Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386645565> ?p ?o ?g. }
- W4386645565 endingPage "1913" @default.
- W4386645565 startingPage "1913" @default.
- W4386645565 abstract "Hepatitis B virus (HBV) chronically infects millions of people worldwide, which underscores the importance of discovering and designing novel anti-HBV therapeutics to complement current treatment strategies. An underexploited but attractive therapeutic target is ε, a cis-acting regulatory stem-loop RNA situated within the HBV pregenomic RNA (pgRNA). The binding of ε to the viral polymerase protein (P) is pivotal, as it triggers the packaging of pgRNA and P, as well as the reverse transcription of the viral genome. Consequently, small molecules capable of disrupting this interaction hold the potential to inhibit the early stages of HBV replication. The rational design of such ligands necessitates high-resolution structural information for the ε–P complex or its individual components. While these data are currently unavailable for P, our recent structural elucidation of ε through solution nuclear magnetic resonance spectroscopy marks a significant advancement in this area. In this review, we provide a brief overview of HBV replication and some of the therapeutic strategies to combat chronic HBV infection. These descriptions are intended to contextualize our recent experimental efforts to characterize ε and identify ε-targeting ligands, with the ultimate goal of developing novel anti-HBV therapeutics." @default.
- W4386645565 created "2023-09-13" @default.
- W4386645565 creator A5030233282 @default.
- W4386645565 creator A5031942940 @default.
- W4386645565 creator A5048482851 @default.
- W4386645565 creator A5069490995 @default.
- W4386645565 creator A5077177874 @default.
- W4386645565 creator A5092854216 @default.
- W4386645565 date "2023-09-12" @default.
- W4386645565 modified "2023-10-05" @default.
- W4386645565 title "Hepatitis B Virus Epsilon (ε) RNA Element: Dynamic Regulator of Viral Replication and Attractive Therapeutic Target" @default.
- W4386645565 cites W1187022970 @default.
- W4386645565 cites W1193311108 @default.
- W4386645565 cites W1502882236 @default.
- W4386645565 cites W1510252058 @default.
- W4386645565 cites W1511455589 @default.
- W4386645565 cites W1559776411 @default.
- W4386645565 cites W1568443657 @default.
- W4386645565 cites W1585835 @default.
- W4386645565 cites W1585930597 @default.
- W4386645565 cites W1598074241 @default.
- W4386645565 cites W1603287226 @default.
- W4386645565 cites W1631507265 @default.
- W4386645565 cites W1757990252 @default.
- W4386645565 cites W1815984339 @default.
- W4386645565 cites W1844576826 @default.
- W4386645565 cites W1894278338 @default.
- W4386645565 cites W1924733150 @default.
- W4386645565 cites W1963623444 @default.
- W4386645565 cites W1965197241 @default.
- W4386645565 cites W1967159039 @default.
- W4386645565 cites W1969776963 @default.
- W4386645565 cites W1972992218 @default.
- W4386645565 cites W1977173978 @default.
- W4386645565 cites W1978314081 @default.
- W4386645565 cites W1979730660 @default.
- W4386645565 cites W1984472078 @default.
- W4386645565 cites W1985577568 @default.
- W4386645565 cites W1985821700 @default.
- W4386645565 cites W1985860298 @default.
- W4386645565 cites W1985891965 @default.
- W4386645565 cites W1986388698 @default.
- W4386645565 cites W1988615815 @default.
- W4386645565 cites W1989831346 @default.
- W4386645565 cites W1990137109 @default.
- W4386645565 cites W1990487307 @default.
- W4386645565 cites W1992232854 @default.
- W4386645565 cites W1992296745 @default.
- W4386645565 cites W1992985034 @default.
- W4386645565 cites W1994361603 @default.
- W4386645565 cites W1997047331 @default.
- W4386645565 cites W1997270466 @default.
- W4386645565 cites W2000336618 @default.
- W4386645565 cites W2002969023 @default.
- W4386645565 cites W2006509109 @default.
- W4386645565 cites W2007278972 @default.
- W4386645565 cites W2008517556 @default.
- W4386645565 cites W2011239129 @default.
- W4386645565 cites W2011555137 @default.
- W4386645565 cites W2011557623 @default.
- W4386645565 cites W2015763479 @default.
- W4386645565 cites W2016032631 @default.
- W4386645565 cites W2017568077 @default.
- W4386645565 cites W2017857849 @default.
- W4386645565 cites W2019732485 @default.
- W4386645565 cites W2021865492 @default.
- W4386645565 cites W2024988675 @default.
- W4386645565 cites W2026382336 @default.
- W4386645565 cites W2027482274 @default.
- W4386645565 cites W2027543203 @default.
- W4386645565 cites W2027555120 @default.
- W4386645565 cites W2028207573 @default.
- W4386645565 cites W2029180341 @default.
- W4386645565 cites W2031802185 @default.
- W4386645565 cites W2034247538 @default.
- W4386645565 cites W2035920453 @default.
- W4386645565 cites W2038723467 @default.
- W4386645565 cites W2040195110 @default.
- W4386645565 cites W2040562731 @default.
- W4386645565 cites W2040872421 @default.
- W4386645565 cites W2042396550 @default.
- W4386645565 cites W2042881722 @default.
- W4386645565 cites W2044951291 @default.
- W4386645565 cites W2045108297 @default.
- W4386645565 cites W2046182783 @default.
- W4386645565 cites W2047232371 @default.
- W4386645565 cites W2047443816 @default.
- W4386645565 cites W2051100798 @default.
- W4386645565 cites W2051173965 @default.
- W4386645565 cites W2052700689 @default.
- W4386645565 cites W2054200297 @default.
- W4386645565 cites W2054227142 @default.
- W4386645565 cites W2059560167 @default.
- W4386645565 cites W2061239746 @default.
- W4386645565 cites W2062192098 @default.
- W4386645565 cites W2064823659 @default.
- W4386645565 cites W2069336380 @default.
- W4386645565 cites W2070025124 @default.