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- W4386638324 abstract "Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence by switching its forms from yeasts to hyphae and becomes the major pathogenic agent for oral candidiasis. However, the overuse of current clinical antifungals and lack of new types of drugs highlight the challenges in the antifungal treatments because of the drug resistance and side effects. Anti-virulence strategy is proved as a practical way to develop new types of anti-infective drugs. Here, seven artemisinins, including artemisinin, dihydroartemisinin, artemisinic acid, dihydroartemisinic acid, artesunate, artemether and arteether, were employed to target at the hyphal development, the most important virulence factor of C. albicans. Artemisinins failed to affect the growth, but significantly inhibited the hyphal development of C. albicans, including the clinical azole resistant isolates, and reduced their damage to oral epithelial cells, while arteether showed the strongest activities. The transcriptome suggested that arteether could affect the energy metabolism of C. albicans. Seven artemisinins were then proved to significantly inhibit the productions of ATP and cAMP, while reduced the hyphal inhibition on RAS1 overexpression strain indicating that artemisinins regulated the Ras1-cAMP-Efg1 pathway to inhibit the hyphal development. Importantly, arteether significantly inhibited the fungal burden and infections with no systemic toxicity in the murine oropharyngeal candidiasis models in vivo caused by both fluconazole sensitive and resistant strains. Our results for the first time indicated that artemisinins can be potential antifungal compounds against C. albicans infections by targeting at its hyphal development." @default.
- W4386638324 created "2023-09-13" @default.
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- W4386638324 date "2023-09-12" @default.
- W4386638324 modified "2023-10-10" @default.
- W4386638324 title "Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development" @default.
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- W4386638324 cites W1993122323 @default.
- W4386638324 cites W1993501149 @default.
- W4386638324 cites W2006156671 @default.
- W4386638324 cites W2011758386 @default.
- W4386638324 cites W2033721665 @default.
- W4386638324 cites W2042565484 @default.
- W4386638324 cites W2050394160 @default.
- W4386638324 cites W2058268415 @default.
- W4386638324 cites W2075824039 @default.
- W4386638324 cites W2077088073 @default.
- W4386638324 cites W2083001268 @default.
- W4386638324 cites W2102429461 @default.
- W4386638324 cites W2107794472 @default.
- W4386638324 cites W2142554739 @default.
- W4386638324 cites W2143820120 @default.
- W4386638324 cites W2163110564 @default.
- W4386638324 cites W2329943654 @default.
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- W4386638324 cites W2794593110 @default.
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- W4386638324 cites W2895137000 @default.
- W4386638324 cites W2896091232 @default.
- W4386638324 cites W2896513955 @default.
- W4386638324 cites W2901109605 @default.
- W4386638324 cites W2922239993 @default.
- W4386638324 cites W2929371282 @default.
- W4386638324 cites W2944959421 @default.
- W4386638324 cites W2950010168 @default.
- W4386638324 cites W3010280345 @default.
- W4386638324 cites W3016029167 @default.
- W4386638324 cites W3026958586 @default.
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- W4386638324 cites W3093683101 @default.
- W4386638324 cites W3108001659 @default.
- W4386638324 cites W3109995454 @default.
- W4386638324 cites W3124481512 @default.
- W4386638324 cites W3130638170 @default.
- W4386638324 cites W3173467099 @default.
- W4386638324 cites W3176616296 @default.
- W4386638324 cites W3177820775 @default.
- W4386638324 cites W3202074216 @default.
- W4386638324 cites W3205559506 @default.
- W4386638324 cites W4200437538 @default.
- W4386638324 cites W4206438577 @default.
- W4386638324 cites W4210250306 @default.
- W4386638324 cites W4214877855 @default.
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- W4386638324 cites W4220972968 @default.
- W4386638324 cites W4224024832 @default.
- W4386638324 cites W4283727121 @default.
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- W4386638324 cites W4365137016 @default.
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- W4386638324 cites W4377101764 @default.
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- W4386638324 doi "https://doi.org/10.1038/s41368-023-00245-0" @default.
- W4386638324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37699886" @default.
- W4386638324 hasPublicationYear "2023" @default.
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