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- W4386629402 abstract "The kynurenine pathway (KP) and the endocannabinoid system (ECS) are known to be deregulated in depression and obesity; however, it has been recognized that acute physical exercise has an important modulating role inducing changes in the mobilization of their respective metabolites -endocannabinoids (eCB) and kynurenines (KYN)- which overlap at some points, acting as im-portant antidepressant, anti-nociceptive, anti-inflammatory, and antioxidant biomarkers. There-fore, the aim of this review is to analyze and discuss some studies performed recently to investigate the potential interactions between both systems, particularly, those related with exercise-derived endocannabinoidome and kynurenine mechanisms and to elucidate how, the prescription of physical exercise could represent a new approach for the clinical manage of these two conditions." @default.
- W4386629402 created "2023-09-13" @default.
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- W4386629402 date "2023-09-12" @default.
- W4386629402 modified "2023-09-29" @default.
- W4386629402 title "Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies against Obesity and Depression Symptoms" @default.
- W4386629402 doi "https://doi.org/10.20944/preprints202309.0734.v1" @default.
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