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• W4386645827 endingPage "042004" @default.
• W4386645827 startingPage "042004" @default.
• W4386645827 abstract "Microfluidic organs and organoids-on-a-chip models of human gastrointestinal systems have been established to recreate adequate microenvironments to study physiology and pathophysiology. In the effort to find more emulating systems and less costly models for drugs screening or fundamental studies, gastrointestinal system organoids-on-a-chip have arisen as promising pre-clinicalin vitromodel. This progress has been built on the latest developments of several technologies such as bioprinting, microfluidics, and organoid research. In this review, we will focus on healthy and disease models of: human microbiome-on-a-chip and its rising correlation with gastro pathophysiology; stomach-on-a-chip; liver-on-a-chip; pancreas-on-a-chip; inflammation models, small intestine, colon and colorectal cancer organoids-on-a-chip and multi-organoids-on-a-chip. The current developments related to the design, ability to hold one or more 'organs' and its challenges, microfluidic features, cell sources and whether they are used to test drugs are overviewed herein. Importantly, their contribution in terms of drug development and eminent clinical translation in precision medicine field, Food and Drug Administration approved models, and the impact of organoid-on-chip technology in terms of pharmaceutical research and development costs are also discussed by the authors." @default.
• W4386645827 created "2023-09-13" @default.
• W4386645827 creator A5002487860 @default.
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• W4386645827 creator A5056935928 @default.
• W4386645827 date "2023-09-22" @default.
• W4386645827 modified "2023-10-14" @default.
• W4386645827 title "Gastrointestinal organs and organoids-on-a-chip: advances and translation into the clinics" @default.
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• W4386645827 doi "https://doi.org/10.1088/1758-5090/acf8fb" @default.
• W4386645827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37699408" @default.
• W4386645827 hasPublicationYear "2023" @default.
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