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• W4386616371 abstract "Although the role of thyroid hormones in functional and anatomical closure of patent ductus arteriosus (PDA) is well known, their effects on the medical or surgical closure of PDA in newborns remain unclear. This study aimed to assess the correlation between thyroid function tests and PDA closure through medical or surgical interventions in newborns.This retrospective study was conducted on 65 newborns diagnosed with hemodynamically significant PDA (hs-PDA), with a premature rate of 81.5% (n=53). The subjects were divided into two groups according to the nature of the ductal closure as medically responsive MR-PDA or surgically treated ST-PDA. The groups were compared in terms of thyroid hormone levels and other clinical parameters.Thirty-three (51%) of all 65 patients had PDA and responded to medical treatment. Gestational week, birth weight, and mode of delivery were similar between the medical and surgical treatment groups (p>0.05). Free thyroxine levels were significantly lower in the MR-PDA group than in the ST-PDA group (p=0.01).Because hs-PDA is associated with increased morbidity and mortality in the neonatal period, especially in premature infants, we hypothesize that thyroid hormone levels may play a role in the closure of hs-PDA.Tiroid hormonlarının, patent duktus arteriozusun (PDA) fonksiyonel ve anatomik kapanmasında etkinliği bilinmekle beraber medikal ve/veya cerrahi olarak kapanan PDA’lı yenidoğan bebeklerdeki etkinliği bilinmemektedir. Bu çalışmada yenidoğan bebeklerde tiroid fonksiyon testleri ile medikal ve cerrahi olarak kapatılan PDA arasındaki ilişkiyi değerlendirmeyi amaçladık.Bu çalışma retrospektif bir çalışma olup, 65 hemodinamik anlamlı PDA’lı (hs-PDA) yenidoğan çalışmaya alınmıştır. Çalışmaya alınan yenidoğanların 53’ünü (%81,5) preterm bebekler oluşturmaktaydı. Olgular duktal kapanma tiplerine göre medikal yanıtlı “MR-PDA” veya cerrahi tedavi gereken “ST-PDA” olarak iki gruba ayrıldı. Medikal tedaviye duyarlı ve dirençli PDA’sı olan yenidoğanlarda, tiroid hormon düzeyleri ile bu düzeylere etki eden faktörler karşılaştırıldı.Çalışmaya alınan hastaların 33’ünü (%51) medikal tedaviye duyarlı PDA’sı olan yenidoğan bebekler oluşturmaktaydı. PDA’sı medikal ve cerrahi tedavi ile kapatılan gruplar arasında gestasyon haftası, doğum ağırlığı ve doğum şekli benzer idi (p>0,05). Medikal tedaviye duyarlı PDA’lı grubun serbest tiroksin düzeyleri, medikal tedaviye dirençli gruba göre anlamlı olarak düşüktü (p=0,01).hs-PDA, yenidoğan döneminde, özellikle de prematüre bebeklerde artmış morbidite ve mortalite ile ilişkili olduğundan, tiroid hormon düzeylerinin hs-PDA kapanmasında etkili olabileceğini düşünmekteyiz." @default.
• W4386616371 created "2023-09-12" @default.
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• W4386616371 date "2023-09-28" @default.
• W4386616371 modified "2023-10-10" @default.
• W4386616371 title "The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns" @default.
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• W4386616371 doi "https://doi.org/10.4274/mmj.galenos.2023.25853" @default.
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