Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386623897> ?p ?o ?g. }
- W4386623897 endingPage "475" @default.
- W4386623897 startingPage "468" @default.
- W4386623897 abstract "While working for the United States Department of Agriculture on the North Dakota Agricultural College campus in Fargo, North Dakota, in the 1940s and 1950s, Harold H. Flor formulated the genetic principles for coevolving plant host-pathogen interactions that govern disease resistance or susceptibility. His ‘gene-for-gene’ legacy runs deep in modern plant pathology and continues to inform molecular models of plant immune recognition and signaling. In this review, we discuss recent biochemical insights to plant immunity conferred by nucleotide-binding domain/leucine-rich-repeat (NLR) receptors, which are major gene-for-gene resistance determinants in nature and cultivated crops. Structural and biochemical analyses of pathogen-activated NLR oligomers (resistosomes) reveal how different NLR subtypes converge in various ways on calcium (Ca 2+ ) signaling to promote pathogen immunity and host cell death. Especially striking is the identification of nucleotide-based signals generated enzymatically by plant toll-interleukin 1 receptor (TIR) domain NLRs. These small molecules are part of an emerging family of TIR-produced cyclic and noncyclic nucleotide signals that steer immune and cell-death responses in bacteria, mammals, and plants. A combined genetic, molecular, and biochemical understanding of plant NLR activation and signaling provides exciting new opportunities for combatting diseases in crops. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license ." @default.
- W4386623897 created "2023-09-13" @default.
- W4386623897 creator A5013706725 @default.
- W4386623897 creator A5029053030 @default.
- W4386623897 creator A5066266709 @default.
- W4386623897 date "2023-08-01" @default.
- W4386623897 modified "2023-09-30" @default.
- W4386623897 title "New Biochemical Principles for NLR Immunity in Plants" @default.
- W4386623897 cites W1626508217 @default.
- W4386623897 cites W1988178270 @default.
- W4386623897 cites W1988197452 @default.
- W4386623897 cites W1989416547 @default.
- W4386623897 cites W2010174706 @default.
- W4386623897 cites W2010854320 @default.
- W4386623897 cites W2016032876 @default.
- W4386623897 cites W2052874989 @default.
- W4386623897 cites W2095443145 @default.
- W4386623897 cites W2102564339 @default.
- W4386623897 cites W2110768663 @default.
- W4386623897 cites W2115185894 @default.
- W4386623897 cites W2118569143 @default.
- W4386623897 cites W2136931477 @default.
- W4386623897 cites W2155611044 @default.
- W4386623897 cites W2168120687 @default.
- W4386623897 cites W2183675419 @default.
- W4386623897 cites W2402195444 @default.
- W4386623897 cites W2558438718 @default.
- W4386623897 cites W2584708022 @default.
- W4386623897 cites W2602599682 @default.
- W4386623897 cites W2736049245 @default.
- W4386623897 cites W2768654995 @default.
- W4386623897 cites W2775877430 @default.
- W4386623897 cites W2785101149 @default.
- W4386623897 cites W2896861545 @default.
- W4386623897 cites W2899395786 @default.
- W4386623897 cites W2906030297 @default.
- W4386623897 cites W2906522235 @default.
- W4386623897 cites W2914409053 @default.
- W4386623897 cites W2924139971 @default.
- W4386623897 cites W2927068340 @default.
- W4386623897 cites W2956495423 @default.
- W4386623897 cites W2969268623 @default.
- W4386623897 cites W2969680514 @default.
- W4386623897 cites W2980498147 @default.
- W4386623897 cites W2990575322 @default.
- W4386623897 cites W2999148493 @default.
- W4386623897 cites W3024956527 @default.
- W4386623897 cites W3034751020 @default.
- W4386623897 cites W3035232037 @default.
- W4386623897 cites W3044405565 @default.
- W4386623897 cites W3049197258 @default.
- W4386623897 cites W3085875657 @default.
- W4386623897 cites W3102496954 @default.
- W4386623897 cites W3106552706 @default.
- W4386623897 cites W3106866272 @default.
- W4386623897 cites W3112440234 @default.
- W4386623897 cites W3135339687 @default.
- W4386623897 cites W3135815505 @default.
- W4386623897 cites W3135840948 @default.
- W4386623897 cites W3153527204 @default.
- W4386623897 cites W3158869528 @default.
- W4386623897 cites W3163855438 @default.
- W4386623897 cites W3164833455 @default.
- W4386623897 cites W3167479618 @default.
- W4386623897 cites W3171151332 @default.
- W4386623897 cites W3182953644 @default.
- W4386623897 cites W3187271770 @default.
- W4386623897 cites W3188300656 @default.
- W4386623897 cites W3193739344 @default.
- W4386623897 cites W3196504904 @default.
- W4386623897 cites W3201336326 @default.
- W4386623897 cites W3206070115 @default.
- W4386623897 cites W3207001544 @default.
- W4386623897 cites W3216692711 @default.
- W4386623897 cites W4200166081 @default.
- W4386623897 cites W4200168383 @default.
- W4386623897 cites W4205504353 @default.
- W4386623897 cites W4210280679 @default.
- W4386623897 cites W4210617542 @default.
- W4386623897 cites W4210962045 @default.
- W4386623897 cites W4220726385 @default.
- W4386623897 cites W4220890417 @default.
- W4386623897 cites W4220905794 @default.
- W4386623897 cites W4280553143 @default.
- W4386623897 cites W4280558795 @default.
- W4386623897 cites W4283394644 @default.
- W4386623897 cites W4283654771 @default.
- W4386623897 cites W4283720836 @default.
- W4386623897 cites W4284678419 @default.
- W4386623897 cites W4284701778 @default.
- W4386623897 cites W4291020693 @default.
- W4386623897 cites W4293298428 @default.
- W4386623897 cites W4294074096 @default.
- W4386623897 cites W4295066571 @default.
- W4386623897 cites W4296793778 @default.
- W4386623897 cites W4296802427 @default.
- W4386623897 cites W4297183739 @default.
- W4386623897 cites W4297243353 @default.