FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386660782> ?p ?o ?g. }

• W4386660782 abstract "Abstract Background At present, it is worth noting that there is a lack of biomarker for the residual risk of thrombosis in patients underwent percutaneous coronary intervention (PCI). D-dimer is an important thrombus marker and widely used in clinical practice. Purpose We aim to investigate the correlation between D-dimer and the risk of stent thrombosis (ST) after PCI. Method This is a prospective, observational study of 10,724 patients who underwent PCI. The primary endpoint was ST, which was defined according to the Academic Research Consortium including definite, probable, and possible. Results Finally, 8565 patients were included in this study after excluding 2159 people with missing D-dimer data or lost to follow-up. After 2-year follow-up, there were 77 ST occurred. D-dimer levels were significantly higher in the ST group (0.33 [0.28, 0.56] μg/ml) than in the non-ST group (0.28 [0.20, 0.41] μg/ml) (P=0.001). Kaplan–Meier survival curve analysis showed that patients with high D-dimer levels had higher cumulative ST according to the median D-dimer level (0.28 μg/ml) in the total population, acute coronary syndrome (ACS) subgroup, and stable coronary artery disease (SCAD) subgroup, respectively. (log-rank test, all P&lt;0.001) (Figure 1). After multivariate-adjusted cox hazard analysis, high D-dimer levels (≥0.28 μg/ml) were significantly associated with ST in the total population (hazard ratio [HR]: 2.25, 95% confidence interval [CI]: 1.29–3.95, P=0.005) and ACS subgroup (HR: 2.13, 95% CI: 1.09–4.16, P=0.027); however, we did not find a statistically significant in the SCAD subgroup (HR: 2.56, 95% CI: 0.92–7.1, P=0.072). Conclusion In this real world and large sample data study, we reported for the first time that D-dimer was strong independent thrombosis biomarker in patient who underwent PCI. In the future, we may use D-dimer to guide individualized antithrombotic therapy after PCI. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): CAMS Innovation Fund for Medical Sciences; Young and middle-aged talents in the XPCC Science and Technology Project" @default.
• W4386660782 created "2023-09-13" @default.
• W4386660782 creator A5003019918 @default.
• W4386660782 creator A5004320397 @default.
• W4386660782 creator A5010475253 @default.
• W4386660782 creator A5023378337 @default.
• W4386660782 creator A5045349004 @default.
• W4386660782 creator A5052883326 @default.
• W4386660782 creator A5075782732 @default.
• W4386660782 date "2021-10-01" @default.
• W4386660782 modified "2023-09-29" @default.
• W4386660782 title "D-dimer as a potential novel thrombus biomarker for predict stent thrombosis in patients on dual antiplatelet therapy after percutaneous coronary intervention" @default.
• W4386660782 doi "https://doi.org/10.1093/eurheartj/ehab724.1281" @default.
• W4386660782 hasPublicationYear "2021" @default.
• W4386660782 type Work @default.
• W4386660782 citedByCount "0" @default.
• W4386660782 crossrefType "journal-article" @default.
• W4386660782 hasAuthorship W4386660782A5003019918 @default.
• W4386660782 hasAuthorship W4386660782A5004320397 @default.
• W4386660782 hasAuthorship W4386660782A5010475253 @default.
• W4386660782 hasAuthorship W4386660782A5023378337 @default.
• W4386660782 hasAuthorship W4386660782A5045349004 @default.
• W4386660782 hasAuthorship W4386660782A5052883326 @default.
• W4386660782 hasAuthorship W4386660782A5075782732 @default.
• W4386660782 hasBestOaLocation W43866607821 @default.
• W4386660782 hasConcept C126322002 @default.
• W4386660782 hasConcept C141071460 @default.
• W4386660782 hasConcept C164705383 @default.
• W4386660782 hasConcept C207103383 @default.
• W4386660782 hasConcept C2777698277 @default.
• W4386660782 hasConcept C2778213512 @default.
• W4386660782 hasConcept C2778583881 @default.
• W4386660782 hasConcept C2780400711 @default.
• W4386660782 hasConcept C2780868729 @default.
• W4386660782 hasConcept C2908647359 @default.
• W4386660782 hasConcept C44249647 @default.
• W4386660782 hasConcept C45393284 @default.
• W4386660782 hasConcept C500558357 @default.
• W4386660782 hasConcept C71924100 @default.
• W4386660782 hasConcept C99454951 @default.
• W4386660782 hasConceptScore W4386660782C126322002 @default.
• W4386660782 hasConceptScore W4386660782C141071460 @default.
• W4386660782 hasConceptScore W4386660782C164705383 @default.
• W4386660782 hasConceptScore W4386660782C207103383 @default.
• W4386660782 hasConceptScore W4386660782C2777698277 @default.
• W4386660782 hasConceptScore W4386660782C2778213512 @default.
• W4386660782 hasConceptScore W4386660782C2778583881 @default.
• W4386660782 hasConceptScore W4386660782C2780400711 @default.
• W4386660782 hasConceptScore W4386660782C2780868729 @default.
• W4386660782 hasConceptScore W4386660782C2908647359 @default.
• W4386660782 hasConceptScore W4386660782C44249647 @default.
• W4386660782 hasConceptScore W4386660782C45393284 @default.
• W4386660782 hasConceptScore W4386660782C500558357 @default.
• W4386660782 hasConceptScore W4386660782C71924100 @default.
• W4386660782 hasConceptScore W4386660782C99454951 @default.
• W4386660782 hasIssue "Supplement_1" @default.
• W4386660782 hasLocation W43866607821 @default.
• W4386660782 hasOpenAccess W4386660782 @default.
• W4386660782 hasPrimaryLocation W43866607821 @default.
• W4386660782 hasRelatedWork W1994690683 @default.
• W4386660782 hasRelatedWork W2079494746 @default.
• W4386660782 hasRelatedWork W2129387994 @default.
• W4386660782 hasRelatedWork W2145553842 @default.
• W4386660782 hasRelatedWork W2761804449 @default.
• W4386660782 hasRelatedWork W2762524193 @default.
• W4386660782 hasRelatedWork W2893320569 @default.
• W4386660782 hasRelatedWork W2905317511 @default.
• W4386660782 hasRelatedWork W2967328091 @default.
• W4386660782 hasRelatedWork W3206436045 @default.
• W4386660782 hasVolume "42" @default.
• W4386660782 isParatext "false" @default.
• W4386660782 isRetracted "false" @default.
• W4386660782 workType "article" @default.