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- W4386694611 abstract "The results of preclinical studies of a medicinal product for veterinary use “Vaccine associat-ed against parainfluenza-3, infectious rhinotracheitis, viral diarrhea, rotavirus and coronavirus infec-tions of cattle inactivated emulsion” are presented. The vaccine is made from concentrated parain-fluenza-3 virus antigens (strain “PTK-45/86”), infectious rhinotracheitis virus (strain “TK-A (VIEV) -V2”), viral diarrhea (strain “VK-1”), bovine rotavirus livestock (strain 2- KL-2) and cattle coro-navirus (strain RM), inactivated by formalin (0.2 % by volume), emulsified in equal proportion with oil adjuvant (15 % lanolin, 85 % PES- 3). We studied the appearance, completeness of inacti-vation, sterility, safety, antigenic activity of the vaccine, tolerance by healthy animals, double ad-ministration of the vaccine in high doses. It is established that the vaccine is sterile, harmless to ani-mals. It has high antigenic activity. Twice subcutaneous administration of a vaccine dose of 1 cm3 in rabbits induced the formation of specific antibodies in blood serum in titers of PG-3 virus 266.6±65.3 in RTGA, IRT virus – 42.6±13.0 in RVN, and VD virus – 26.6±6.53 in RVN, rotavirus – 853.3±209.0 in ELISA, coronavirus – 213.3±52.2 in RTGA. Animals tolerated the introduction of high-dose vaccines. After administering the vaccine twice in a dose 3 times higher than the prophy-lactic one, the animals did not exhibit a deviation in the physiological parameters of the body. Based on the results of the research, production tests of the vaccine will be conducted on a limited number of cattle." @default.
- W4386694611 created "2023-09-14" @default.
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- W4386694611 date "2020-12-01" @default.
- W4386694611 modified "2023-09-27" @default.
- W4386694611 title "RESULTS OF THE PRE-CLINICAL TEST OF THE ASSOCIATED VACCINE AGAINST PARAGRIP-3, INFECTIOUS RINOTRAHEITIS, VIRAL DIARRHEA, ROTA-VIRUS AND CORONAVIRUS INFECTIONS OF CATTLE" @default.
- W4386694611 doi "https://doi.org/10.31588/2413-4201-1883-244-4-183-187" @default.
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