37697028" @default.
- W4386607218 hasPublicationYear "2023" @default.
- W4386607218 type Work @default.
- W4386607218 citedByCount "0" @default.
- W4386607218 crossrefType "journal-article" @default.
- W4386607218 hasAuthorship W4386607218A5018304214 @default.
- W4386607218 hasAuthorship W4386607218A5022708781 @default.
- W4386607218 hasAuthorship W4386607218A5036712663 @default.
- W4386607218 hasAuthorship W4386607218A5055920402 @default.
- W4386607218 hasAuthorship W4386607218A5072984777 @default.
- W4386607218 hasAuthorship W4386607218A5076042276 @default.
- W4386607218 hasBestOaLocation W43866072181 @default.
- W4386607218 hasConcept C126322002 @default.
- W4386607218 hasConcept C135870905 @default.
- W4386607218 hasConcept C185592680 @default.
- W4386607218 hasConcept C203014093 @default.
- W4386607218 hasConcept C21565614 @default.
- W4386607218 hasConcept C2522874641 @default.
- W4386607218 hasConcept C2776159415 @default.
- W4386607218 hasConcept C2781197716 @default.
- W4386607218 hasConcept C43617362 @default.
- W4386607218 hasConcept C55493867 @default.
- W4386607218 hasConcept C71924100 @default.
- W4386607218 hasConcept C98274493 @default.
- W4386607218 hasConceptScore W4386607218C126322002 @default.
- W4386607218 hasConceptScore W4386607218C135870905 @default.
- W4386607218 hasConceptScore W4386607218C185592680 @default.
- W4386607218 hasConceptScore W4386607218C203014093 @default.
- W4386607218 hasConceptScore W4386607218C21565614 @default.
- W4386607218 hasConceptScore W4386607218C2522874641 @default.
- W4386607218 hasConceptScore W4386607218C2776159415 @default.
- W4386607218 hasConceptScore W4386607218C2781197716 @default.
- W4386607218 hasConceptScore W4386607218C43617362 @default.
- W4386607218 hasConceptScore W4386607218C55493867 @default.
- W4386607218 hasConceptScore W4386607218C71924100 @default.
- W4386607218 hasConceptScore W4386607218C98274493 @default.
- W4386607218 hasIssue "1" @default.
- W4386607218 hasLocation W43866072181 @default.
- W4386607218 hasLocation W43866072182 @default.
- W4386607218 hasOpenAccess W4386607218 @default.
- W4386607218 hasPrimaryLocation W43866072181 @default.
- W4386607218 hasRelatedWork W1539434924 @default.
- W4386607218 hasRelatedWork W1996644818 @default.
- W4386607218 hasRelatedWork W2005430136 @default.
- W4386607218 hasRelatedWork W2306509029 @default.
- W4386607218 hasRelatedWork W2431325196 @default.
- W4386607218 hasRelatedWork W2748952813 @default.
- W4386607218 hasRelatedWork W2765395567 @default.
- W4386607218 hasRelatedWork W2899084033 @default.
- W4386607218 hasRelatedWork W3166411857 @default.
- W4386607218 hasRelatedWork W4322503085 @default.
- W4386607218 hasVolume "13" @default.
- W4386607218 isParatext "false" @default.
- W4386607218 isRetracted "false" @default.
- W4386607218 workType "article" @default.