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• W4386624153 endingPage "26" @default.
• W4386624153 startingPage "1" @default.
• W4386624153 abstract "The occurrence of micro(nano)plastics into various environmental and biological settings influences their physicochemical and toxic behavior. Simulated body fluids are appropriate media in which to understand the degradation, stability, and interaction with other substances of any materials into the human body. When the particles enter the human body via inhalation which is one of the avenues for micro(nano)plastics, they first come into contact with the lung lining fluid under neutral conditions and then are phagocytosed under acidic conditions to be removed. Therefore, it is important to examine the physicochemical transformation and toxicity characteristics after interaction with phagolysosomal simulant fluid. Here we focused on exploring how the physicochemical differences (e.g., surface chemistry, elemental distribution, surface charge) of micro(nano)plastics under pH 4.5 phagolysosome conditions impact cytotoxicity and the oxidative characteristics of lung epithelia cells. The cytotoxicity of lung epithelia cells to those treated with phagolysosomal simulant fluid and non-treated micro(nano)plastics were tested by various viability indicators including CCK-8, MTT and LDH. Furthermore, the cytotoxicity background was examined through the oxidative processes (e.g., reactive oxygen species, antioxidant, superoxide dismutase, catalase, and reduced glutathione). The results showed that all tested surface physicochemical characteristics were significantly influenced by the phagolysosome conditions. The staged responses were observed with the treatment duration, and significant changes were calculated in carbonyl, carbon-nitrogen, and sulfonyl groups. Moreover, the negativity of the zeta potentials declined between exposure of 2 h to 40 h and then increased at 80 h compared to control owing to the chemical functional groups and elemental distribution of the plastic particles. The tested viability indicators showed that the micro(nano)plastics treated with phagolysosomal simulant fluid were cytotoxic to the lung epithelia cells compared to non-treated micro(nano)plastics, and superoxide dismutase was the dominant enzyme triggering cytotoxicity due to the particle degradation and instability." @default.
• W4386624153 created "2023-09-13" @default.
• W4386624153 creator A5003616625 @default.
• W4386624153 creator A5008220670 @default.
• W4386624153 creator A5044653169 @default.
• W4386624153 creator A5060637251 @default.
• W4386624153 date "2023-09-11" @default.
• W4386624153 modified "2023-09-26" @default.
• W4386624153 title "Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells" @default.
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