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• W4386696858 abstract "A better understanding of multiple myeloma (MM) biology has led to the development of novel therapies. However, MM is still an incurable disease and new pharmacological strategies are needed. Dinaciclib, a multiple cyclin‐dependent kinase (CDK) inhibitor, which inhibits CDK1, 2, 5 and 9, displays significant antimyeloma activity as found in phase II clinical trials. In this study, we have explored the mechanism of dinaciclib‐induced death and evaluated its enhancement by different BH3 mimetics in MM cell lines as well as in plasma cells from MM patients. Our results indicate a synergistic effect of dinaciclib‐based combinations with B‐cell lymphoma 2 or B‐cell lymphoma extra‐large inhibitors, especially in MM cell lines with partial dependence on myeloid cell leukemia sequence 1 (MCL‐1). Simultaneous treatment with dinaciclib and BH3 mimetics ABT‐199 or A‐1155463 additionally showed a synergistic effect in plasma cells from MM patients, ex vivo . Altered MM cytogenetics did not affect dinaciclib response ex vivo , alone or in combined treatment, suggesting that these combinations could be a suitable therapeutic option for patients bearing cytogenetic alterations and poor prognosis. This work also opens the possibility to explore cyclin‐dependent kinase 9 inhibition as a targeted therapy in MM patients overexpressing or with high dependence on MCL‐1." @default.
• W4386696858 created "2023-09-14" @default.
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• W4386696858 date "2023-09-28" @default.
• W4386696858 modified "2023-10-16" @default.
• W4386696858 title "Dinaciclib synergizes with <scp>BH3</scp> mimetics targeting <scp>BCL</scp>‐2 and <scp>BCL‐X_L</scp> in multiple myeloma cell lines partially‐dependent on <scp>MCL</scp>‐1 and in plasma cells from patients." @default.
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• W4386696858 cites W1979989319 @default.
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• W4386696858 cites W2027728078 @default.
• W4386696858 cites W2039640090 @default.
• W4386696858 cites W2039782788 @default.
• W4386696858 cites W2041293115 @default.
• W4386696858 cites W2048217074 @default.
• W4386696858 cites W2048297293 @default.
• W4386696858 cites W2065942364 @default.
• W4386696858 cites W2066107979 @default.
• W4386696858 cites W2066694476 @default.
• W4386696858 cites W2068720118 @default.
• W4386696858 cites W2073239885 @default.
• W4386696858 cites W2074366029 @default.
• W4386696858 cites W2096439168 @default.
• W4386696858 cites W2111159843 @default.
• W4386696858 cites W2113261463 @default.
• W4386696858 cites W2115385885 @default.
• W4386696858 cites W2128526489 @default.
• W4386696858 cites W2136910701 @default.
• W4386696858 cites W2137240394 @default.
• W4386696858 cites W2140642045 @default.
• W4386696858 cites W2143238584 @default.
• W4386696858 cites W2167807253 @default.
• W4386696858 cites W2485824342 @default.
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• W4386696858 cites W2490617194 @default.
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• W4386696858 cites W2534349779 @default.
• W4386696858 cites W2761234508 @default.
• W4386696858 cites W2766623255 @default.
• W4386696858 cites W2771935866 @default.
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• W4386696858 cites W2881212502 @default.
• W4386696858 cites W2884268220 @default.
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• W4386696858 cites W2891363625 @default.
• W4386696858 cites W2892322996 @default.
• W4386696858 cites W2897811394 @default.
• W4386696858 cites W2915161729 @default.
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• W4386696858 cites W2938158852 @default.
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• W4386696858 cites W2994866770 @default.
• W4386696858 cites W2996593053 @default.
• W4386696858 cites W2998705063 @default.
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• W4386696858 cites W3010500169 @default.
• W4386696858 cites W3014119354 @default.
• W4386696858 cites W3021066042 @default.
• W4386696858 cites W3038038250 @default.
• W4386696858 cites W3040691675 @default.
• W4386696858 cites W3043399847 @default.
• W4386696858 cites W3096867320 @default.
• W4386696858 cites W3134027539 @default.
• W4386696858 cites W3136485825 @default.
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• W4386696858 cites W3166197245 @default.
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• W4386696858 cites W4312071449 @default.
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• W4386696858 cites W4318913864 @default.
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• W4386696858 doi "https://doi.org/10.1002/1878-0261.13522" @default.
• W4386696858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37704591" @default.
• W4386696858 hasPublicationYear "2023" @default.
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