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- W4386640418 abstract "Reports on chronic endometritis (CE) suggest that microbial pathogens in endometrium cause endometrial inflammation and infertility1,2. Lactobacillus has been described as biorregulatory in this context, improving outcomes when detected in higher levels than pathogens3. However, the existence of a core endometrial microbiome, its precise composition and its impact on the endometrial inflammatory status are still unclear4,5. In this study, we analysed the expression of IL-4, and the presence of 18 microbial CE pathogens and 4 Lactobacillus species in endometrial samples of 456 patients in their WOI. A subset of these samples was also analysed by flow cytometry to quantify endometrial B and T cells. Finally, clinical outcomes (clinical pregnancy, CP; live birth, LB) of euploid single embryo transfers (esETs) were compared in relation to the endometrial microbiota profile. Patients without microbial detection had significantly higher CP (64.2% vs 50.8%, p=0.046) and LB rates (52.9% vs 37.2%, p=0.03) than patients with microorganisms. They also had lower amounts of B (0.76% vs 1.5%) and T cells (16.98% vs 28.1%), specifically CD8+ cytotoxic T cells (28.4% vs 41.1%), suggesting that the presence of endometrial microorganisms causes endometrial inflammation and lowers fertility rates. Pathogen-only patients had significantly lower CP rates than patients without microbial detection (41.2% vs 64.2%, p=0.038). Lactobacillus dominance in pathogen-positive patients improved outcomes compared to pathogen-dominated patients (CP 56.7% vs 42.2%; LB 41.7% vs 31%). This was associated to significantly higher amounts of endometrial IL-4 in Lactobacillus-dominated patients (85% higher), suggesting that Lactobacillus acts as modulator of the endometrial inflammatory response." @default.
- W4386640418 created "2023-09-13" @default.
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- W4386640418 date "2023-09-01" @default.
- W4386640418 modified "2023-09-30" @default.
- W4386640418 title "The composition of the endometrial microbiota alters the endometrial immune environment and significantly impacts clinical outcomes of assisted reproduction treatments" @default.
- W4386640418 doi "https://doi.org/10.1016/j.jri.2023.104033" @default.
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