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- W4386649968 endingPage "105246" @default.
- W4386649968 startingPage "105246" @default.
- W4386649968 abstract "Long viewed as an intermediary in protein translation, there is a growing awareness that tRNAs are capable of myriad other biological functions linked to human health and disease. These emerging roles could be tapped to leverage tRNAs as diagnostic biomarkers, therapeutic targets, or even as novel medicines. Furthermore, the growing array of tRNA-derived fragments, which modulate an increasingly broad spectrum of cellular pathways, is expanding this opportunity. Together, these molecules offer drug developers the chance to modulate the impact of mutations and to alter cell homeostasis. Moreover, because a single therapeutic tRNA can facilitate readthrough of a genetic mutation shared across multiple genes, such medicines afford the opportunity to define patient populations not based on their clinical presentation or mutated gene but rather on the mutation itself. This approach could potentially transform the treatment of patients with rare and ultrarare diseases. In this review, we explore the diverse biology of tRNA and its fragments, examining the past and present challenges to provide a comprehensive understanding of the molecules and their therapeutic potential." @default.
- W4386649968 created "2023-09-13" @default.
- W4386649968 creator A5030673677 @default.
- W4386649968 creator A5082585604 @default.
- W4386649968 date "2023-10-01" @default.
- W4386649968 modified "2023-10-15" @default.
- W4386649968 title "Ushering in the era of tRNA medicines" @default.
- W4386649968 cites W1832399013 @default.
- W4386649968 cites W1910229720 @default.
- W4386649968 cites W1985069389 @default.
- W4386649968 cites W2002959910 @default.
- W4386649968 cites W2008149648 @default.
- W4386649968 cites W2013321787 @default.
- W4386649968 cites W2016206195 @default.
- W4386649968 cites W2024412145 @default.
- W4386649968 cites W2033184553 @default.
- W4386649968 cites W2055639102 @default.
- W4386649968 cites W2057014596 @default.
- W4386649968 cites W2062594227 @default.
- W4386649968 cites W2067022150 @default.
- W4386649968 cites W2068694787 @default.
- W4386649968 cites W2076772609 @default.
- W4386649968 cites W2078223063 @default.
- W4386649968 cites W2088025779 @default.
- W4386649968 cites W2093956979 @default.
- W4386649968 cites W2100966665 @default.
- W4386649968 cites W2103413006 @default.
- W4386649968 cites W2105837504 @default.
- W4386649968 cites W2106039274 @default.
- W4386649968 cites W2109925162 @default.
- W4386649968 cites W2112243735 @default.
- W4386649968 cites W2114147818 @default.
- W4386649968 cites W2126330038 @default.
- W4386649968 cites W2128312594 @default.
- W4386649968 cites W2131759299 @default.
- W4386649968 cites W2136861527 @default.
- W4386649968 cites W2142152307 @default.
- W4386649968 cites W2148431781 @default.
- W4386649968 cites W2155765704 @default.
- W4386649968 cites W2164256634 @default.
- W4386649968 cites W2167133210 @default.
- W4386649968 cites W2171329251 @default.
- W4386649968 cites W2210574172 @default.
- W4386649968 cites W2218013351 @default.
- W4386649968 cites W2234931430 @default.
- W4386649968 cites W2320312730 @default.
- W4386649968 cites W2333295355 @default.
- W4386649968 cites W2417123930 @default.
- W4386649968 cites W2418276263 @default.
- W4386649968 cites W2466333954 @default.
- W4386649968 cites W2494760636 @default.
- W4386649968 cites W2495238549 @default.
- W4386649968 cites W2516993644 @default.
- W4386649968 cites W2560828227 @default.
- W4386649968 cites W2570396264 @default.
- W4386649968 cites W2597396396 @default.
- W4386649968 cites W2614145559 @default.
- W4386649968 cites W2624373429 @default.
- W4386649968 cites W2738598315 @default.
- W4386649968 cites W2755658631 @default.
- W4386649968 cites W2762868004 @default.
- W4386649968 cites W2775233218 @default.
- W4386649968 cites W2792897553 @default.
- W4386649968 cites W2795813366 @default.
- W4386649968 cites W2801179771 @default.
- W4386649968 cites W2802049840 @default.
- W4386649968 cites W2808496870 @default.
- W4386649968 cites W2883988883 @default.
- W4386649968 cites W2887650798 @default.
- W4386649968 cites W2890219238 @default.
- W4386649968 cites W2897690672 @default.
- W4386649968 cites W2914598464 @default.
- W4386649968 cites W2940525406 @default.
- W4386649968 cites W2940931641 @default.
- W4386649968 cites W2945463715 @default.
- W4386649968 cites W2949980705 @default.
- W4386649968 cites W2965220844 @default.
- W4386649968 cites W2970783812 @default.
- W4386649968 cites W2982293539 @default.
- W4386649968 cites W2990003274 @default.
- W4386649968 cites W2990482336 @default.
- W4386649968 cites W2991022372 @default.
- W4386649968 cites W2991201071 @default.
- W4386649968 cites W2997516127 @default.
- W4386649968 cites W3002722315 @default.
- W4386649968 cites W3008698633 @default.
- W4386649968 cites W3012588995 @default.
- W4386649968 cites W3020403418 @default.
- W4386649968 cites W3024300365 @default.
- W4386649968 cites W3037578051 @default.
- W4386649968 cites W3040197336 @default.
- W4386649968 cites W3042273632 @default.
- W4386649968 cites W3048999744 @default.
- W4386649968 cites W3063613132 @default.
- W4386649968 cites W3082382384 @default.
- W4386649968 cites W3083874241 @default.
- W4386649968 cites W3090029515 @default.
- W4386649968 cites W3107339771 @default.