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• W4386696750 abstract "Exopolysaccharides (EPS) from the microalgae Porphyridium cruentum, Chrysotila dentata, Pavlova sp., Diacronema sp., Glossomastix sp., Phaeodactylum tricornutum, and Synechococcus sp. were isolated and depolymerized. First, EPS were submitted to a high pressure pre-treatment step, followed by a solid acid-catalyzed hydrolysis step carried out in a batch or recycle fixed-bed reactor, using a strong acidic cation-exchange resin. Twenty-eight different EPS forms were thus obtained. After characterization of their main structural features (weight- and number-averaged molecular weight, polydispersity index, sulfate and uronic acid contents), we investigated the structure-function relationship of their pro-collagen activity. We found that native microalgae EPS were able to inhibit until 27% of human matrix metalloproteinase-1 (MMP-1) activity while the depolymerized forms were able to enhance collagen production by two different human fibroblast lines, used as cell models due to their major role in dermal collagen biosynthesis. The most active EPS forms, obtained by depolymerization in the recycle fixed-bed reactor of D. ennorea and Glossomastix sp. EPS, led to 390% increase in collagen production. Finally, principal component (PCA) and Pearson analyses indicated that MMP-1 inhibition was strongly correlated to the sulfate group content of EPS whereas collagen production by fibroblasts was mostly related to their proportion of low molecular weight polysaccharides (<10 kDa). Uronic acid content of EPS was also shown essential but only if the size of EPS was reduced in the first place. Altogether, these results gave new insights of the dermo-cosmetic potential of microalgae EPS as well as the key parameters of their activity.Six new and original EPS from microalgae were isolated.Microalgae EPS were depolymerized by high pressure/solid acid-catalyzed hydrolysis.Native EPS inhibited human matrix metalloproteinase-1.Depolymerized EPS highly stimulated collagen production by human dermal fibroblasts.Structure–function studies revealed that sulfate groups and MW of EPS were crucial." @default.
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• W4386696750 date "2023-09-12" @default.
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• W4386696750 title "Role of some structural features in EPS from microalgae stimulating collagen production by human dermal fibroblasts" @default.
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• W4386696750 doi "https://doi.org/10.1080/21655979.2023.2254027" @default.
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