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• W4386616810 abstract "This study aimed to compare the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values in patients with euthyroid Hashimoto's thyroiditis (HT) with healthy control subjects.This was a single-center, retrospective, cross-sectional study conducted on obese patients aged 18 years and over. The medical records of patients who presented with complaints of being overweight at the obesity clinic between April 2017 and May 2019 were examined. Patients and healthy individuals were included in the study consecutively until the sample sizes reached saturation. Patients with diabetes, cardiovascular disease, chronic inflammatory disease, and malignancy were excluded from the study. The patients' anthropometric measurements, smoking status, blood examination, and thyroid ultrasounds were evaluated. The difference in means between the groups was calculated using the Mann-Whitney U test.The study included 179 participants, consisting of 93 patients and 86 healthy controls. The mean age was 46.6±14.1 years, with most females (91.6%). Although the NLR and PLR values in patients were higher than those in the control group, the difference did not reach statistical significance (p=0.427 and p=0.089, respectively). Furthermore, no significant difference was observed in NLR (p=0.191) and PLR (p=0.668) values between levothyroxine-treated and untreated patients. Correlation analysis revealed weak positive associations between C-reactive protein and thyroid peroxidase antibodies (p<0.05), neutrophils (p<0.01), platelets (p<0.01), and NLR (p<0.05).The findings of this study suggest that NLR and PLR may not serve as effective indicators of systemic inflammation in patients with euthyroid HT, nor do they adequately assess the impact of levothyroxine usage on systemic inflammation.Bu çalışmanın amacı, ötiroid Hashimoto tiroiditi (HT) hastalarında nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranı (PLO) değerlerinin sağlıklı kontrol grubuyla karşılaştırılmasıdır.Bu tek merkezli, retrospektif, kesitsel çalışma 18 yaş ve üzeri obez hastalar ile gerçekleştirildi. Nisan 2017 ile Mayıs 2019 tarihleri arasında obezite kliniğine kilo fazlalığı şikayeti ile başvuran hastaların tıbbi kayıtları tarandı. Örneklem boyutları doygunluğa ulaşana kadar ötiroid HT ve kontrol grubundan kişiler ardışık olarak çalışmaya dahil edilmeye devam edildi. Diyabet, koroner arter hastalığı, kronik enflamatuvar hastalığı ve malignite öyküsü olan hastalar çalışmaya alınmadı. Hastaların yaş, cinsiyet, boy, kilo, sigara içme durumu, laboratuvar ve tiroid ultrasonografi sonuçları değerlendirildi. Değişkenlerin ortalamalarının gruplar arasındaki farklılığı, Mann-Whitney U testi kullanılarak hesaplandı.Çalışmaya, 93 ötiroid HT ve 86 sağlıklı kontrol olmak üzere toplam 179 kişi dahil edildi. Ortalama yaş 46,6±14,1 yıl olarak bulundu ve kadınlar çoğunluktaydı (%91,6). HT olan hastalarda NLO ve PLO değeri kontrol grubuna göre daha yüksek olsa da iki grup arasındaki fark istatistiksel anlama ulaşmadı (sırası ile p=0,427, p=0,089). Ayrıca, levotiroksin tedavisi alan ve almayan hastalar arasında da NLO (p=0,191) ve PLO (p=0,668) değerlerinde anlamlı bir fark gözlenmedi. Korelasyon analizi, C-reaktif protein ile tiroid peroksidaz antikorlar (p<0,05), nötrofiller (p<0,01), trombositler (p<0,01) ve NLO (p<0,05) arasında zayıf pozitif ilişkileri ortaya çıkardı.Çalışmanın bulguları, NLO ve PLO’nun ötiroid HT hastalarında sistemik enflamasyonun etkili göstergeleri olmadığını ve levotiroksin kullanımının sistemik enflamasyon üzerindeki etkisini yeterince değerlendiremediklerini düşündürmektedir." @default.
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• W4386616810 date "2023-09-28" @default.
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• W4386616810 title "Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto’s Thyroiditis" @default.
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• W4386616810 doi "https://doi.org/10.4274/mmj.galenos.2023.41882" @default.
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