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- W4386693676 abstract "Abstract Microbial synthesis of nutraceutically and pharmaceutically interesting plant polyphenols represents a more environmentally friendly alternative to chemical synthesis or plant extraction. However, most polyphenols are cytotoxic for microorganisms as they are believed to negatively affect cell integrity and transport processes. To increase the production performance of engineered cell factories, strategies have to be developed to mitigate these detrimental effects. Here, we examine the accumulation of the stilbenoid resveratrol in the cell membrane and cell wall during its production using Corynebacterium glutamicum and uncover the membrane rigidifying effect of this stilbenoid experimentally and with molecular dynamics simulations. A screen of free fatty acid supplements identifies palmitelaidic acid and linoleic acid as suitable additives to attenuate resveratrol’s cytotoxic effects resulting in a three-fold higher product titer. This cost-effective approach to counteract membrane-damaging effects of product accumulation is transferable to the microbial production of other polyphenols and may represent an engineering target for other membrane-active bioproducts." @default.
- W4386693676 created "2023-09-13" @default.
- W4386693676 creator A5003992542 @default.
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- W4386693676 creator A5085419424 @default.
- W4386693676 date "2023-09-12" @default.
- W4386693676 modified "2023-09-28" @default.
- W4386693676 title "Membrane manipulation by free fatty acids improves microbial plant polyphenol synthesis" @default.
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- W4386693676 doi "https://doi.org/10.1038/s41467-023-40947-x" @default.