FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386664037> ?p ?o ?g. }

• W4386664037 abstract "Research Article Egyptian Journal of Basic and Clinical PharmacologyVol. 11 (2021), Article ID 101511, 9 pages doi:10.32527/2021/101511 Amelioration of Cyclophosphamide-Induced Immunosuppression after Treatment with Polyherbal Formulation Extract Kabir Magaji Hamid1, Mohammed Haruna Yeldu2, Musa Ismail Abdullahi3, Nura Abubakar Kaoje1,4, Mansur Aliyu5*, Isah Sulaiman Yahaya6, and Abubakar Babangida Usman1. 1Department of Immunology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria. 2Department of Chemical Pathology, School of Medical Laboratory Sciences, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria. 3Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, P.M.B. 2346, Sokoto, Nigeria. 4Department of Health Services, Federal University Birnin Kebbi, Nigeria. 5Department of Medical Microbiology and Parasitology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University. P.M.B., 3011, Kano, Nigeria. 6Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Bayero University. P.M.B., 3011, Kano, Nigeria. Received 18 October 2020; Accepted 15 August 2021 Editor: Hany M. El-Bassossy Copyright © 2021 Kabir Magaji Hamid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract The study evaluated the therapeutic potential of aqueous extract of polyherbal formulation (PHF) in cyclophosphamide (CP)-induced immunosuppression in rats. A total of 20 Wistar albino rats, 5 per group, were used. The animals were grouped into four: Normal control received 10 ml/kg BW of normal saline orally for 28 days. Negative control received 10 mg/kg BW of CP subcutaneously for three days. Treatment control received 1500 mg/kg BW of PHF orally for 28 days. The experiment group received 10 mg/kg BW of CP subcutaneously for three days, followed by immediate oral administration of 1500 mg/kg BW of PHF for 28 days. The rats were primed and challenged with 0.1 ml normal saline containing 100 μg/kg BW of KLH for delayed-type hypersensitivity (DTH) response. DTH response was assessed via paw edema using a vernier caliper. Keyhole limpet Hemocyanin (KLH)-IgG Antibody level and serum cytokines (IFN-γ, IL-4, and IL-10) were measured using sandwich enzyme-linked immunosorbent assay (ELISA). Histology of lymphoid organs was examined and reported. There is a significant difference between experimental and control groups in DTH (p<0.001), and the experimental group shows an increase in KLH-IgG antibodies compared to normal control groups. In experimental group, serum IFN-γ (p = 0.002) and IL-4 (p = 0.001) significantly increase after PHF-treatment compared to CP-treatment. Histology for normal control and experimental group shows a similar pattern. The PHF has demonstrated promising therapeutic ability in cyclophosphamide-induced immunosuppression in Wistar albino rats." @default.
• W4386664037 created "2023-09-13" @default.
• W4386664037 creator A5022949325 @default.
• W4386664037 creator A5032301642 @default.
• W4386664037 creator A5032305525 @default.
• W4386664037 creator A5054351159 @default.
• W4386664037 creator A5056623774 @default.
• W4386664037 creator A5060309999 @default.
• W4386664037 creator A5092856681 @default.
• W4386664037 date "2021-01-01" @default.
• W4386664037 modified "2023-10-18" @default.
• W4386664037 title "Amelioration of Cyclophosphamide-Induced Immunosuppression after Treatment with Polyherbal Formulation Extract" @default.
• W4386664037 doi "https://doi.org/10.32527/2021/101511" @default.
• W4386664037 hasPublicationYear "2021" @default.
• W4386664037 type Work @default.
• W4386664037 citedByCount "0" @default.
• W4386664037 crossrefType "journal-article" @default.
• W4386664037 hasAuthorship W4386664037A5022949325 @default.
• W4386664037 hasAuthorship W4386664037A5032301642 @default.
• W4386664037 hasAuthorship W4386664037A5032305525 @default.
• W4386664037 hasAuthorship W4386664037A5054351159 @default.
• W4386664037 hasAuthorship W4386664037A5056623774 @default.
• W4386664037 hasAuthorship W4386664037A5060309999 @default.
• W4386664037 hasAuthorship W4386664037A5092856681 @default.
• W4386664037 hasBestOaLocation W43866640371 @default.
• W4386664037 hasConcept C126322002 @default.
• W4386664037 hasConcept C203014093 @default.
• W4386664037 hasConcept C2776694085 @default.
• W4386664037 hasConcept C2776755627 @default.
• W4386664037 hasConcept C2780252810 @default.
• W4386664037 hasConcept C512399662 @default.
• W4386664037 hasConcept C556039675 @default.
• W4386664037 hasConcept C71924100 @default.
• W4386664037 hasConceptScore W4386664037C126322002 @default.
• W4386664037 hasConceptScore W4386664037C203014093 @default.
• W4386664037 hasConceptScore W4386664037C2776694085 @default.
• W4386664037 hasConceptScore W4386664037C2776755627 @default.
• W4386664037 hasConceptScore W4386664037C2780252810 @default.
• W4386664037 hasConceptScore W4386664037C512399662 @default.
• W4386664037 hasConceptScore W4386664037C556039675 @default.
• W4386664037 hasConceptScore W4386664037C71924100 @default.
• W4386664037 hasLocation W43866640371 @default.
• W4386664037 hasOpenAccess W4386664037 @default.
• W4386664037 hasPrimaryLocation W43866640371 @default.
• W4386664037 hasRelatedWork W1978583778 @default.
• W4386664037 hasRelatedWork W2362001173 @default.
• W4386664037 hasRelatedWork W2365884061 @default.
• W4386664037 hasRelatedWork W2429914236 @default.
• W4386664037 hasRelatedWork W2441323929 @default.
• W4386664037 hasRelatedWork W3029187121 @default.
• W4386664037 hasRelatedWork W4249342726 @default.
• W4386664037 hasRelatedWork W4324286885 @default.
• W4386664037 hasRelatedWork W5047642 @default.
• W4386664037 hasRelatedWork W78229042 @default.
• W4386664037 hasVolume "11" @default.
• W4386664037 isParatext "false" @default.
• W4386664037 isRetracted "false" @default.
• W4386664037 workType "article" @default.