Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386629514> ?p ?o ?g. }
- W4386629514 endingPage "167038" @default.
- W4386629514 startingPage "167038" @default.
- W4386629514 abstract "Ultrafine particles (UFP) with a diameter of ≤0.1 μm, are contributors to ambient air pollution and derived mainly from traffic emissions, yet their health effects remain poorly characterized. The olfactory mucosa (OM) is located at the rooftop of the nasal cavity and directly exposed to both the environment and the brain. Mounting evidence suggests that pollutant particles affect the brain through the olfactory tract, however, the exact cellular mechanisms of how the OM responds to air pollutants remain poorly known. Here we show that the responses of primary human OM cells are altered upon exposure to UFPs and that different fuels and engines elicit different adverse effects. We used UFPs collected from exhausts of a heavy-duty-engine run with renewable diesel (A0) and fossil diesel (A20), and from a modern diesel vehicle run with renewable diesel (Euro6) and compared their health effects on the OM cells by assessing cellular processes on the functional and transcriptomic levels. Quantification revealed all samples as UFPs with the majority of particles being ≤0.1 μm by an aerodynamic diameter. Exposure to A0 and A20 induced substantial alterations in processes associated with inflammatory response, xenobiotic metabolism, olfactory signaling, and epithelial integrity. Euro6 caused only negligible changes, demonstrating the efficacy of aftertreatment devices. Furthermore, when compared to A20, A0 elicited less pronounced effects on OM cells, suggesting renewable diesel induces less adverse effects in OM cells. Prior studies and these results suggest that PAHs may disturb the inflammatory process and xenobiotic metabolism in the OM and that UFPs might mediate harmful effects on the brain through the olfactory route. This study provides important information on the adverse effects of UFPs in a human-based in vitro model, therefore providing new insight to form the basis for mitigation and preventive actions against the possible toxicological impairments caused by UFP exposure." @default.
- W4386629514 created "2023-09-13" @default.
- W4386629514 creator A5002057785 @default.
- W4386629514 creator A5005897448 @default.
- W4386629514 creator A5008663744 @default.
- W4386629514 creator A5025395834 @default.
- W4386629514 creator A5028805572 @default.
- W4386629514 creator A5031765078 @default.
- W4386629514 creator A5032035270 @default.
- W4386629514 creator A5043036513 @default.
- W4386629514 creator A5043310758 @default.
- W4386629514 creator A5045729764 @default.
- W4386629514 creator A5052022265 @default.
- W4386629514 creator A5053982660 @default.
- W4386629514 creator A5054962878 @default.
- W4386629514 creator A5064459714 @default.
- W4386629514 creator A5066425280 @default.
- W4386629514 creator A5067207213 @default.
- W4386629514 creator A5070932322 @default.
- W4386629514 creator A5073172339 @default.
- W4386629514 creator A5075230061 @default.
- W4386629514 creator A5077394618 @default.
- W4386629514 creator A5085739668 @default.
- W4386629514 creator A5085937659 @default.
- W4386629514 creator A5092764430 @default.
- W4386629514 date "2023-12-01" @default.
- W4386629514 modified "2023-10-15" @default.
- W4386629514 title "Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment" @default.
- W4386629514 cites W1822174311 @default.
- W4386629514 cites W1967382412 @default.
- W4386629514 cites W1970727134 @default.
- W4386629514 cites W1973668473 @default.
- W4386629514 cites W1993207284 @default.
- W4386629514 cites W2001433854 @default.
- W4386629514 cites W2004196333 @default.
- W4386629514 cites W2022591842 @default.
- W4386629514 cites W2028425269 @default.
- W4386629514 cites W2034813267 @default.
- W4386629514 cites W2048979310 @default.
- W4386629514 cites W2057265291 @default.
- W4386629514 cites W2071178772 @default.
- W4386629514 cites W2077729621 @default.
- W4386629514 cites W2099184612 @default.
- W4386629514 cites W2100256027 @default.
- W4386629514 cites W2125957493 @default.
- W4386629514 cites W2130656719 @default.
- W4386629514 cites W2131271579 @default.
- W4386629514 cites W2138207763 @default.
- W4386629514 cites W2140930579 @default.
- W4386629514 cites W2162143298 @default.
- W4386629514 cites W2169456326 @default.
- W4386629514 cites W2171726938 @default.
- W4386629514 cites W2179438025 @default.
- W4386629514 cites W2323736786 @default.
- W4386629514 cites W2353599515 @default.
- W4386629514 cites W2404437421 @default.
- W4386629514 cites W2418629764 @default.
- W4386629514 cites W2464915778 @default.
- W4386629514 cites W2511433639 @default.
- W4386629514 cites W2525408110 @default.
- W4386629514 cites W2527670917 @default.
- W4386629514 cites W2547512433 @default.
- W4386629514 cites W2556234553 @default.
- W4386629514 cites W2607111630 @default.
- W4386629514 cites W2769403314 @default.
- W4386629514 cites W2771410465 @default.
- W4386629514 cites W2790043170 @default.
- W4386629514 cites W2794072512 @default.
- W4386629514 cites W2946946072 @default.
- W4386629514 cites W2956134726 @default.
- W4386629514 cites W2971739096 @default.
- W4386629514 cites W2974156775 @default.
- W4386629514 cites W2974641390 @default.
- W4386629514 cites W2979673336 @default.
- W4386629514 cites W2990806292 @default.
- W4386629514 cites W2992764976 @default.
- W4386629514 cites W2997741444 @default.
- W4386629514 cites W2999121700 @default.
- W4386629514 cites W3006474680 @default.
- W4386629514 cites W3010038216 @default.
- W4386629514 cites W3011054918 @default.
- W4386629514 cites W3011625613 @default.
- W4386629514 cites W3012311085 @default.
- W4386629514 cites W3022961853 @default.
- W4386629514 cites W3032034527 @default.
- W4386629514 cites W3034793831 @default.
- W4386629514 cites W3035710790 @default.
- W4386629514 cites W3080428097 @default.
- W4386629514 cites W3081442061 @default.
- W4386629514 cites W3091680348 @default.
- W4386629514 cites W3108332913 @default.
- W4386629514 cites W3111270892 @default.
- W4386629514 cites W3121058838 @default.
- W4386629514 cites W3125398380 @default.
- W4386629514 cites W3125891893 @default.
- W4386629514 cites W3126630017 @default.
- W4386629514 cites W3147537054 @default.
- W4386629514 cites W3165786240 @default.