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- W4386640790 abstract "Oocyte donation (OD) pregnancies are related to a higher degree of fetal-maternal HLA mismatching. We hypothesize that in OD pregnancies with high HLA dissimilarity, the immune response at the fetal-maternal interface (the decidua) is divergent to maintain a healthy state. Children and mothers after OD pregnancy were typed for HLA-A, -B, C, -DRB1, and -DQB1. Based on fetal-maternal HLA mismatching, samples were selected for a semi-allogeneic group (≤5 HLA mismatches, n=4) and a fully allogeneic group (>5 mismatches, n=4). Imaging mass cytometry (IMC) with a 42-antibody panel was applied on decidua tissues of these 8 samples. Single-cell masks were created using cell segmentation. Myeloid cells (65%) and T cells (10%) represented the most abundant immune cell populations at the decidua. Twelve phenotypically distinct subclusters were identified within the myeloid cell lineage. IMC also gives possibility for investigating the microenvironment of each cell to study cell-cell interactions. The fully allogeneic group showed a higher frequency of myeloid cells in the microenvironment of T cells than the semi-allogeneic OD group (p<0.05). Most notably, a higher extent of interaction between CD163+HLA-DR+ myeloid cells and CD4+ T cells was observed in the fully allogeneic group compared to the semi-allogeneic OD group (p<0.05). Our results show the phenotypic diversity of decidual myeloid cells and their prominent frequency in uncomplicated OD pregnancies. By interacting with T helper cells, decidual myeloid cells might exert immune regulatory effects to compensate for the higher fetal-maternal HLA mismatch load in OD pregnancies." @default.
- W4386640790 created "2023-09-13" @default.
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- W4386640790 date "2023-09-01" @default.
- W4386640790 modified "2023-10-14" @default.
- W4386640790 title "Spatial composition of decidual immune cells in oocyte donation pregnancies in relation to fetal-maternal HLA incompatibility" @default.
- W4386640790 doi "https://doi.org/10.1016/j.jri.2023.104046" @default.
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