FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386636307> ?p ?o ?g. }

• W4386636307 abstract "Abstract Background Klebsiella pneumoniae is a significant healthcare-associated pathogen. We investigated the antimicrobial interaction pattern between zinc sulfate and antibiotics against K. pneumoniae biofilm on the phenotypic and genotypic levels. Methods Determining the minimum biofilm inhibitory concentrations and the transcriptomic profile of K. pneumoniae biofilm formation genes post-treatment were carried out to evaluate the effect on the phenotypic and genotypic levels, respectively. Results Zinc enhanced the antibiofilm potentials of cephalosporins, aminoglycosides, and ertapenem, whereas it antagonizes the effectiveness of fluoroquinolones and meropenem on the phenotypic level. On the molecular level, zinc enhanced the anti-biofilm efficacies of cephalosporins (cefotaxime, ceftriaxone, ceftazidime, cefpirome, and cefepime) via down-regulating the expression of biofilm-related genes by 18-, 38-, 5-, 77- and 2-folds, respectively. Zinc in combination with aminoglycosides (kanamycin, gentamicin, and amikacin) reduced the expression of biofilm-related genes by 40-, 2602- and 20-folds, respectively, and by 2-folds in combination with ertapenem. However, a reduction in the down-regulatory potentials of fluoroquinolones was recorded following combination with zinc by 2-, 2-, 15- and 14-folds, respectively, and an up-regulation in the expression levels of the tested genes by 2-folds in the case of zinc/meropenem combination. Conclusions Results revealed variable interaction patterns between different antibiotics in combination with zinc. Current findings also shed light on the antibiofilm potentials of zinc/antibiotics combinations especially when combining zinc with fluoroquinolones or meropenem to avoid their antagonistic effects." @default.
• W4386636307 created "2023-09-13" @default.
• W4386636307 creator A5049020987 @default.
• W4386636307 creator A5058555582 @default.
• W4386636307 creator A5063025932 @default.
• W4386636307 date "2023-09-12" @default.
• W4386636307 modified "2023-10-04" @default.
• W4386636307 title "Modulating the transcriptomic profile of multidrug-resistant Klebsiella pneumoniae biofilm formation by antibiotics in combination with zinc sulfate" @default.
• W4386636307 cites W1992035959 @default.
• W4386636307 cites W1996442931 @default.
• W4386636307 cites W2004738756 @default.
• W4386636307 cites W2024070582 @default.
• W4386636307 cites W2024132074 @default.
• W4386636307 cites W2057455680 @default.
• W4386636307 cites W2078735798 @default.
• W4386636307 cites W2101095533 @default.
• W4386636307 cites W2107600014 @default.
• W4386636307 cites W2108429684 @default.
• W4386636307 cites W2114570899 @default.
• W4386636307 cites W2138073171 @default.
• W4386636307 cites W2165389260 @default.
• W4386636307 cites W2168421163 @default.
• W4386636307 cites W2179722594 @default.
• W4386636307 cites W2540937557 @default.
• W4386636307 cites W2560276740 @default.
• W4386636307 cites W2565977564 @default.
• W4386636307 cites W2737969967 @default.
• W4386636307 cites W2898728315 @default.
• W4386636307 cites W2937075150 @default.
• W4386636307 cites W2942546077 @default.
• W4386636307 cites W2995046922 @default.
• W4386636307 cites W3008933953 @default.
• W4386636307 cites W3022731996 @default.
• W4386636307 cites W3099329710 @default.
• W4386636307 cites W4210334674 @default.
• W4386636307 cites W4280610801 @default.
• W4386636307 cites W4283689749 @default.
• W4386636307 cites W4297172943 @default.
• W4386636307 doi "https://doi.org/10.1186/s12941-023-00634-7" @default.
• W4386636307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37700331" @default.
• W4386636307 hasPublicationYear "2023" @default.
• W4386636307 type Work @default.
• W4386636307 citedByCount "0" @default.
• W4386636307 crossrefType "journal-article" @default.
• W4386636307 hasAuthorship W4386636307A5049020987 @default.
• W4386636307 hasAuthorship W4386636307A5058555582 @default.
• W4386636307 hasAuthorship W4386636307A5063025932 @default.
• W4386636307 hasBestOaLocation W43866363071 @default.
• W4386636307 hasConcept C104317684 @default.
• W4386636307 hasConcept C185592680 @default.
• W4386636307 hasConcept C2776520383 @default.
• W4386636307 hasConcept C2776933286 @default.
• W4386636307 hasConcept C2777050379 @default.
• W4386636307 hasConcept C2777058267 @default.
• W4386636307 hasConcept C2777427914 @default.
• W4386636307 hasConcept C2777457247 @default.
• W4386636307 hasConcept C2778368673 @default.
• W4386636307 hasConcept C2778719061 @default.
• W4386636307 hasConcept C2779375183 @default.
• W4386636307 hasConcept C2779489039 @default.
• W4386636307 hasConcept C2779631663 @default.
• W4386636307 hasConcept C501593827 @default.
• W4386636307 hasConcept C523546767 @default.
• W4386636307 hasConcept C54355233 @default.
• W4386636307 hasConcept C547475151 @default.
• W4386636307 hasConcept C55493867 @default.
• W4386636307 hasConcept C58123911 @default.
• W4386636307 hasConcept C64778159 @default.
• W4386636307 hasConcept C86803240 @default.
• W4386636307 hasConcept C89423630 @default.
• W4386636307 hasConcept C94665300 @default.
• W4386636307 hasConceptScore W4386636307C104317684 @default.
• W4386636307 hasConceptScore W4386636307C185592680 @default.
• W4386636307 hasConceptScore W4386636307C2776520383 @default.
• W4386636307 hasConceptScore W4386636307C2776933286 @default.
• W4386636307 hasConceptScore W4386636307C2777050379 @default.
• W4386636307 hasConceptScore W4386636307C2777058267 @default.
• W4386636307 hasConceptScore W4386636307C2777427914 @default.
• W4386636307 hasConceptScore W4386636307C2777457247 @default.
• W4386636307 hasConceptScore W4386636307C2778368673 @default.
• W4386636307 hasConceptScore W4386636307C2778719061 @default.
• W4386636307 hasConceptScore W4386636307C2779375183 @default.
• W4386636307 hasConceptScore W4386636307C2779489039 @default.
• W4386636307 hasConceptScore W4386636307C2779631663 @default.
• W4386636307 hasConceptScore W4386636307C501593827 @default.
• W4386636307 hasConceptScore W4386636307C523546767 @default.
• W4386636307 hasConceptScore W4386636307C54355233 @default.
• W4386636307 hasConceptScore W4386636307C547475151 @default.
• W4386636307 hasConceptScore W4386636307C55493867 @default.
• W4386636307 hasConceptScore W4386636307C58123911 @default.
• W4386636307 hasConceptScore W4386636307C64778159 @default.
• W4386636307 hasConceptScore W4386636307C86803240 @default.
• W4386636307 hasConceptScore W4386636307C89423630 @default.
• W4386636307 hasConceptScore W4386636307C94665300 @default.
• W4386636307 hasIssue "1" @default.
• W4386636307 hasLocation W43866363071 @default.
• W4386636307 hasLocation W43866363072 @default.
• W4386636307 hasOpenAccess W4386636307 @default.
• W4386636307 hasPrimaryLocation W43866363071 @default.
• W4386636307 hasRelatedWork W1969107923 @default.

• next