Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386688155> ?p ?o ?g. }
- W4386688155 abstract "Over the last decade, it has become evident that dietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and we and others have shown that dietary protein restriction (PR) extends the lifespan and healthspan of mice. Here, we examined the effect of PR on metabolic health and the development and progression of Alzheimer's disease (AD) in the 3xTg mouse model of AD. We found that PR has metabolic benefits for 3xTg mice and non-transgenic controls of both sexes, promoting leanness and glycemic control in 3xTg mice. We found that PR induces sex-specific alterations in circulating metabolites and in the brain lipidome, downregulating sphingolipid subclasses including ceramides, glucosylceramides, and sphingomyelins in 3xTg females. Consumption of a PR diet starting at 6 months of age reduced AD pathology in conjunction with reduced mTORC1 activity, increased autophagy, and had cognitive benefits for 3xTg mice. Finally, PR improved the survival of 3xTg mice. Our results demonstrate that PR slows the progression of AD at molecular and pathological levels, preserves cognition in this mouse model of AD, and suggests that PR or pharmaceutical interventions that mimic the effects of this diet may hold promise as a treatment for AD." @default.
- W4386688155 created "2023-09-13" @default.
- W4386688155 creator A5004034192 @default.
- W4386688155 creator A5005847739 @default.
- W4386688155 creator A5008793849 @default.
- W4386688155 creator A5014324998 @default.
- W4386688155 creator A5015137146 @default.
- W4386688155 creator A5017285700 @default.
- W4386688155 creator A5018615631 @default.
- W4386688155 creator A5027295664 @default.
- W4386688155 creator A5042184721 @default.
- W4386688155 creator A5049948504 @default.
- W4386688155 creator A5055444624 @default.
- W4386688155 creator A5056837747 @default.
- W4386688155 creator A5061409314 @default.
- W4386688155 creator A5065916853 @default.
- W4386688155 creator A5077817714 @default.
- W4386688155 creator A5078374361 @default.
- W4386688155 creator A5079952513 @default.
- W4386688155 creator A5085288685 @default.
- W4386688155 creator A5092857904 @default.
- W4386688155 creator A5092857905 @default.
- W4386688155 date "2023-09-12" @default.
- W4386688155 modified "2023-10-14" @default.
- W4386688155 title "Protein restriction slows the development and progression of Alzheimer's disease in mice" @default.
- W4386688155 cites W1472536133 @default.
- W4386688155 cites W1500170996 @default.
- W4386688155 cites W1523693806 @default.
- W4386688155 cites W1812391321 @default.
- W4386688155 cites W1820691791 @default.
- W4386688155 cites W1965263019 @default.
- W4386688155 cites W1966014719 @default.
- W4386688155 cites W1967464880 @default.
- W4386688155 cites W1970182368 @default.
- W4386688155 cites W1970637701 @default.
- W4386688155 cites W1973276273 @default.
- W4386688155 cites W1975959567 @default.
- W4386688155 cites W1977002082 @default.
- W4386688155 cites W1977831791 @default.
- W4386688155 cites W1978232373 @default.
- W4386688155 cites W1982313782 @default.
- W4386688155 cites W1985113736 @default.
- W4386688155 cites W1985224052 @default.
- W4386688155 cites W1986783906 @default.
- W4386688155 cites W1988261409 @default.
- W4386688155 cites W1991559589 @default.
- W4386688155 cites W1996542389 @default.
- W4386688155 cites W1999442689 @default.
- W4386688155 cites W2002499460 @default.
- W4386688155 cites W2004378479 @default.
- W4386688155 cites W2007609350 @default.
- W4386688155 cites W2019488107 @default.
- W4386688155 cites W2021933220 @default.
- W4386688155 cites W2022812411 @default.
- W4386688155 cites W2023316908 @default.
- W4386688155 cites W2024211256 @default.
- W4386688155 cites W2024871050 @default.
- W4386688155 cites W2037653131 @default.
- W4386688155 cites W2038503582 @default.
- W4386688155 cites W2042069812 @default.
- W4386688155 cites W2042438674 @default.
- W4386688155 cites W2045201133 @default.
- W4386688155 cites W2048376025 @default.
- W4386688155 cites W2049599293 @default.
- W4386688155 cites W2050502129 @default.
- W4386688155 cites W2053935454 @default.
- W4386688155 cites W2070835061 @default.
- W4386688155 cites W2070871404 @default.
- W4386688155 cites W2072543902 @default.
- W4386688155 cites W2074497389 @default.
- W4386688155 cites W2075420402 @default.
- W4386688155 cites W2077612844 @default.
- W4386688155 cites W2078380411 @default.
- W4386688155 cites W2086333867 @default.
- W4386688155 cites W2086539280 @default.
- W4386688155 cites W2095853881 @default.
- W4386688155 cites W2101531721 @default.
- W4386688155 cites W2105599318 @default.
- W4386688155 cites W2117080644 @default.
- W4386688155 cites W2121890455 @default.
- W4386688155 cites W2131116946 @default.
- W4386688155 cites W2131746860 @default.
- W4386688155 cites W2135037061 @default.
- W4386688155 cites W2138138136 @default.
- W4386688155 cites W2140627921 @default.
- W4386688155 cites W2147270926 @default.
- W4386688155 cites W2148022722 @default.
- W4386688155 cites W2148853147 @default.
- W4386688155 cites W2150665743 @default.
- W4386688155 cites W2155904162 @default.
- W4386688155 cites W2158742765 @default.
- W4386688155 cites W2161260889 @default.
- W4386688155 cites W2166953117 @default.
- W4386688155 cites W2170065584 @default.
- W4386688155 cites W2283552848 @default.
- W4386688155 cites W2291133510 @default.
- W4386688155 cites W2292595116 @default.
- W4386688155 cites W2337932523 @default.
- W4386688155 cites W2368729090 @default.
- W4386688155 cites W2466033342 @default.