FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386618659> ?p ?o ?g. }

• W4386618659 abstract "Minimally invasive approaches to cancer treatment are intended to decrease surgical morbidity and thus reduce the negative impact on the quality of life for patients. This thesis focuses on evaluating the minimally invasive approach to the treatment of early-stage cervical cancer. In the first part of this thesis, we examined various aspects of sentinel lymph node (SLN) mapping, a minimally invasive technique to assess whether there is metastasis to the lymph nodes. The concept of SLN mapping is based on the existence of an orderly and predictable pattern of lymphatic drainage with a first lymph node, i.e. the sentinel lymph node, to which tumour cells spread from a primary tumour. Sentinel lymph nodes can be mapped by injecting tracers around the tumour. Recently, the fluorescent tracer indocyanine green (ICG) has emerged as an alternative to the conventional combined approach of a radiotracer and blue dye. The presumed advantages of ICG, that is, being cheaper, non-radioactive, and logistically more attractive than the combined approach, are only valuable if its detection rate proves to be at least non-inferior. We showed that the effectiveness of ICG needs to be properly investigated before we can safely omit the currently used tracers. This finding led to setting up a prospective study comparing the SLN detection of the combined approach of a radiotracer and blue dye with ICG. Once excised, SLNs are processed according to the pathological ultrastaging protocol, consisting of serial sectioning and immunohistochemical staining. Ultrastaging enhances the detection of low volume disease, defined as isolated tumour cells or micrometastasis, which is rarely found with conventional sectioning and staining. We showed that the use of immunohistochemical staining is of added value but at high cost. Therefore, it is important to research more selective use of this technique and, in the future, the use of artificial intelligence. In the second part of this thesis, we investigated the learning curve of robot-assisted surgery, an innovative and minimally invasive surgical technique. As surgical performance tends to improve with experience, learning curve effects seem unavoidable when adopting new and complex surgical technologies. We showed that the introduction of robot-assisted surgery can be accompanied by a learning phase in which the outcomes are inferior to the more experienced phase. By using a risk-adjusted cumulative sum (RA-CUSUM) analysis, we established the number of cases needed to ascertain surgical proficiency in terms of satisfying recurrence rates. Our findings also suggest that learning curve effects can be reduced by structured training. With this thesis, we aim to raise awareness of learning curve effects and the importance of structured learning curricula for robot-assisted surgery. The work in this thesis resulted in an evaluation of existing minimally invasive techniques applied in early-stage cervical cancer. The gained knowledge helps us to further improve the SLN mapping technique and robot-assisted surgery while continuously investigating each step. Ultimately, when adopting new minimally invasive approaches in the field of early-stage cervical cancer, the key issue is to minimise harm for our patients while maintaining oncological safety." @default.
• W4386618659 created "2023-09-12" @default.
• W4386618659 creator A5079787263 @default.
• W4386618659 date "2023-09-11" @default.
• W4386618659 modified "2023-10-18" @default.
• W4386618659 title "Evaluating sentinel lymph node mapping and robot-assisted surgery in early-stage cervical cancer" @default.
• W4386618659 doi "https://doi.org/10.33540/729" @default.
• W4386618659 hasPublicationYear "2023" @default.
• W4386618659 type Work @default.
• W4386618659 citedByCount "0" @default.
• W4386618659 crossrefType "dissertation" @default.
• W4386618659 hasAuthorship W4386618659A5079787263 @default.
• W4386618659 hasConcept C121608353 @default.
• W4386618659 hasConcept C126322002 @default.
• W4386618659 hasConcept C126838900 @default.
• W4386618659 hasConcept C141071460 @default.
• W4386618659 hasConcept C142724271 @default.
• W4386618659 hasConcept C146357865 @default.
• W4386618659 hasConcept C151730666 @default.
• W4386618659 hasConcept C179671157 @default.
• W4386618659 hasConcept C181152851 @default.
• W4386618659 hasConcept C2777793825 @default.
• W4386618659 hasConcept C2779013556 @default.
• W4386618659 hasConcept C2779720271 @default.
• W4386618659 hasConcept C2780212769 @default.
• W4386618659 hasConcept C2780849966 @default.
• W4386618659 hasConcept C2781065829 @default.
• W4386618659 hasConcept C530470458 @default.
• W4386618659 hasConcept C71924100 @default.
• W4386618659 hasConcept C86803240 @default.
• W4386618659 hasConceptScore W4386618659C121608353 @default.
• W4386618659 hasConceptScore W4386618659C126322002 @default.
• W4386618659 hasConceptScore W4386618659C126838900 @default.
• W4386618659 hasConceptScore W4386618659C141071460 @default.
• W4386618659 hasConceptScore W4386618659C142724271 @default.
• W4386618659 hasConceptScore W4386618659C146357865 @default.
• W4386618659 hasConceptScore W4386618659C151730666 @default.
• W4386618659 hasConceptScore W4386618659C179671157 @default.
• W4386618659 hasConceptScore W4386618659C181152851 @default.
• W4386618659 hasConceptScore W4386618659C2777793825 @default.
• W4386618659 hasConceptScore W4386618659C2779013556 @default.
• W4386618659 hasConceptScore W4386618659C2779720271 @default.
• W4386618659 hasConceptScore W4386618659C2780212769 @default.
• W4386618659 hasConceptScore W4386618659C2780849966 @default.
• W4386618659 hasConceptScore W4386618659C2781065829 @default.
• W4386618659 hasConceptScore W4386618659C530470458 @default.
• W4386618659 hasConceptScore W4386618659C71924100 @default.
• W4386618659 hasConceptScore W4386618659C86803240 @default.
• W4386618659 hasLocation W43866186591 @default.
• W4386618659 hasOpenAccess W4386618659 @default.
• W4386618659 hasPrimaryLocation W43866186591 @default.
• W4386618659 hasRelatedWork W2083126214 @default.
• W4386618659 hasRelatedWork W2325813839 @default.
• W4386618659 hasRelatedWork W2342283132 @default.
• W4386618659 hasRelatedWork W2463411296 @default.
• W4386618659 hasRelatedWork W2530361638 @default.
• W4386618659 hasRelatedWork W2531745859 @default.
• W4386618659 hasRelatedWork W4248223122 @default.
• W4386618659 hasRelatedWork W4285032483 @default.
• W4386618659 hasRelatedWork W4385492325 @default.
• W4386618659 hasRelatedWork W3023587326 @default.
• W4386618659 isParatext "false" @default.
• W4386618659 isRetracted "false" @default.
• W4386618659 workType "dissertation" @default.