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- W4386647680 abstract "The primary motor cortex (M1) and the dorsal striatum play a critical role in motor learning and the retention of learned behaviors. Motor representations of corticostriatal ensembles emerge during motor learning. In the coordinated reorganization of M1 and the dorsal striatum for motor learning, layer 5a (L5a), which connects M1 to the ipsi- and contra-lateral dorsal striatum, should be a key layer. Although M1 L5a neurons represent movement-related activity in the late stage of learning, it is unclear whether the activity is retained as a memory engram. Here, using Tlx3-Cre male transgenic mice, we conducted two-photon calcium imaging of striatum-projecting L5a intratelencephalic (IT) neurons in forelimb M1 during late sessions of a self-initiated lever-pull task, and in sessions after 6 days of non-training following the late sessions. We found that trained male animals exhibited stable motor performance before and after the non-training days. At the same time, we found that M1 L5a IT neurons strongly represented the well-learned forelimb movement, but not uninstructed orofacial movements. A subset of M1 L5a IT neurons consistently coded the well-learned forelimb movement before and after the non-training days. Inactivation of M1 IT neurons after learning impaired task performance when the lever was made heavier or when the target range of the pull distance was narrowed. These results suggest that a subset of M1 L5a IT neurons continuously represent skilled movement after learning and serve to fine-tune the kinematics of well-learned movement. Significance Statement Motor memory persists even when it is not used for a while. Intratelencephalic neurons in layer 5a (L5a IT neurons) of the primary motor cortex (M1) gradually come to represent skilled forelimb movements during motor learning. However, it remains to be determined whether these changes persist over a long period and how these neurons contribute to skilled movements. Here, we show that a subset of M1 L5a IT neurons retain information for skilled forelimb movements even after non-training days. Furthermore, suppressing the activity of these neurons during skilled forelimb movements impaired behavioral stability and adaptability. Our results suggest the importance of M1 L5a IT neurons for tuning skilled forelimb movements over a long period." @default.
- W4386647680 created "2023-09-13" @default.
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- W4386647680 date "2023-09-12" @default.
- W4386647680 modified "2023-10-18" @default.
- W4386647680 title "Layer 5 intratelencephalic neurons in the motor cortex stably encode skilled movement" @default.
- W4386647680 doi "https://doi.org/10.1523/jneurosci.0428-23.2023" @default.
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